Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

IMMUNE CELL PROTEOMICS

The active inner life of naive T cells

Nature Immunology volume 21, pages 827–828 (2020)Cite this article

Subjects

Quantitative systems-level proteomics is cleverly used to reveal a dynamic program of protein turnover in naive and memory CD4+ T cells that, alongside a stockpile of metabolic protein machinery, poises the cells for activation.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Translational dynamics and protein synthetic capacity of naive and activating T cells.

References

  1. Wolf, T. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0714-5 (2020).

    Article  PubMed  Google Scholar 

  2. Geiger, R. et al. Cell 167, 829–842.e13 (2016).

    Article  CAS  Google Scholar 

  3. Howden, A. J. M. et al. Nat. Immunol. 20, 1542–1554 (2019).

    Article  CAS  Google Scholar 

  4. Tan, H. et al. Immunity 46, 488–503 (2017).

    Article  CAS  Google Scholar 

  5. Voisinne, G. et al. Nat. Immunol. 20, 1530–1541 (2019).

    Article  CAS  Google Scholar 

  6. Ricciardi, S. et al. Cell Metab. 28, 895–906.e5 (2018); erratum 28, 961 (2018).

  7. Russ, B. E. et al. Immunity 41, 853–865 (2014).

    Article  CAS  Google Scholar 

  8. Salerno, F. et al. Nat. Immunol. 19, 828–837 (2018).

    Article  CAS  Google Scholar 

  9. Marchingo, J. M., Sinclair, L. V., Howden, A. J. & Cantrell, D. A. Elife 9, e53725 (2020).

    Article  Google Scholar 

  10. Merkley, S. D., Chock, C. J., Yang, X. O., Harris, J. & Castillo, E. F. Front. Immunol. 9, 2914 (2018).

    Article  CAS  Google Scholar 

  11. Macallan, D. C., Busch, R. & Asquith, B. Curr. Opin. Syst. Biol. 18, 77–86 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Cell Signalling and Immunology Division, School of Life Sciences, University of Dundee, Dundee, UK

    Julia M. Marchingo & Doreen A. Cantrell

Authors
  1. Julia M. Marchingo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Doreen A. Cantrell
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Doreen A. Cantrell.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Marchingo, J.M., Cantrell, D.A. The active inner life of naive T cells. Nat Immunol 21, 827–828 (2020). https://doi.org/10.1038/s41590-020-0726-1

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41590-020-0726-1

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing