Skip to main content
SpringerLink
Log in

Determinant factors of sarcopenia in individuals with Parkinson’s disease

  • Original Article
  • Published:
Neurological Sciences Aims and scope Submit manuscript

Abstract

Objective

Evaluate the occurrence of sarcopenia and determinant factors in individuals with Parkinson’s disease (PD) in a city in northeastern Brazil.

Methods

Case series with 77 men and women (adults and older adults) with PD. The risk of sarcopenia was determined using the SARC-F and SARC-CalF screening tools. The diagnosis of sarcopenia was based on the new consensus published by the European Working Group on Sarcopenia in Older People (EWGSOP2). Sarcopenic obesity was diagnosed based on the criteria proposed by Stenholm. Disease stage and severity were determined using the Hoehn and Yahr scale and the Unified Parkinson Disease Rating Scale, respectively.

Results

The prevalence of sarcopenia was 19.5% and was associated with age, poor performance on activities of daily living and poor nutritional status. No significant association was found between the SARC-F score and the diagnosis of sarcopenia. The main factors that determined the variation in the parameters for the diagnosis of sarcopenia in the present sample were age, disease severity, body weight, and SARCF score.

Conclusion

Despite the low prevalence in the present study, sarcopenia progresses with the worsening of the nutritional status and functional capacity of individuals with PD. Further studies are needed on the factors involved in the genesis of sarcopenia. The SARC-F questionnaire is related to parameters for the diagnosis and severity of sarcopenia as well as the severity of PD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Ray Dorsey E, Elbaz A, Nichols E, Abd-Allah F, Abdelalim A, Adsuar JC et al (2018) Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet Neurol 17(11):939–953

    Article  Google Scholar 

  2. Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyère O, Cederholm T, Cooper C, Landi F, Rolland Y, Sayer AA, Schneider SM, Sieber CC, Topinkova E, Vandewoude M, Visser M, Zamboni M, Writing Group for the European Working Group on Sarcopenia in Older People 2 (EWGSOP2), and the Extended Group for EWGSOP2 (2019) Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing 48(4):601–601

    Article  Google Scholar 

  3. Drey M, Krieger B, Sieber CC, Bauer JM, Hettwer S, Bertsch T (2014) Motoneuron loss is associated with sarcopenia. J Am Med Dir Assoc [Internet]. 15(6):435–439. Available from: https://doi.org/10.1016/j.jamda.2014.02.002

  4. Vetrano DL, Pisciotta MS, Laudisio A, Lo Monaco MR, Onder G, Brandi V et al (2018) Sarcopenia in Parkinson disease: comparison of different criteria and association with disease severity. J Am Med Dir Assoc [Internet] 19(6):523–527. Available from: https://doi.org/10.1016/j.jamda.2017.12.005

    Article  Google Scholar 

  5. Barichella M, Pinelli G, Iorio L, Cassani E, Valentino A, Pusani C, Ferri V, Bolliri C, Pasqua M, Pezzoli G, Frazzitta G, Cereda E (2016) Sarcopenia and dynapenia in patients with parkinsonism. J Am Med Dir Assoc [Internet]. 17(7):640–646. Available from: https://doi.org/10.1016/j.jamda.2016.03.016

  6. Yazar T, Yazar HO, Zayimoğlu E, Çankaya S (2018) Incidence of sarcopenia and dynapenia according to stage in patients with idiopathic Parkinson’s disease. Neurol Sci 39(8):1415–1421

    Article  Google Scholar 

  7. Ozer FF, Akın S, Gultekin M, Zararsız GE (2019) Sarcopenia, dynapenia, and body composition in Parkinson’s disease: are they good predictors of disability?: a case–control study. Neurol Sci

  8. Postuma RB, Berg D, Stern M, Poewe W, Olanow CW, Oertel W, Obeso J, Marek K, Litvan I, Lang AE, Halliday G, Goetz CG, Gasser T, Dubois B, Chan P, Bloem BR, Adler CH, Deuschl G (2015) MDS clinical diagnostic criteria for Parkinson’s disease. Mov Disord 30(12):1591–1601

    Article  Google Scholar 

  9. Barbosa-Silva TG, Menezes AMB, Bielemann RM, Malmstrom TK, Gonzalez MC (2016) Enhancing SARC-F: Improving sarcopenia screening in the clinical practice. J Am Med Dir Assoc [Internet] 17(12):1136–1141. Available from: https://doi.org/10.1016/j.jamda.2016.08.004

  10. Stenholm S, Harris T, Rantenen T, Visser M, Kritchevsky SB, Ferrucci L (2008) Sarcopenic obesity-definition,etiology and consequences. Curr Opin Clin Nutr Metab Care 11(6):693–700

