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Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis

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Abstract

Background

Amyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS.

Methods

PubMed, Web of Science, and Embase databases were systematically searched for genome-wide association studies or case–control studies published up to March 28, 2020, on the association between Pro34Ser variant and risk of ALS. Data from eligible studies were extracted and analyzed.

Results

Twelve case–control studies involving 7442 patients with sporadic ALS and 75,371 controls were analyzed. The Pro34Ser variant was not associated with increased risk of ALS disease based on fixed-effects meta-analysis (Pro34Ser-positive vs Pro34Ser-negative: OR 1.23, 95% CI 0.90 to 1.69, P = 0.201).

Conclusion

Existing evidence suggests that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants. However, our results ought to be validated using large, well-designed studies, especially in Asian and African populations.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Acknowledgements

Writing and revision: Pingping Ning.

Funding

This work was supported by the Sichuan application basic research project (20YYJC0146).

Author information

Author notes

  1. Baiyuan Yang, Chenghui Yang and Junwei Ren contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Chengdu Seventh People’s Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China

    Baiyuan Yang, Chengqing Zhong, Keting Liu, Liusha Zhao, Li Li, Han Wang & Mingling Zhu

  2. Department of Psychosomatic Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People’s Hospital, 32# West. Section 2, 1st RingRoad, Chengdu, 610072, Sichuan Province, China

    Chenghui Yang

  3. Department of Neurology, Fuling Central Hospital of Chongqing City, No.2, Gaosuntang Road, Fuling District, Chongqing, 408000, China

    Junwei Ren

  4. Department of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM, 81, Ba Yi Road, Wenjiang, Chengdu, 611135, Sichuan Province, China

    Zhenfang Lin

Authors
  1. Baiyuan Yang
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  2. Chenghui Yang
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  10. Zhenfang Lin
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Contributions

Conceptualization: Baiyuan Yang, Chenghui Yang, Junwei Ren, and Zhenfang Lin; Methodology: Baiyuan Yang, Chenghui Yang, and Chengqing Zhong; Formal analysis and investigation: Keting Liu, Liusha Zhao, Li Li, Han Wang, and Mingling Zhu; Writing-original draft preparation: Baiyuan Yang, Chenghui Yang, and Junwei Ren; Writing-review and editing: Baiyuan Yang and Zhenfang Lin; Supervision: Zhenfang Lin.

Corresponding author

Correspondence to Zhenfang Lin.

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The code used and/or analyzed during the current study is available from the corresponding author on reasonable request.

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Heading

1. This manuscript provides what we believe to be the first report of the association between CHCHD10 Pro34Ser variant and risk of amyotrophic lateral sclerosis.

2. This manuscript demonstrated that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants.

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Yang, B., Yang, C., Ren, J. et al. Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis. Neurol Sci 42, 625–631 (2021). https://doi.org/10.1007/s10072-020-04579-z

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  • DOI: https://doi.org/10.1007/s10072-020-04579-z

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