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Optimization of Microparticle Coating Parameters with Cell Wall of Saccharomyces cerevisiae by Fractional Factorial Design

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Abstract

Abstract

The design of multiparticulate systems is a high-impact technological strategy in the formulation of immunomodulators for oral administration, fluid bed coating being a technique used due to its versatility and relatively low cost.

Purpose

The objective of this work was to cover a solid support (Suglets® of Colorcon®) with an extract of cell wall of Saccharomyces cerevisiae through a fluidized bed system to determine the influence of operation and formulation conditions in the quality and performance of the product. This was carried out through a fractional factorial design.

Methods

Evaluating the performance of the coating process, the weight gain of the spheres, the amount of process stops, and the morphological and qualitative analysis of the microparticles coated.

Results and conclusion:

Although more promising operating conditions were observed, this work verifies that there is not a single combination of levels of each factor that provides good results with respect to the performance of coating process.

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Acknowledgments

The authors would like to thank sincerely Colorcon® INC. for supplying the free Suglets® samples and to Lambabue-Inmunowall for providing free sample of cell wall extract of Saccharomyces cerevisiae (B). We also express our gratitude to the company Caleva for its technical support throughout the work.

Funding

This work is funded by the Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) and Universidad Nacional de Villa María.

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Authors and Affiliations

  1. Instituto Académico Pedagógico de Ciencias Básicas y Aplicadas, UNVM, 5900, Villa María, Córdoba, Argentina

    SG Brignone

  2. Departamento de Ciencias Farmacéuticas - Facultad de Ciencias Químicas, Universidad Nacional de Córdoba (FCQ-UNC), 5000, Córdoba, Argentina

    SG Brignone

  3. Centro de Investigaciones y Transferencia Villa Maria (CIT VM), 5900, Villa María, Córdoba, Argentina

    S Ravetti

  4. Instituto Académico Pedagógico de Ciencias Humanas, UNVM, 5900, Villa María, Córdoba, Argentina

    S Ravetti

  5. Departamento de Bioquímica Clínica, FCQ-UNC, 5000, Córdoba, Argentina

    BA Maletto

  6. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Centro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), 5000, Córdoba, Argentina

    BA Maletto

  7. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica (UNITEFA), CONICET and Departamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba. Ciudad Universitaria , 5000, Córdoba, Argentina

    SD Palma

Authors
  1. SG Brignone
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  2. S Ravetti
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  3. BA Maletto
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Corresponding author

Correspondence to SG Brignone.

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Brignone, S., Ravetti, S., Maletto, B. et al. Optimization of Microparticle Coating Parameters with Cell Wall of Saccharomyces cerevisiae by Fractional Factorial Design. J Pharm Innov 16, 603–619 (2021). https://doi.org/10.1007/s12247-020-09473-x

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  • DOI: https://doi.org/10.1007/s12247-020-09473-x

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