Elsevier

Materials & Design

Volume 194, September 2020, 108913
Materials & Design

Smart multi-layer PVA foam/ CMC mesh dressing with integrated multi-functions for wound management and infection monitoring

https://doi.org/10.1016/j.matdes.2020.108913Get rights and content
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open access

Highlights

  • A novel multi-layer wound dressing consisting of antimicrobial drug and methylene blue laden polyvinyl alcohol (PVA) foam as well as electronspun sodium carboxymethylcellulose (CMC) surface mesh was prepared.

  • This is the first wound dressing where antibacterial drug (STAC) was combined with laser photodynamic therapy of methylene blue (MB) to achieve near-total eradication of both S. aureus and E. coli bacteria strains.

  • The smart dressing can also present a distinct color change visible to naked eyes, providing timely in situ monitoring of the infection development.

  • CMC offered effective hemostatic function.

Abstract

In this work, a multi-layer wound dressing consisting of polyvinyl alcohol (PVA) foam and electrospun sodium carboxymethylcellulose (CMC) surface mesh was developed and characterized. Antimicrobial drug stearyl trimethyl ammoium chloride (STAC) was loaded into the PVA foam for infection control and the CMC surface mesh offers effective hemostatic function. Additionally, the potential of laser photodynamic response of the loaded methylene blue (MB) and its effect in enhancing the wound dressing's bacterial inhibition has been investigated. The antibacterial drug and laser photodynamic therapy (PDT) were jointly deployed, which demonstrated greater potential in killing both S. aureus and E. coli bacteria strains. In addition, the unique color changing property of MB has enabled real time bacterial infection monitoring of the wound dressing. The multi-layer wound dressing with ideal material combination and unique multifunctionality may be a promising option for wound management in the future healthcare sector.

Keywords

PVA foam
Wound dressing
Antibacterial property
Methylene blue
Photodynamic therapy

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