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A review on synthesis and biomedical applications of polyglycolic acid

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Abstract

Poly(glycolic acid) (PGA) is an essential biopolymer due to its thermal and mechanical properties and biodegradability which provide utility for medical applications and renewable industry. For biomedical applications, production of PGA with high molecular weight is an essential factor to possess adequate mechanical stability. Primary pathways for PGA synthesis are ring-opening polymerization of glycolide (ROP), direct polycondensation of glycolic acid, and solid-state polycondensation of halogen acetates. For PGA synthesis, different systems have been developed with using varying parameters including catalysis, initiators, solvents, and reaction temperature. This review summarizes the different synthesis pathways and physicochemical properties of PGA. Biomedical applications of PGA are also discussed.

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Acknowledgments

We gratefully acknowledge the financial support by Suleyman Demirel University BAP (TSG-2018-6749 Project).

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Authors and Affiliations

  1. Faculty of Medicine, Department of Pharmacology, Medicine, Medical Device and Dermocosmetic Research and Application Laboratory-IDAL, Suleyman Demirel University, 32260, Isparta, Turkey

    Kamil Budak, Oguz Sogut & Umran Aydemir Sezer

  2. Department of Regenerative Medicine, Suleyman Demirel University, Institute of Health Sciences, 32200, Isparta, Turkey

    Umran Aydemir Sezer

  3. YETEM, Innovative Technologies Research and Application Center, Suleyman Demirel University, 32260, Isparta, Turkey

    Umran Aydemir Sezer

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  1. Kamil Budak
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  2. Oguz Sogut
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Correspondence to Umran Aydemir Sezer.

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Budak, K., Sogut, O. & Aydemir Sezer, U. A review on synthesis and biomedical applications of polyglycolic acid. J Polym Res 27, 208 (2020). https://doi.org/10.1007/s10965-020-02187-1

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