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Smart Nanocomposites Based on Fe–Ag and Fe–Cu Nanopowders for Biodegradable High-Strength Implants with Slow Drug Release

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Abstract

The present paper deals with the development of dense Fe–Ag and Fe–Cu high-strength nanocomposites from blends of nanocomposite powders employing cold sintering (high-pressure consolidation). Nanocomposite powders were obtained by high-energy attrition milling of micron-scale powder of carbonyl iron (Fe) and nanosized silver oxide powder (Ag2O) as well as of nanopowders of Fe and cuprous oxide (Cu2O). Phase identification was done by X-ray diffraction. Microstructure was viewed in a high-resolution scanning electron microscope. Compacts with ~70% theoretical density were annealed in hydrogen to reduce silver and cuprous oxides to metals and to remove oxide layers from the powder particle surface. This was followed by cold sintering, i.e. consolidation in a high-pressure gradient at ambient temperature. The obtained data on the specimen density were analyzed depending on the applied pressure in the range 0.25–3.00 GPa. At the pressure 3.00 GPa, all the nanocomposites are sintered to more than 95% theoretical density. The compositions demonstrate high mechanical properties in three-point bending and compression. The nanocomposites were found to have substantially higher mechanical properties as compared to composites with micron-scale grains. It was revealed that Fe–Ag and Fe–Cu nanocomposites have a higher ductility as compared to nanostructured Fe, which is due to more plastic Ag and Cu phases in the nanocomposites as compared to the Fe phase. It was shown that loading of antibiotic Vancomycin into the interconnected nanopore system of cold-sintered nanocomposites results in nanoencapsulation of the drug and its slow release from the nanocomposite.

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REFERENCES

  1. Ovidko, I.A., Valiev, R.Z., and Zhu, Y.T., Review on Superior Strength and Enhanced Ductility of Metallic Nanomaterials, Progr. Mater. Sci., 2018, vol. 94, pp. 462–540.

  2. Lenel, F.V., Powder Metallurgy: Principles and Applications, Princeton, NJ, USA: MPIF, 1980.

  3. Gutmanas, E.Y., Materials with Fine Microstructures by Advanced Powder Metallurgy, Progr. Mater. Sci., 1990, vol. 34, pp. 261–366.

  4. Suryanarayana, C., Mechanical Alloying and Milling, Progr. Mater. Sci., 2001, vol. 46, pp. 1–184.

  5. Ma, E., Alloys Created between Immiscible Elements, Progr. Mater. Sci., 2005, vol. 50, pp. 413–509.

  6. Herr, U., Ying, J., Gonser, U., and Gleiter, H., Alloy Effects in Consolidated Binary Mixtures of Nanometer-Sized Crystals Investigated by Mossbauer Spectroscopy,Solid State Comm., 1990, vol. 76, pp. 197–202.

  7. Gutmanas, E.Y., Rabinkin, A., and Roitberg, M., Cold Sintering under High Pressure, Scripta Metall., 1979, vol. 13, pp. 11–15.

  8. Gutmanas, E.Y., Trusov, L.K., and Gotman, I., Consolidation, Microstructure and Mechanical Properties of Nanocrystalline Metal Powders, Nanostruct. Mater., 1994, vol. 4, pp. 893–901.

  9. Karwan-Baczewska, J., Gotman, I., Gutmanas, E.Y., and Shapiro, M., Small Particles with Better Contacts Make Nanocomposites Kings of Conductivity, Metal. Powder Rep., 2005, vol. 60(6), pp. 28–34.

  10. Toshima, N. and Yonezawa, T., Bimetallic Nanoparticles—Novel Materials for Chemical and Physical Applications,New J. Chem., 1998, vol. 22, pp. 1179–1201.

  11. Gleiter, H., Nanocrystalline Materials,Progr. Mater. Sci., 1989, vol. 33, pp. 223–315.

  12. Kotov, Y.A., Electric Explosion of Wires as a Method for Preparation of Nanopowders, J. Nanoparticle Res., 2003, vol. 5, pp. 539–550.

  13. Lerner, M.I., Pervikov, A.V., Glazkova, E.A., Svarovskaya, N.V., Lozhkomoev, A.S., and Psakhie, S.G., Structures of Binary Metallic Nanoparticles Produced by Electrical Explosion of Two Wires from Immiscible Elements, Powd. Technol., 2016, vol. 288, pp. 371–378.

  14. Lerner, M., Psakhie, S.G., Lozhkomoev, A.S., Sharipova, A.F., Pervikov, A.V., Gotman, I., and Gutmanas, E.Y., Fe-Cu Nanocomposites by High Pressure Consolidation of Powders Prepared by Electric Explosion of Wires,Adv. Eng. Mater., 2018, vol. 20, article No. 1701024, pp. 1–6.

  15. Segal, V.M., Equal Channel Angular Extrusion: From Macromechanics to Structure Formation, Mater. Sci. Eng. A, 1999, vol. 271, pp. 322–333.

