Abstract
Arsenic exposure could induce apoptosis and cause related cancer. It was reported that p38 signaling pathway played a key transcriptional regulatory factor in arsenic-induced apoptosis. However, there were certain disputable questions about this point of opinion. Therefore, the relationship between p38 signaling pathway and arsenic-induced apoptosis was systematically reviewed and analyzed by meta-analysis. Twelve essays were analyzed with StataSE15.0 and Review Manager 5.3. The regulatory variables, such as normal cells and cancer cells, arsenic exposure time and exposure dose were analyzed by the subgroup analysis. The comprehensive effects were compared and analyzed by SMD method. Publication bias, the monolithic impact and heterogeneity were inspected. Subgroup analysis showed, when arsenic exposure was ≥ 5 μmol/l, the expression of Bcl-2 and Bax was down-regulated and the expression of p38 and Caspase-3 was up-regulated. When arsenic exposure was < 5 μmol/l, the expression of Bcl-2, Bax, p38 and Caspase-3 was up-regulated. Arsenic exposure time (≥ 48 h) or arsenic exposure dose (≥ 5 μmol/l or < 5 μmol/l) can promote the expression of p38. Arsenic exposure time was ≥ 48 h or exposure dose was < 5 μmol/l in cancer cells, arsenic exposure dose was ≥ 5 μmol/l or exposure time was < 48 h in normal cells, and they are statistically significant in the expression of p38. This study evaluates the role of p38 signaling pathway in arsenic-induced apoptosis, which is helpful to provide theoretical basis for the differentiation of arsenic-induced injury and the therapeutic mechanism of arsenic-induced apoptosis.
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Funding was provided by National Natural Science Foundation of China (NSFC), Numbers: 81860560, 81660835 and 81160336, and the open project of State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University (FAMP201802K).
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LWU did the most of the paper on meta-analysis; Dr. PL and XL made contributions on data collection and reviewed the methods and results and revised the manuscript. All authors read and approved the final manuscript.
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Wu, L., Li, X., Wei, S. et al. Relationship between p38 signaling pathway and arsenic-induced apoptosis: a meta-analysis. Environ Geochem Health 43, 1213–1224 (2021). https://doi.org/10.1007/s10653-020-00646-8
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DOI: https://doi.org/10.1007/s10653-020-00646-8