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Cervinomycins C1-4 with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980

The Journal of Antibiotics volume 73, pages 812–817 (2020)Cite this article

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ABSTRACT

Polycyclic xanthones are secondary metabolites from actinomycetes and cervinomycin A and B are bioactive 26-membered polycyclic xanthones from Streptomyces sp. CPCC 204980. Herein, we report cervinomycins C1-4 (1–4) from the same strain. The structures of 1–4 were determined by 1D- and 2D-NMR, or single-crystal X-ray diffraction. Compounds 1–4 feature the open or loss of A (oxazolidine) ring in their angular polycyclic framework compared with cervinomycin B. Compounds 1–4 showed potent cytotoxicity against human cancer cell lines HCT116 and BxPC-3, with IC50 at 0.9–801.0 nM and strong anti-Gram-positive bacterial activity.

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Acknowledgements

We thank colleagues at the Nuclear Magnetic Resonance Center (Institute of Materia Medica, CAMS & PUMC) and Analytical Center of Drugs (Institute of Medicinal Biotechnology, CAMS & PUMC) for the NMR, MS, and CD analyses. This work was supported by CAMS Initiative for Innovative Medicine (CAMS-I2M-1-012), National Natural Science Foundation of China (81573328), Drug Innovation Major Project (2018ZX09711-001), and National Infrastructure of Microbiological Resources (No. NIMR-2018-3).

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  1. These authors contributed equally: Xiaowen Hu, Wei Sun

Authors and Affiliations

  1. NHC Key Laboratory of Biotechnology of Antibiotics, CAMS Key Laboratory of Synthetic Biology for Drug Innovation, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Xiaowen Hu, Wei Sun, Shufen Li, LinLi Li, Liyan Yu, Hongyu Liu, Xuefu You, Bingya Jiang & Linzhuan Wu

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  1. Xiaowen Hu
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Hu, X., Sun, W., Li, S. et al. Cervinomycins C1-4 with cytotoxic and antibacterial activity from Streptomyces sp. CPCC 204980. J Antibiot 73, 812–817 (2020). https://doi.org/10.1038/s41429-020-0342-1

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