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Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI

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Abstract

An efficient method for the synthesis of highly functionalized piperidines via one-pot domino reaction of β-ketoesters, aromatic aldehydes, and aromatic amines was reported. This multicomponent coupling was catalyzed by TMSI in methanol at room temperature, giving desired substituted pyridines in moderate to good yields.

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Acknowledgements

We gratefully acknowledge financial support from the National Natural Science Foundation of China (Grant No. 51604207, 51674183), the Natural Science Foundation of Hubei Province, China (Grant No. 2018CFB605), the Shandong Provincial Education Department, China (Grant No. J18KB083), the Qingchuang Talent Incubation Program from Colleges and universities in Shandong Province (Grant No. 2019) and the Funded by Ship Control Engineering and Intelligent Systems Engineering Technology Research Center of Shandong Province and Ship Motion Control and Systems Engineering Technology Research center of Weihai, China (Grant No. SSCC-2018-0001 and SSCC-2019-0005).

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Authors and Affiliations

  1. Weihai Ocean Vocational College, Weihai, 264300, China

    Lisha Wu & Yinta Li

  2. Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai, 264300, China

    Shiqiang Yan & Wensheng Wang

  3. Colledge of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China

    Shiqiang Yan

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  1. Lisha Wu
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Wu, L., Yan, S., Wang, W. et al. Multicomponent reaction for the synthesis of highly functionalized piperidine scaffolds catalyzed by TMSI. Res Chem Intermed 46, 4311–4322 (2020). https://doi.org/10.1007/s11164-020-04208-6

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