Inflammation is a major regulator of drug metabolizing enzymes and transporters: Consequences for the personalization of drug treatment
Keywords
Inflammation
Drug metabolism
Drug transporters
Personalized medicine
Pharmacokinetics
Therapeutic drug monitoring
Abbreviations
ABC
ATP binding cassette
APP
acute phase protein
AUC
area under the curve
C/D
concentration/dose ratio
CKD
chronic kidney disease
Cmax
maximal concentration
Cmin
trough concentration
CAR
constitutive androstane/active receptor
CRP
C reactive protein
CYP
cytochrome P450
DAMP
damage-associated molecular pattern
DMET
drug metabolizing enzymes and transporters
FXR
farnesoid X receptor
IFN
interferon
IL
interleukin
LPS
lipopolysaccharide
MAPK
MAP kinases
MEGX
monoethylglycinexylidide
MPA
mycophenolic acid
NO
nitric oxide
PAMP
pathogen-associated molecular pattern
PPAR
peroxisome proliferator activation receptor
PXR
pregnane X receptor
RXR
retinoid X receptor-α
SLC
solute carriers
TDM
therapeutic drug monitoring
TLR
toll like receptor
TNF-α
tumor necrosis factor α
UDP-GT
UDP-glucuronyl transferase
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