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Use of cyclodextrins to improve the production of plant bioactive compounds

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Abstract

Cyclodextrins are cyclic oligosaccharides consisting of d-glucopyranose units bound via α-(1,4)-glycosidic linkages. They are obtained from starch enzymatic degradation by the action of cyclodextrinases or glycosyltransferases. Among the modified-cyclodextrins, 2-hydroxypropylated and methylated β-cyclodextrins are produced on industrial scale. Particularly, methylated β-cyclodextrins are more suitable than native β-cyclodextrins to form stable inclusion complexes with organic molecules of low molecular weight, making these complexes more soluble in aqueous solutions. Cyclodextrins have often been considered useful carriers of antitumor- and immuno-regulatory drugs, and they have also been used as additives for food industry. It is also important to note that cyclodextrins are used for improving bioactive compound production in plant cell cultures because of cyclodextrins ability as “hosts” of bioactive compounds favoring their accumulation in aqueous media. In fact, the treatment of plant cell cultures with cyclodextrins and their derivatives increases the production of secondary metabolites such as resveratrol, ajmalicine, serpentine, lutein, arachidin, among other antioxidant compounds, enhancing the capability of plant in vitro cultures to produce high levels of different bioactive compounds which have beneficial properties for human health. In addition, metabolomic, transcriptomic, and proteomic studies have been carried out on both control and cyclodextrins-treated cell cultures offering important clues about how cyclodextrins are capable of substantially increasing the production of bioactive compounds in plant in vitro cultures. This review focuses on the effect of cyclodextrins on both bioactive compound production and their accumulation, which could be of great interest for chemical and pharmaceutical industries.

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Fig. 1

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Abbreviations

CD:

Cyclodextrins

DW:

Dry weight

FW:

Fresh weight

GSTU:

Tau class glutathione-S-transferase

ITC:

Isothermal titration calorimetry

MJ:

Methyl jasmonate

NMR:

Nuclear magnetic resonance

ROS:

Reactive oxygen species

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Acknowledgements

This work was supported by the Ministerio de Economía y Competitividad (BIO2017-82374-R) and Fundación Seneca-Agencia de Ciencia y Tecnología de la Región de Murcia (19876/GERM/15).

Authors’ contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Lorena Almagro and Maria Angeles Pedreño. All authors read and approved the final manuscript.

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  1. Department of Plant Biology, Faculty of Biology, University of Murcia, Campus de Espinardo, 30100, Murcia, Spain

    Lorena Almagro & María Ángeles Pedreño

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  1. Lorena Almagro
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  2. María Ángeles Pedreño
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Correspondence to Lorena Almagro.

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Almagro, L., Pedreño, M.Á. Use of cyclodextrins to improve the production of plant bioactive compounds. Phytochem Rev 19, 1061–1080 (2020). https://doi.org/10.1007/s11101-020-09704-6

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