Abstract
Cadmium telluride (CdTe) and silver-doped CdTe (CdTe/Ag) nanocrystals have been used to study the antibacterial activity against gram-positive bacteria (Streptococcus pneumoniae and Staphylococcus aureus) and gram-negative bacteria (Klebsiella pneumoniae and Escherichia coli) by disc diffusion method. Here, CdTe and CdTe/Ag nanocrystals have been prepared by chemical method and characterized by transmission electron microscope (TEM) and X-ray diffraction (XRD). TEM images show that both the nanocrystals are spherical in shape with an average diameter of 6 nm and 5 nm respectively, whereas XRD pattern indicates that these nanocrystals are cubic in structure. Further, nuclear magnetic resonance study as well as FTIR spectral study confirm that prepared nanocrystals are well capped by 3-marcaptopropionic acid. For antibacterial test, different concentrations from 1 to 10 μg ml−1 of CdTe and CdTe/Ag nanocrystals are placed in the agar broth against all the gram-positive and gram-negative bacterial strains. Here, Ampicillin and water have been used as a standard reference and a control respectively. It is found that both the nanocrystals are effective against all the bacterial strains and the zone of inhibition (ZOI) is measured after 24 h of incubation. But, CdTe/Ag nanocrystals show much more ZOI than CdTe nanocrystals. Among the gram-positive bacteria, these nanocrystals are more effective against S. pneumonia (ZOI-9 mm for 1 µg ml−1), compared to S. aureus (ZOI-8 mm for 1 µg ml−1). Whereas, among the gram-negative bacteria, activity is more against the E. Coli (ZOI-8 mm for 1 µg ml−1) than that in K. pneumonia (ZOI-6.5 mm for 1 µg ml−1).
Similar content being viewed by others
References
Arivarasan A, Bharathi S, Vijayaraj V, Sasikala G, Jayavel R (2018) Evaluation of reaction parameters dependent optical properties and its photovoltaics performances of CdTe QDs. J Inorg Organomet Polym Mater 28:1263–1275. https://doi.org/10.1007/s10904-018-0803-1
Ayala-Núñez NV, Villegas HHL, Turrent LdCI, Padilla CR (2009) Silver nanoparticles toxicity and bactericidal effect against methicillin-resistant staphylococcus aureus: nanoscale does matter. NanoBiotechnology 5(1–4):2–9. https://doi.org/10.1007/s12030-009-9029-1
Bang JH, Kamat PV (2009) Quantum dot sensitized solar Cells. A tale of two semiconductor nanocrystals: CdSe and CdTe. ACS Nano 3:1467–1476. https://doi.org/10.1021/nn900324q
Bao H, Wang E, Dong S (2006) One-pot synthesis of CdTe nanocrystals and shape control of luminescent CdTe–cystine nanocomposites. Small 2(4):476–480. https://doi.org/10.1002/smll.200500346
Belskaya OB et al (2016) Transformation pathways of 2,4,6-trinitrobenzoic acid in the aqueous-phase hydrogenation over Pd/C catalyst. J Mol Catal A Chem 420:190–199. https://doi.org/10.1016/j.molcata.2016.04.014
Blount ZD (2015) The natural history of model organisms: the unexhausted potential of E coli. eLife 4:05826. https://doi.org/10.7554/eLife.05826.001
Chatterjee AK, Chakraborty R, Basu T (2014) Mechanism of antibacterial activity of copper nanoparticles. Nanotechnology 25(13):135101. https://doi.org/10.1088/0957-4484/25/13/135101
Chiavolini D, Pozzi G, Ricci S (2008) Animal models of streptococcus pneumoniae disease. Clin Microbiol Rev 21(4):666–685. https://doi.org/10.1128/CMR.00012-08
Clifton LA et al (2015) Effect of divalent cation removal on the structure of gram-negative bacterial outer membrane models. Langmuir 31(1):404–412. https://doi.org/10.1021/la504407v
Coates ARM, Hu Y (2007) Novel approaches to developing new antibiotics for bacterial infections. Br J Pharmacol 152(8):1147–1154. https://doi.org/10.1038/sj.bjp.0707432
Das R, Sarkar S, Saha M, Dey PC, Nath SS (2015) Two peak luminescence from linoleic acid protected gold nanoparticles. J Lumin 168:325–329. https://doi.org/10.1016/j.jlumin.2015.08.047
DeAlba-Montero I et al (2017) Antimicrobial properties of copper nanoparticles and amino acid chelated copper nanoparticles produced by using a soya extract. Bioinorgan Chem Appl. https://doi.org/10.1155/2017/1064918
