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Model lipid systems and their use to evaluate the phase state of biomembranes, their mechanical properties and the effect of non-conventional antibiotics: the case of daptomycin

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Abstract

The lipid bilayer is the basis of the structure and function of the cell membrane. The study of the molecular phenomena that affect biological membranes has a great impact on the understanding of cellular physiology. To understand these phenomena, it has become increasingly necessary to develop simple synthetic models that allow the most basic details of such processes to be reproduced. In this short communication, we took advantage of the properties of two well-established lipid model systems, GUVs and SLBs, with compositions mimicking the cell membrane present in mammals and bacteria, to study the thermotropic phase behavior of lipids as well as the effect of daptomycin, a cyclic lipopeptide used as an antibiotic. The study of mechanical and thermodynamical properties of these model systems could contribute to establish a theoretical framework to develop more efficient strategies for biological control.

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Authors and Affiliations

  1. Instituto Tecnológico de Educación Superior, Zapopan, 45138, Jalisco, Mexico

    Daniel Balleza

  2. CNR-Nanoscience Institute-S3, Via Campi 213/A, 41125, Modena, Italy

    Andrea Mescola & Andrea Alessandrini

  3. Dipartimento di Scienze Fisiche, Matematiche e Informatiche, Università di Modena e Reggio Emilia, Via Campi 213/A, 41125, Modena, Italy

    Andrea Alessandrini

Authors
  1. Daniel Balleza
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  2. Andrea Mescola
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  3. Andrea Alessandrini
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Contributions

DB, AM, and AA designed research’s strategy and performed experiments. All authors analyzed the data and contributed to the manuscript writing. No potential competing interest was reported by the authors.

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Correspondence to Daniel Balleza.

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Balleza, D., Mescola, A. & Alessandrini, A. Model lipid systems and their use to evaluate the phase state of biomembranes, their mechanical properties and the effect of non-conventional antibiotics: the case of daptomycin. Eur Biophys J 49, 401–408 (2020). https://doi.org/10.1007/s00249-020-01445-w

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  • DOI: https://doi.org/10.1007/s00249-020-01445-w

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