Abstract
Psoriasis-2 (PSORS2) is caused by the heterozygous mutation of the caspase recruitment domain 14 (CARD14) gene on chromosome 17q25. To evaluate the contribution of CARD14 variants in psoriasis of the Chinese Han population, we performed deep sequencing of the CARD14 gene in 372 Chinese Han patients with psoriasis. The exonic nucleotide variants were confirmed by Sanger sequencing in the affected individuals and 1114 controls. In 27 patients with psoriasis, we identified 15 variations, including three novel variants: c.381C>G (p.Cys127Trp), c.712A>G (p.Met238Val) and c.2260_2261delinsGG (p.Gln754Gly). These findings could enrich and update the Human Gene Mutation Database of CARD14 variants for psoriasis.
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Acknowledgments
We thank all patients who participated in this study. Special thanks should be given to Ms. Lianxiang Zhang for her support and assistance. This study was sponsored by the grants from National Natural Science Foundation of China (no. 81673073).
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Huang, Y., Zhang, C., Tao, L. et al. Updating and identifying three novel variants of the CARD14 gene in Chinese Han patients with psoriasis. J Genet 99, 61 (2020). https://doi.org/10.1007/s12041-020-01219-5
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DOI: https://doi.org/10.1007/s12041-020-01219-5