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Serum level of lipoprotein-associated phospholipase A2 is a potential biomarker of vertebrobasilar dolichoectasia and its progression to cerebral infarction

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Abstract

Background

There are no effective therapies to prevent the occurrence and progression of vertebrobasilar dolichoectasia (VBD). In this study, we investigated the relationship between serum levels of lipoprotein-associated phospholipase A2 (Lp-PLA2) and the occurrence and progression of VBD.

Methods

Sixty (60) cases without VBD and ischemia stroke were considered as Group A, 100 cases with VBD were further divided into Group B (VBD without ischemic stroke, n = 54) and Group C (VBD with first ever acute posterior circulation ischemic stroke, n = 46). Demographic data (such as gender and age) and past medical history (such as hypertension, diabetes, and smoking history) were collected. The levels of serum low-density lipoprotein cholesterol (LDL-C), hypersensitivity C reactive protein (hs-CRP), glycosylated hemoglobin (HbAlc), homocysteine (HCY), uric acid (UA), fibrinogen (Fib), and Lp-PLA2, etc. were measured. Logistic regression analysis was used to assess the related factors of VBD and ischemic stroke secondary to VBD.

Results

Logistic multivariate regression analysis showed that only age and the level of serum Lp-PLA2 were significantly higher in group B than those in group A (P < 0.012, P < 0.001, respectively), however, only the level of serum Lp-PLA2 was significantly higher in group C than those in group B (P < 0.001).

Conclusions

The serum marker Lp-PLA2 is an independent risk factor for the occurrence of VBD and the progression of VBD to posterior circulation ischemic stroke. Whether intervening on atherosclerosis could prevent the occurrence and development of VBD needs to be further studied.

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Author notes

  1. Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang and Chunchun Chen contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, The Affiliated Yue Bei People’s Hospital of ShantouUniversity Medical College, Shaoguan, 512025, Guangdong, People’s Republic of China

    Yuan Liu, Jinhua Zhu, Xuhui Deng, Zhi Yang & Feiqi Zhu

  2. Department of Neurology, The Third People’s Hospital of Hangzhou, Hangzhou, 310009, Zhejiang, People’s Republic of China

    Yuan Liu

  3. Cognitive Impairment Ward of Neurology Department, the Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, 518001, Guangdong, People’s Republic of China

    Chunchun Chen & Feiqi Zhu

  4. Department of Neurology, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, Guangxi, People’s Republic of China

    Shuxuan Huang

  5. Department of Neurology, Shunde Hospital of Southern Medical University, Shunde, Foshan, 528300, Guangdong, People’s Republic of China

    Lue Chen

  6. Department of Cardiology, The Third Affiliated Hospital of Shenzhen University Medical College, Shenzhen, 518001, Guangdong, People’s Republic of China

    Ying Ma

  7. Department of Psychiatry, The First Affiliated Hospital of Jinan University, Guangzhou, 510632, Guangdong, China

    Weifeng Lin

Authors
  1. Yuan Liu
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  2. Jinhua Zhu
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  3. Xuhui Deng
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  9. Weifeng Lin
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  10. Feiqi Zhu
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Correspondence to Feiqi Zhu.

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This project was supported by the College Students Innovative Training Planning Project of Guangdong Province, Education Department (No. 201410560092) and this work was also supported by Sanming Project of Medicine in Shenzhen (SZSM201801014).

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Liu, Y., Zhu, J., Deng, X. et al. Serum level of lipoprotein-associated phospholipase A2 is a potential biomarker of vertebrobasilar dolichoectasia and its progression to cerebral infarction. Neurol Sci 42, 599–605 (2021). https://doi.org/10.1007/s10072-020-04563-7

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  • DOI: https://doi.org/10.1007/s10072-020-04563-7

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