Issue 8, 2020
From the journal:

Nanoscale Advances

A biomimetic yeast shell vaccine coated with layered double hydroxides induces a robust humoral and cellular immune response against tumors†

Dong-qun Liu,‡ab   Shuai Lu,‡a   Lun Zhang,ab   Ling-xiao Zhang, ORCID logo ab   Mei Ji,ab   Xiao-Ge Liu,ab   Zhuo Yu*c  and  Rui-tian Liu ORCID logo *a  

* Corresponding authors

a National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Haidian District, Beijing 100190, China
E-mail: rtliu@ipe.ac.cn
Fax: +86 10 82545025
Tel: +86 10 82545017

b School of Chemical Engineering, University of Chinese Academy of Science, Beijing 100049, China

c Beijing Tsinghua Changgung Hospital, Changping District, Beijing. 102218, China
E-mail: yza02214@btch.edu.cn
Fax: +86 10 56118500
Tel: +86 10 56119544

Abstract

Enhancing both the humoral and cellular immune response for tumor vaccination remains a challenge. Inspired by natural pathogen structures, we took β-glucan particles derived from a baker's yeast cell shell (YS) as a vaccine carrier and danger signal for dendritic cells (DCs), and coated the YS with catanionic layered double hydroxides (LDH) by electrostatic adsorption to form a biomimetic yeast cell particle (YSL). Our experimental results showed that the YSL vaccine efficiently targeted antigen-presenting cells (APCs) and remarkably enhanced antigen cross-presentation, and strongly improved the activation and maturation of DCs. Moreover, the YSL vaccine elicited an extremely high antibody titer and strong antigen-specific cytotoxic T lymphocyte together with mixed Th1/Th17 cellular immune responses and induced marked prophylactic and therapeutic effects against E.G7-OVA tumors in mouse models. These results suggest that YSL, integrating a yeast shell to mimic natural pathogens and LDH with high antigen-loading capacity and lysosome escape, is a promising tumor vaccine platform for rapid, effective and strong induction of both humoral and cellular immune responses.

Graphical abstract: A biomimetic yeast shell vaccine coated with layered double hydroxides induces a robust humoral and cellular immune response against tumors

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Article information

DOI
https://doi.org/10.1039/D0NA00249F
Article type
Paper
Submitted
30 Mar 2020
Accepted
25 Jun 2020
First published
26 Jun 2020
This article is Open Access
Creative Commons BY-NC license

Nanoscale Adv., 2020,2, 3494-3506

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A biomimetic yeast shell vaccine coated with layered double hydroxides induces a robust humoral and cellular immune response against tumors

D. Liu, S. Lu, L. Zhang, L. Zhang, M. Ji, X. Liu, Z. Yu and R. Liu, Nanoscale Adv., 2020, 2, 3494 DOI: 10.1039/D0NA00249F

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