    Article  Google Scholar 

  11. Roberts HC, Denison HJ, Martin HJ, Patel HP, Syddall H, Cooper C, Sayer AA (2011) A review of the measurement of grip strength in clinical and epidemiological studies: towards a standardised approach. Age Ageing 40(4):423–429

    Article  Google Scholar 

  12. Sergi G, De Rui M, Veronese N, Bolzetta F, Berton L, Carraro S et al (2015) Assessing appendicular skeletal muscle mass with bioelectrical impedance analysis in free-living Caucasian older adults. Clin Nutr [Internet] 34(4):667–673. Available from: https://doi.org/10.1016/j.clnu.2014.07.010

  13. WHO. WHO_TRS_854.pdf [Internet]. 1995. p. 1–463. Available from: http://www.who.int/childgrowth/publications/physical_status/en/

  14. Organization WH. World Health Organization Obesity. Preventing and managing the global epidemic : report of a WHO Consultation. 1998. p. 275

  15. Barbosa-Silva TG, Bielemann RM, Gonzalez MC, Menezes AMB (2015) Prevalence of sarcopenia among community-dwelling elderly of a medium-sized South American city: results of the COMO VAI? Study J Cachexia Sarcopenia Muscle 7(2):136–143

    Article  Google Scholar 

  16. Kyle UG , Genton L , Karsegard L , Slosman DO , Pichard C (2001) Single Prediction Equation for Bioelectrical Impedance Analysis in Adults Aged 20– 94 Years. Nutrition 17:248–253. https://doi.org/10.1016/s0899-9007(00)00553-0

  17. Hoehn MM, Yahr MD (1967) Parkinsonism : onset, progression, and mortality parkinsonism: onset, progression, and mortality. Neurol Int 17(5):427–442 Available from: http://www.neurology.org/content/17/5/427.citation

    CAS  Google Scholar 

  18. Martínez-Martín P, Gil-Nagel A, Gracia LM, Gómez JB, Martínez-Sarriés J, Bermejo F (1994) Unified Parkinson’s disease rating scale characteristics and structure. Mov Disord 9(1):76–83

    Article  Google Scholar 

  19. Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinková E, Vandewoude M, Zamboni M, European Working Group on Sarcopenia in Older People (2010) Sarcopenia: European consensus on definition and diagnosis. Age Ageing 39(4):412–423

    Article  Google Scholar 

  20. Maetzler W, Drey M, Jacobs AH (2015) Sarkopenie und Frailty in der Neurologie. Nervenarzt. 86(4):420–430

    Article  CAS  Google Scholar 

  21. Drey M, Hasmann SE, Krenovsky JP, Hobert MA, Straub S, Elshehabi M et al (2017) Associations between early markers of Parkinson’s disease and sarcopenia. Front Aging Neurosci 9(MAR):1–5

    Google Scholar 

  22. Küsbeci ÖY (2019) Sarcopenia in Parkinson’s disease patients. 36(June 2015):28–32

  23. Alexandre TDS, Duarte YADO, Santos JLF, Wong R, Lebrão ML (2014) Prevalence and associated factors of sarcopenia among elderly in Brazil: findings from the sabe study. J Nutr Heal Aging. 18(3):284–290

    Article  Google Scholar 

  24. Delmonico MJ, Harris TB, Visser M, Park SW, Conroy MB, Velasquez-Mieyer P, Boudreau R, Manini TM, Nevitt M, Newman AB, Goodpaster BH, Health, Aging, and Body (2009) Longitudinal study of muscle strength, quality, and adipose tissue infiltration. Am J Clin Nutr 90(6):1579–1585

    Article  CAS  Google Scholar 

  25. Clark BC, Manini T (2012) What is dynapenia? Nutrition. 28(5):495–503

    Article  Google Scholar 

  26. Kim M, Won CW (2019) Prevalence of sarcopenia in community-dwelling older adults using the definition of the European working group on sarcopenia in older people 2: findings from the Korean frailty and aging cohort study. Age Ageing 2:1–7

    Google Scholar 

  27. Sayer AA, Syddall H, Martin H, Patel H, Baylis D, Cooper C (2008) The developmental origins of sarcopenia. J Nutr Heal Aging 12(7):427–432

    Article  CAS  Google Scholar 

  28. Takata Y, Ansai T, Soh I, Awano S, Yoshitake Y, Kimura Y (2012) Physical fitness and 6.5-year mortality in an 85-year-old community-dwelling population. Arch Gerontol Geriatr [Internet] 54(1):28–33. Available from: https://doi.org/10.1016/j.archger.2011.04.014