  16. Valiev, R.Z., Estrin, Y., Horita, Z., Langdon, T.G., Zechetbauer, M.J., and Zhu, T.T., Producing Bulk Ultrafine-Grained Materials by Severe Plastic Deformation: Ten Years Later, JOM, 2016, vol. 68, pp. 1216–1226.

  17. Bachmaier, A. and Pippan, R., Generation of Metallic Nanocomposites by Severe Plastic Deformation, Int. Mater. Rev., 2013, vol. 58, pp. 41–62.

  18. Viswanathan, V., Laha, T., Balani, K., Agarwal, A., and Seal, S., Challenges and Advances in Nanocomposite Processing Techniques, Mater. Sci. Eng. R, 2006, vol. 54, pp. 121–285.

  19. Botstein, O., Gutmanas, E.Y., and Lawley, A., Stability and Mechanical Behavior of Cold Sintered P/M Aluminium Alloys, Modern Dev. Powder Met. MPIF, 1985, vol. 15, pp. 761–773.

  20. Sharipova, A., Psakhie, S.G., Swain, S.K., Gotman, I., and Gutmanas, E.Y., High-Strength Bioresorbable Fe-Ag Nanocomposite Scaffolds: Processing and Properties, AIP Conf. Proc., 2015, vol. 1683, article No. 020244.

  21. Gutmanas, E.Y., Gotman, I., Sharipova, A., Psakhie, S.G., Swain, S.K., and Unger, R., Drug Loaded Biodegradable Load-Bearing Nanocomposites for Damaged Bone Repair,AIP Conf. Proc., 2017, vol. 1882, article No. 020025.

  22. Sharipova, A., Swain, S.K., Gotman, I., Starosvetsky, D., Psakhie, S.G., Unger, R., and Gutmanas, E.Y., Mechanical, Degradation and Drug-Release Behavior of Nano-Grained Fe-Ag Composites for Biomedical Applications, J. Mech. Behav. Biomed. Mater., 2018, vol. 86, pp. 240–249.

  23. Makarov, C., Gotman, I., Radin, S., Ducheyne, P., and Gutmanas, E.Y., Vancomycin Release from Bioresorbable Calcium Phosphate–Polymer Composites with High Ceramic Volume Fractions,J. Mater. Sci., 2010, vol. 45, pp. 6320–6324.

  24. Makarov, C., Berdicevsky, I., Raz-Pasteur, A., and Gotman, I., In Vitro Antimicrobial Activity of Vancomycin-Eluting Bioresorbable b-TCP-Polylactic Acid Nanocomposite Material for Load-Bearing Bone Repair, J. Mater. Sci. Mater. Med., 2013, vol. 24, pp. 679–687.

  25. Makarov, C., Cohen, V., Raz-Pasteur, A., and Gotman, I., In Vitro Elution of Vancomycin from Biodegradable Oteoconductive Calcium Phosphate–Polycaprolactone Composite Beads for Treatment of Osteomyelitis, Eur. J. Pharm. Sci., 2014, vol. 62, pp. 49–56.

  26. Thomas, M., Ultraviolet and Visible Spectroscopy, Ando, D.J., Ed., England: Wiley, 1996, p. 16.

  27. Swain, S.K., Gotman, I., Unger, R., and Gutmanas, E.Y., Bioresorbable beta-TCP-FeAg Nanocomposites for Load Bearing Bone Implants: High Pressure Processing, Properties and Cell Compatibility, Mater. Sci. Eng. C. Mater. Biol. Appl., 2017, vol. 78, pp. 88–95.

  28. Huang, T., Cheng, J., Bian, D., and Zheng, Y., Fe-Au and Fe-Ag Composites as Candidates for Biodegradable Stent Materials, J. Biomed. Mater. Res. B, 2016, vol. 104, pp. 225–240.

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Funding

The paper is financially supported by the Program of Fundamental Research of the State Academies of Sciences for 2013–2020, Line of Research III.23.

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Authors and Affiliations

  1. Department of Materials Science and Engineering, Technion–Israel Institute of Technology, 32000, Haifa, Israel

    A. F. Sharipova & E. Y. Gutmanas

  2. Institute of Strength Physics and Materials Science, Siberian Branch, Russian Academy of Sciences, 634055, Tomsk, Russia

    A. F. Sharipova & S. G. Psakhie

  3. ORT Braude College, 21982, Karmiel, Israel

    I. Gotman

Authors
  1. A. F. Sharipova
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  2. S. G. Psakhie
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  3. I. Gotman
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  4. E. Y. Gutmanas
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Correspondence to A. F. Sharipova.

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Russian Text © The Author(s), 2019, published in Fizicheskaya Mezomekhanika, 2019, Vol. 22, No. 1, pp. 36–43.

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Sharipova, A.F., Psakhie, S.G., Gotman, I. et al. Smart Nanocomposites Based on Fe–Ag and Fe–Cu Nanopowders for Biodegradable High-Strength Implants with Slow Drug Release. Phys Mesomech 23, 128–134 (2020). https://doi.org/10.1134/S1029959920020046

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  • DOI: https://doi.org/10.1134/S1029959920020046

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