Dey PC, Das R (2017) Photoluminescence quenching in ligand free CdS nanocrystals due to silver doping along with two high energy surface states emission. J Lumin 183:368–376. https://doi.org/10.1016/j.jlumin.2016.11.071
Dey PC, Das R (2018) Effect of silver doping on the elastic properties of CdS nanoparticles. Indian J Phys 92(9):1099–1108. https://doi.org/10.1007/s12648-018-1214-4
Díez-Pascual AM (2018) Antibacterial activity of nanomaterials. Nanomaterials 8:359. https://doi.org/10.3390/nano8060359
Ding S et al (2015) Synthesis and enhanced fluorescence of Ag doped CdTe semiconductor quantum dots. Nanoscale 7:1970. https://doi.org/10.1039/C4NR05731G
Dizaji HR, Parand P (2014) Tuning the luminescence of CdS quantum dots by a simple method. J Nanostruct 4(2):193–197. https://doi.org/10.7508/jns.2014.02.009
Dowlatababdi FH, Amiri G, Sichani MM (2017) Investigation of the antimicrobial effect of silver doped zinc oxide nanoparticles. Nanomed J 4(1):50–54. https://doi.org/10.22038/nmj.2017.8053
Fultz B, Howe J (2013) Transmission electron microscopy and diffractometry of materials, graduate texts in physics. Springer, Berlin. https://doi.org/10.1007/978-3-642-29761-8_1
Geraldo DA, Arancibia-Miranda N, Villagra N, Mora GC, Arratia-Perez R (2012) Synthesis of CdTe QDs/single-walled aluminosilicate nanotubes hybrid compound and their antimicrobial activity on bacteria. J Nanopart Res 14:1286. https://doi.org/10.1007/s11051-012-1286-6
Guo B et al (2015) The antibacterial activity of Ta-doped ZnO nanoparticles. Nanoscale Res Lett 10:336. https://doi.org/10.1186/s11671-015-1047-4
Hajipour MJ et al (2012) Antibacterial properties of nanoparticles. Trends Biotechnol 30(10):499–511. https://doi.org/10.1016/j.tibtech.2012.06.004
Jang J et al (2017) Environmental Escherichia coli: ecology and public health implications-a review. J Appl Microbiol 123:570–581. https://doi.org/10.1111/jam.13468
Klasen HJ (2000) Historical review of the use of silver in the treatment of burns. I. Early uses. Burns 26:117–130. https://doi.org/10.1016/S0305-4179(99)00116-3
Kumar H, Srivastava R, Dutta PK (2013) Highly luminescent chitosan-l-cysteine functionalized CdTe quantum dots film: synthesis and characterization. Carbohyd Polym 97:327. https://doi.org/10.1016/j.carbpol.2013.04.056
Lappi SE, Smith B, Franzen S (2004) Infrared spectra of H216O, H218O and D2O in the liquid phase by single-pass attenuated total internal reflection spectroscopy. Spectrochim Acta A 60:2611
Li B, Webster TJ (2018) Bacteria antibiotic resistance: new challenges and opportunities for implant-associated orthopaedic infections. J Orthop Res 36(1):22–32. https://doi.org/10.1002/jor.23656
Lin L et al (2013) Aqueous synthesis of Ag+ doped CdS quantum dots and its application in H2O2 sensing. Anal Methods 5:457–464. https://doi.org/10.1039/C2AY26063H
Luo Z et al (2011) Cooperative antimicrobial activity of CdTe quantum dots with rocephin and fluorescence monitoring for Escherichia coli. J Colloid Interface Sci 362:100–106. https://doi.org/10.1016/j.jcis.2011.06.039
Majid A, Tanveer M, Rana UA, Khan SU, Kousar S (2016) Facile synthesis of Mn-doped CdTe nanoparticles: structural and magnetic properties. J Supercond Nov Magn 29:2615. https://doi.org/10.1007/s10948-016-3570-7
Malarkodi C et al (2014) Biosynthesis and antimicrobial activity of semiconductor nanoparticles against oral pathogens. Bioinorgan Chem Appl 45:50. https://doi.org/10.1155/2014/347167
Melinte V, Buruiana T, Morarua ID, Buruiana EC (2011) Silver-polymer composite materials with antibacterial properties. Dig J Nanomater Biostruct 6(1):213–223
Meruvu H, Vangalapati M, Chippada SC, Bammidi SR (2011) Synthesis and characterization of zinc oxide nanoparticles and its antimicrobial activity against bacillus subtilis and Escherichia Coli, Rasayan. J Chem 4:217–222
Mironyuk I, Tatarchuk T, Naushad M, Vasylyeva H, Mykytyn I (2019) Highly efficient adsorption of strontium ions by carbonated mesoporous TiO2. J Mol Liq 285:742. https://doi.org/10.1016/j.molliq.2019.04.111