  29. Lima LO, Scianni A, Rodrigues-de-Paula F (2013) Progressive resistance exercise improves strength and physical performance in people with mild to moderate Parkinson’s disease: a systematic review. J Physiother [Internet] 59(1):7–13. Available from: https://doi.org/10.1016/S1836-9553(13)70141-3

  30. Roberts HC, Syddall HE, Butchart JW, Stack EL, Cooper C, Sayer AA (2015) The association of grip strength with severity and duration of Parkinson’s: a cross-sectional study. Neurorehabil Neural Repair 29(9):889–896

    Article  Google Scholar 

  31. Hubble RP, Silburn PA, Naughton GA, Cole MH (2016) Assessing stability in mild and moderate Parkinson’s disease: can clinical measures provide insight? Gait Posture [Internet] 49:7–13. Available from: https://doi.org/10.1016/j.gaitpost.2016.06.002

  32. Tan AH, Hew YC, Lim SY, Ramli NM, Kamaruzzaman SB, Tan MP et al (2018) Altered body composition, sarcopenia, frailty, and their clinico-biological correlates, in Parkinson’s disease. Park Relat Disord [Internet] 56(March):58–64. Available from. https://doi.org/10.1016/j.parkreldis.2018.06.020

    Article  Google Scholar 

  33. Petroni ML, Albani G, Bicchiega V, Baudo S, Vinci C, Montesano A et al (2003) Body composition in advanced-stage Parkinson’s disease. Acta Diabetol 40(SUPPL. 1):187–190

    Article  Google Scholar 

  34. Wang CK, Chen HL, Lu CH et al (2019) Altered body composition of psoas and thigh muscles in relation to frailty and severity of Parkinson’s disease. Int J Environ Res Public Health 16(19):3667. https://doi.org/10.3390/ijerph16193667

  35. Rolland Y, Dupuy C, Abellan Van Kan G, Cesari M, Vellas B, Faruch M et al (2017) Sarcopenia Screened by the SARC-F questionnaire and physical performances of elderly women: a cross-sectional study. J Am Med Dir Assoc [Internet] 18(10):848–852. Available from: https://doi.org/10.1016/j.jamda.2017.05.010

  36. Peball M, Mahlknecht P, Werkmann M, Marini K, Murr F, Herzmann H, Stockner H, de Marzi R, Heim B, Djamshidian A, Willeit P, Willeit J, Kiechl S, Valent D, Krismer F, Wenning GK, Nocker M, Mair K, Poewe W, Seppi K (2018) Prevalence and associated factors of sarcopenia and frailty in Parkinson’s disease: a cross-sectional study. Gerontology. 65(3):216–228

    Article  Google Scholar 

  37. Allen NE, Canning CG, Sherrington C, Fung VSC (2009) Bradykinesia, muscle weakness and reduced muscle power in Parkinson’s disease. Mov Disord 24(9):1344–1351

    Article  Google Scholar 

  38. Sirtori CR, Bolme PAD (1972) Metabolic responses to acute and chronic L-dopa administration in patients with parkinsonism. N Engl J Med 287(15):729–733

    Article  CAS  Google Scholar 

  39. Kera T, Kawai H, Hirano H, Kojima M, Watanabe Y, Motokawa K et al (2020) Limitations of SARC-F in the diagnosis of sarcopenia in community-dwelling older adults. Arch Gerontol Geriatr [Internet] 87(July):103959. Available from: https://doi.org/10.1016/j.archger.2019.103959

Download references

Author information

Author notes

  1. Marcella Campos Lima da Luz

    Present address: , Jaboatão dos Guararapes, Brazil

Authors and Affiliations

  1. Department of Nutrition, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Marcella Campos Lima da Luz, Gleyce Kelly Araújo Bezerra, Maria da Conceição Chaves de Lemos & Poliana Coelho Cabral

  2. Hospital das Clínicas, Federal University of Pernambuco, Recife, Pernambuco, Brazil

    Marcella Campos Lima da Luz & Amdore Guescel C. Asano

Authors
  1. Marcella Campos Lima da Luz
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Gleyce Kelly Araújo Bezerra
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Amdore Guescel C. Asano
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Maria da Conceição Chaves de Lemos
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Poliana Coelho Cabral
    View author publications

    You can also search for this author in PubMed Google Scholar

Ethics declarations

Conflict of interest

There is no conflict of interest in this article.

Ethical approval

This work was approved by the ethics and research committee of Hospital of Clinicas in Pernambuco with the approval number: 98691118.2.0000.8807.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

da Luz, M.C.L., Bezerra, G.K., Asano, A.G.C. et al. Determinant factors of sarcopenia in individuals with Parkinson’s disease. Neurol Sci 42, 979–985 (2021). https://doi.org/10.1007/s10072-020-04601-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10072-020-04601-4

Keywords

Search

Navigation