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Glucose oxidase-based biosensor for glucose detection from biological fluids

Pankaj Mandpe (Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, India)
Bala Prabhakar (Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, India)
Hunny Gupta (Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, India)
Pravin Shende (Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’S NMIMS, Mumbai, India)

Sensor Review

ISSN: 0260-2288

Article publication date: 23 June 2020

Issue publication date: 21 July 2020

2575

Abstract

Purpose

The present study aims to summarize different non-invasive techniques for continuous glucose monitoring (CGM) in diabetic patients using glucose-oxidase biosensors. In diabetic patients, the self-monitoring of blood glucose (BG) levels through minimally invasive techniques provides a quick method of measuring their BG concentration, unlike conventional laboratory measurements. The drawbacks of minimally invasive techniques include physical pain, anxiety and reduced patient compliance. To overcome these limitations, researchers shifted their attention towards the development of a pain-free and non-invasive glucose monitoring system, which showed encouraging results.

Design/methodology/approach

This study reviews the development of minimally and non-invasive method for continuous glucose level monitoring in diabetic or hyperglycemic patients. Specifically, glucose monitoring using non-invasive techniques, such as spectroscopy-based methods, polarimetry, fluorescence, electromagnetic variations, transdermal extraction-based methods and using body fluids, has been discussed. The various strategies adopted for improving the overall specificity and performance of biosensors are discussed.

Findings

In conclusion, the technology of glucose oxidase-based biosensors for glucose level monitoring is becoming a strong competitor, probably because of high specificity and selectivity, low cost and increased patient compliance. Many industries currently working in this field include Google, Novartis and Microsoft, which demonstrates the significance and strong market potential of self-monitored glucose-oxidase-based biosensors in the near future.

Originality/value

This review paper summarizes comprehensive strategies for continuous glucose monitoring (CGM) in diabetic patients using non-invasive glucose-oxidase biosensors. Non-invasive techniques received significant research interest because of high sensitivity and better patient compliance, unlike invasive ones. Although the results from these innovative devices require frequent calibration against direct BG data, they might be a preferable candidate for future CGM. However, the challenges associated with designing accurate level sensors to biomonitor BG data easily and painlessly needs to be addressed.

Keywords

Acknowledgements

Declaration of interest: The authors declare that they have no potential conflict of interest.

Funding details: No funding has been received for writing the manuscript.

Disclosure statement: No financial interest or benefit has arisen from the direct applications of research.

Citation

Mandpe, P., Prabhakar, B., Gupta, H. and Shende, P. (2020), "Glucose oxidase-based biosensor for glucose detection from biological fluids", Sensor Review, Vol. 40 No. 4, pp. 497-511. https://doi.org/10.1108/SR-01-2019-0017

Publisher

:

Emerald Publishing Limited

Copyright © 2020, Emerald Publishing Limited

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