Naushad M, Sharma G, Alothman ZA (2019) Photodegradation of toxic dye using Gum Arabic-crosslinked-poly(acrylamide)/Ni(OH)2/FeOOH nanocomposites hydrogel. J Clean Prod 241:118263. https://doi.org/10.1016/j.jclepro.2019.118263
Nikaido H (2009) Multidrug resistance in bacteria. Annu Rev Biochem 78:119–146. https://doi.org/10.1146/annurev.biochem.78.082907.145923
Othman SH (2014) Antimicrobial activity of TiO2 nanoparticle-coated film for potential food packaging applications. Int J Photoenergy. https://doi.org/10.1155/2014/945930
Palza H, Quijada R, Delgado K (2015) Antimicrobial polymer composites with copper microand nanoparticles: effect of particle size and polymer matrix. J Bioactive Comp Polym 30(4):1–15. https://doi.org/10.1177/0883911515578870
Park S, Chibli H, Wong J, Nadeau JL (2011) Antimicrobial activity and cellular toxicity of nanoparticle–polymyxin B conjugates. Nanotechnology 22:185101–185111. https://doi.org/10.1088/0957-4484/22/18/185101
Pazhanivel T, Nataraj D, Devarajan VP, Mageshwari V, Senthil K, Soundarajan D (2013) Improved sensing performance from methionine capped CdTe and CdTe/ZnS quantum dots for the detection of trace amounts of explosive chemicals in liquid media. Anal Methods 5:910. https://doi.org/10.1039/C2AY26199E
Petchiappan A, Chatterji D (2017) Antibiotic resistance: current perspectives. ACS Omega 2:7400–7409. https://doi.org/10.1021/acsomega.7b01368
Podschun R, Ullmann U (1998) Klebsiella spp. as nosocomial pathogens: epidemiology, taxonomy, typing methods, and pathogenicity factors. Clin Microbiol Rev 11:589–603. https://doi.org/10.1128/CMR.11.4.589
Raghupathi KR, Koodali RT, Manna AC (2011) Size-dependent bacterial growth inhibition and mechanism of antibacterial activity of zinc oxide nanoparticles. Langmuir 27(7):4020–4028. https://doi.org/10.1021/la104825u
Raj KP et al (2018) Influence of Mg doping on ZnO nanoparticles for enhanced photocatalytic evaluation and antibacterial analysis. Nanoscale Res Lett 13:229. https://doi.org/10.1186/s11671-018-2643-x
Reinhart CC, Johansson E (2015) Colloidally prepared 3-mercaptopropionic acid capped lead sulfide quantum dots. Chem Mater 27:7313–7320. https://doi.org/10.1021/acs.chemmater.5b02786
Reinhart CC, Johansson E (2017) Colloidal 3-mercaptopropionic acid capped lead sulfide quantum dots in a low boiling point solvent. J Am Chem Soc 139:5827–5835. https://doi.org/10.1021/jacs.7b00158
Salomoni R, Léo P, Montemor AF, Rinaldi BG, Rodrigues MFA (2017) Antibacterial effect of silver nanoparticles in Pseudomonas aeruginosa. Nanotechnol Sci Appl. 10:115–121. https://doi.org/10.2147/NSA.S133415
Sarwar A, Katas H, Samsudin SN, Zin NM (2015) Regioselective sequential modification of chitosan via azide-alkyne click reaction: synthesis, characterization, and antimicrobial activity of chitosan derivatives and nanoparticles. PLoS ONE 10(4):e0123084. https://doi.org/10.1371/journal.pone.0123084
Schneider R (2009) The exposure of bacteria to CdTe-core quantum dots: the importance of surface chemistry on cytotoxicity. Nanotechnology 20:225101–225111. https://doi.org/10.1088/0957-4484/20/22/225101
Sharma G, Pathania D, Naushad M, Kothiyal NC (2014) Fabrication, characterization and antimicrobial activity of polyaniline Th(IV) tungstomolybdophosphate nanocomposite material: Efficient removal of toxic metal ions from water. Chem Eng J 251:413. https://doi.org/10.1016/j.cej.2014.04.074
Sharma G et al (2019) Novel development of nanoparticles to bimetallic nanoparticles and their composites: a review. J King Saud Univ Sci 31:257. https://doi.org/10.1016/j.jksus.2017.06.012
Shekh MI, Patel DM, Patel KP et al (2016) Electrospun nanofibers of poly(NPEMA-co-CMPMA): used as heavy metal ion remover and water sanitizer. Fibers Polym 17:358
Shekh MI, Patel KP, Patel RM (2018) Electrospun ZnO nanoparticles doped core-sheath nanofibers: characterization and antimicrobial properties. J Polym Environ 26:4376. https://doi.org/10.1007/s10924-018-1310-8
Shivashankarappa A, Sanjay KR (2015) Study on biological synthesis of cadmium sulfide nanoparticles by bacillus licheniformis and its antimicrobial properties against food borne pathogens. Nanosci Nanotechnol Res 3(1):6–15
