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Gender difference of association between plasma N-terminal pro-atrial natriuretic peptide and metabolic syndrome

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Abstract

Purpose

The natriuretic peptides (NPs) system, and mainly atrial natriuretic peptide (ANP), plays a key role in human metabolism and cardiometabolic disorders. Due to differences in NP levels and in prevalence of metabolic syndrome (MetS) between men and women, we aimed to explore the gender difference of association between N-terminal pro-atrial natriuretic peptide (NT-proANP) and MetS in a general population in China.

Methods

Participants’ weight, height, waist circumference, blood pressure, plasma NT-proANP, and other traditional biomarkers were measured. Multivariate logistic regression models were used to determine the association between plasma NT-proANP and MetS, and the odds ratio (OR) and 95% confidence interval (CI) were calculated for men and women, respectively.

Results

Among 2203 participants, 1361 (61.78%) were women, 687(30.77%) participants had MetS, and the average age was 53 years. Women had a higher level of NT-proANP than men. However, adjusted logistic regression demonstrated that men in the upper quartile group of NT-proANP had 0.60 (95% CI 0.39–0.92) times the risk of having MetS, while women in the upper quartile group had 1.10 (95% CI 0.77–1.56) times the risk of having MetS compared to the lower quartile group. Furthermore, with the increase of the level of NT-proANP, the ORs showed a declining trend in men (P = 0.017), but it was not statistically significant among women (P = 0.700).

Conclusions

There are gender differences in the relationship between NT-proANP and MetS, while an inverse association between plasma NT-proANP and MetS in men suggests that higher levels of NT-proANP may be a protective factor for MetS.

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Acknowledgments

We express our deep appreciation to the participants in this study and would also like to thank all members of the staff of the Center for Disease Prevention and Control of Gusu district for their support and assistance.

Availability of data and material

The data are available on request from the corresponding author at penghao@suda.edu.cn.

Funding

This study was supported by the National Natural Science Foundation of China (NO. 81903384), the Natural Science Foundation of Jiangsu Province (NO. BK20180841), and the Suzhou Science and Technology Project (NO. SS201853), and a project of the Priority Academic Program Development of Jiangsu Higher Education Institutions, China. The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.

Author information

Author notes

  1. Hongmei Li and Hao Peng contributed equally to this work.

Authors and Affiliations

  1. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China

    Qianlan Guo, Yan He, Hongmei Li & Hao Peng

  2. Center for Disease Prevention and Control of Gusu District, Suzhou, China

    Qiu Zhang

  3. Department of Neurology, Second Affiliated Hospital of Soochow University, Suzhou, China

    Jijun Shi

Authors
  1. Qianlan Guo
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Contributions

Qianlan Guo: Drafted the initial manuscript, made data analysis, and approved the final manuscript as submitted.

Qiu Zhang: Collected the study data, added in data analysis, critically reviewed the manuscript, and approved the final manuscript as submitted.

Yan He: Collected the study data, detected biomarkers, critically reviewed the manuscript, and approved the final manuscript as submitted.

Jijun Shi: Collected the study data, detected biomarkers, critically reviewed the manuscript, and approved the final manuscript as submitted.

Hongmei Li: Supervised the study implementation, study design, and analysis plan; revised the initial manuscript; and approved the final manuscript as submitted.

Hao Peng: Supervised the study implementation, study design, and analysis plan; revised the initial manuscript; and approved the final manuscript as submitted.

Corresponding authors

Correspondence to Hongmei Li or Hao Peng.

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The protocols of this study were approved by the Soochow University Ethics Committee.

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All participants signed the informed consent and participated in this study.

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Guo, Q., Zhang, Q., He, Y. et al. Gender difference of association between plasma N-terminal pro-atrial natriuretic peptide and metabolic syndrome. Hormones 19, 541–548 (2020). https://doi.org/10.1007/s42000-020-00222-w

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  • DOI: https://doi.org/10.1007/s42000-020-00222-w

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