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Hormonal and Cytokine Blood Profile of Dairy Cows in the Early Gestation Period

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Abstract—The results of the studies on the evaluation of changes in the hormonal and cytokine status of black-and-white Holstein cows (n = 25) during the period of embryogenesis at the physiological formation of pregnancy, intrauterine growth retardation, and embryonic demise are presented. The levels of progesterone, cortisol, interleukin IL-2, tumor necrosis factor TNFα, interferon-γ, and interferon-tau were determined in the dynamics of gestation in blood serum. It was found that, in case of embryogenetic disorder, the blood concentration of progesterone was lower than in animals with physiological course of pregnancy by 14.0–30.1%, cortisol by 17.8–35.2%, and interferon-tau by 22.0–37.7%, while IL-2 indexes were excessed by 46.5–31.0%, TNFα by 11.7–36.2%, and interferon-γ by 44.0–78.0%. The disturbance of the hormonal-cytokine balance in the organism of inseminated and fertilized animals is a universal pathogenesis of early embryopathies and is a key point at the clinical manifestation of these pathologies.

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Authors and Affiliations

  1. All-Russia Research Veterinary Institute of Pathology, Pharmacology, and Therapy (Federal State Budgetary Scientific Institution), 394087, Voronezh, Russia

    A. G. Nezhdanov, S. V. Shabunin, V. I. Mikhalev & N. V. Pasko

  2. Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academу of Sciences, 119991, Moscow, Russia

    V. A. Safonov

Authors
  1. A. G. Nezhdanov
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  2. S. V. Shabunin
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  3. V. I. Mikhalev
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  4. N. V. Pasko
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  5. V. A. Safonov
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Corresponding authors

Correspondence to V. I. Mikhalev or V. A. Safonov.

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Conflict of interests. The authors declare that they have no conflict of interest.

Statement on the welfare of animals. All applicable international, national, and/or institutional guidelines for the care and use of animals were followed.

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Translated by I. Shipounova

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Nezhdanov, A.G., Shabunin, S.V., Mikhalev, V.I. et al. Hormonal and Cytokine Blood Profile of Dairy Cows in the Early Gestation Period. Russ. Agricult. Sci. 46, 310–313 (2020). https://doi.org/10.3103/S1068367420030131

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  • DOI: https://doi.org/10.3103/S1068367420030131

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