Siddiqi KSA, Rao RAK (2018) A review on biosynthesis of silver nanoparticles and their biocidal properties. J Nanobiotechnol 16(14):1–28. https://doi.org/10.1186/s12951-018-0334-5
Singh S et al (2017) Easy, one-step synthesis of CdTe quantum dots via microwave irradiation for fingerprinting application. Mater Res Bull 90:260–265. https://doi.org/10.1016/j.materresbull.2017.03.003
Sundaria A et al (2015) Synthesis of star shaped Cu doped CdS nanoparticles and their antibacterial effect. Macromol Symp 357:223–228. https://doi.org/10.1002/masy.201500036
Tacconelli E et al (2018) Discovery, research, and development of new antibiotics: the WHO priority list of antibiotic-resistant bacteria and tuberculosis. Lancet Inf Dis 18(3):318–327. https://doi.org/10.1016/S1473-3099(17)30753-3
Tang S, Zheng J (2018) Antibacterial activity of silver nanoparticles: structural effects. Adv Healthcare Mater 7(13):1701503. https://doi.org/10.1002/adhm.201701503
Tatarchuk T et al (2019) Adsorptive removal of toxic methylene blue and acid orange 7 dyes from aqueous medium using cobalt-zinc ferrite nano adsorbents. Desalin Water Treat 150:374. https://doi.org/10.5004/dwt.2019.23751
Thakur M, Sharma G, Ahamad T, Ghfar AA, Pathania D, Naushad M (2017) Efficient photocatalytic degradation of toxic dyes from aqueous environment using gelatin-Zr(IV) phosphate nanocomposite and its antimicrobial activity. Colloids Surf B 157:456. https://doi.org/10.1016/j.colsurfb.2017.06.018
Ventola CL (2015) The antibiotic resistance crisis part 1: causes and threats. Pharm Ther 40(4):277–283
Vlaskin VA, Janssen N, Rijssel J, Beaulac R, Gamelin DR (2010) Tunable dual emission in doped semiconductor nanocrystals. Nano Lett 10:3670–3674. https://doi.org/10.1021/nl102135k
Wang C et al (2009) CdS-Ag nanocomposite arrays: enhanced electro-chemiluminescence but quenched photoluminescence. J Mater Chem 19:3841–3846. https://doi.org/10.1039/B821213A
Wang K, Su P, Li H et al (2019) Synthesis, characterization and antimicrobial activity of hybrid-structured Ag@CeO2 nanoparticles. Chem Pap 73:1279. https://doi.org/10.1007/s11696-019-00681-5
Willey JM, Sherwood LM, Woolverton CJ (2008) Microbiology, 7th edn. McGraw-Hill Publisher, New York
Xie Y, He Y, Irwin PL, Jin T, Shi X (2011) Antibacterial activity and mechanism of action of zinc oxide nanoparticles against campylobacter jejuni. Appl Environ Microbiol 77(7):2325–2331
Young AG, Green DP, McQuillan AJ (2006) Infrared spectroscopic studies of monothiol ligand adsorption on CdS nanocrystal films in aqueous solutions. Langmuir 22:11106. https://doi.org/10.1021/la061999s
Zare M et al (2018) Surfactant assisted solvothermal synthesis of ZnO nanoparticles and study of their antimicrobial and antioxidant properties. J Mater Sci Technol 34(6):1035–1043
Zhang F, He F, He X, Li W, Zhang Y (2014) Aqueous synthesis of highly luminescent surface Mn2+-doped CdTe quantum dots as a potential multimodal agent. Luminescence 29:1059–1065
Acknowledgement
All the authors are grateful to the SAIF (NEHU), Shillong for TEM micrograph and also Mr. Krishna Deb, Department of Physics, NIT Agartala, for the analysis of X-ray diffraction. The authors are also thankful to FIST-DST Program Govt. of India (Ref. NO. SR/FST/PSI-191/2014, Dated 21.11.2014) for providing financial grant to the Department. Additionally, authors are thankful to UGC-SAP, Govt. of India (Ref. No F.530/23/DRS-I/2018 (SAP-I) dated 24/04/2018) for the financial grant to the Department.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of Interest
All the authors declare there is no conflict of interest.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Dey, P.C., Nath, P., Maiti, D. et al. Antibacterial activity of MPA-capped CdTe and Ag-doped CdTe nanocrystals: Showing different activity against gram-positive and gram-negative bacteria. Chem. Pap. 74, 3409–3421 (2020). https://doi.org/10.1007/s11696-020-01170-w
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11696-020-01170-w