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Synthesis of quinozilinium fluoroborate salts from harmine

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Abstract

Molecules possessing harmine moiety are reported to exhibit marked fungicidal and bactericidal activities. In this study, various quinozilinium tetrafluoroborate salts were synthesized using acylic and cyclic oxoketene dithioacetals followed by cycloaromatization from Harmine. All of these synthesized compounds were characterized by 1H NMR, 13C NMR, Mass and CHN analysis. This methodology would find wide usage in the preparation of indolo quinozilinium -based library of small molecules useful for medicinal chemistry and in drug discovery.

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Acknowledgements

The authors sincerely thank International Medical University, Malaysia for the encouragement and support.

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Authors and Affiliations

  1. Department of Chemistry, ANR College, Gudivada, Andhra Pradesh, 521301, India

    Sivanath Musunuri

  2. Department of Chemistry, University College of Engineering (Autonomous), Jawaharlal Nehru Technological University, Kakinada, Andhra Pradesh, 533003, India

    Reddymasu Sreenivasulu

  3. Pharmaceutical Chemistry Department, School of Pharmacy, International Medical University, 126, Jalan Jalil Perkasa 19 Bukit Jalil, 57000, Kuala Lumpur, Malaysia

    Kit-Kay Mak & Mallikarjuna Rao Pichika

  4. Department of Chemistry, Krishna University, Machilipatnam, Andhra Pradesh, 521001, India

    Mandava Venkata Basaveswara Rao

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  1. Sivanath Musunuri
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  2. Reddymasu Sreenivasulu
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  3. Kit-Kay Mak
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  4. Mallikarjuna Rao Pichika
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  5. Mandava Venkata Basaveswara Rao
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Correspondence to Mandava Venkata Basaveswara Rao.

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Mallikarjuna Rao Pichika gave suggestions regarding towards the designing of scheme.

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Musunuri, S., Sreenivasulu, R., Mak, KK. et al. Synthesis of quinozilinium fluoroborate salts from harmine. Carbon Lett. 31, 297–305 (2021). https://doi.org/10.1007/s42823-020-00165-7

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  • DOI: https://doi.org/10.1007/s42823-020-00165-7

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