A mitochondrion-targeting Mn(II)-terpyridine complex for two-photon photodynamic therapy

Xinda Yang; Duoteng Zhang; Jie Li; Wenhui Ji; Naidi Yang; Shunxin Gu; Qiong Wu; Qin Jiang; Pengfei Shi; Lin Li

doi:10.1039/D0CC02051F

A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy†

Xinda Yang,‡^a Duoteng Zhang,‡^b Jie Li,*^b Wenhui Ji,^b Naidi Yang,^b Shunxin Gu,^a Qiong Wu,^b Qin Jiang,*^a Pengfei Shi*^a and Lin Li

*^b

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* Corresponding authors

^a School of Chemical Engineering, Jiangsu Key Laboratory of Function Control Technology for Advanced Materials, Jiangsu Ocean University, Lianyungang 222005, China
E-mail: jiangqin@jou.edu.cn, shipf@jou.edu.cn

^b Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Nanjing Tech University (NanjingTech), Nanjing 211816, China
E-mail: iamjli@njtech.edu.cn, iamlli@njtech.edu.cn

Abstract

We developed a mitochondrion-targeting Mn^II-terpyridine complex (MTP) for two-photon photodynamic therapy. MTP was subjected to two-photon excitation in the NIR region to generate ¹O₂ and hence produce a PDT effect. This use of MTP overcame the drawbacks of traditional PDT agents. The Mn^II center of MTP apparently catalyzed the H₂O₂-mediated production of ROS and oxygen, which subsequently promoted the ¹O₂ generation, furthering the PDT effect. Additionally, the mitochondrion targeting of MTP provided a good spatial condition for the generation of ¹O₂, which further promoted the PDT effect.

Chemical Communications

A mitochondrion-targeting Mn(ii)-terpyridine complex for two-photon photodynamic therapy†

Abstract

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A mitochondrion-targeting Mn(II)-terpyridine complex for two-photon photodynamic therapy

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