Abstract
Talaromyces marneffei is an important opportunistic pathogen mainly afflicting the HIV-infected patients, in rare instance, it could cause infection in non-HIV-infected individuals. We report a 51-year-old Chinese woman who, with histories of SLE for 14 years and disseminated talaromycosis for 4 years, occurred partial intestinal obstruction that was demonstrated to be caused by Talaromyces marneffei infection. The randomly amplified polymorphic DNA results of paraffin-embedded tissues from both the present episode and the previous infection suggested that the present infection was a recurrent. The patient was performed excision of involved intestine and treated with oral itraconazole at a daily dose of 400 mg for 3 months, leading to an excellent response. However, she died with unknown reason more than a year later. We also reviewed the literature on Talaromyces marneffei infection associated with SLE as well as intestinal talaromycosis alone.
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The authors sincerely thank the patient and her husband who signed the informed consents and agreed our publication.
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ZYK, LJY and LJH conceived of the study, participated in clinical management of the patient, reviewed the literature on the item and drafted the manuscript. WHH reviewed the literature, drafted and corrected the manuscript. LS participated the diagnosis, contributed to PCR and analyzed the data, drafted and corrected the manuscript. LDQ made the correct diagnosis, participated in clinical management of the patient, conceived of the study, reviewed the literature on the item and drafted the manuscript. All authors read and approved the final manuscript and agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. All authors read and approved the final manuscript.
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The study was approved by the Ethics Committee of The First Affiliated Hospital, Sun Yat-sen University. The written consents to participate the study have been obtained from the patient before she died and also from her husband after the patient died as well.
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Written informed consents for publication of the clinical details and clinical images were obtained from the individual patient before she died and also from the patient’s husband before we submitted the present manuscript. A copy of the written consent is available for review by the Editor-in-Chief of this journal.
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Zhao, YK., Liu, JY., Liu, JH. et al. Recurrent Talaromyces marneffei Infection Presenting with Intestinal Obstruction in a Patient with Systemic Lupus Erythematosus. Mycopathologia 185, 717–726 (2020). https://doi.org/10.1007/s11046-020-00469-2
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DOI: https://doi.org/10.1007/s11046-020-00469-2