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Sulthiame add-on treatment in children with epileptic encephalopathy with status epilepticus: an efficacy analysis in etiologic subgroups

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Abstract

Purpose

Sulthiame (STM) has been recommended as an effective antiepileptic drug (AED) in children with epileptic encephalopathy with status epilepticus in sleep (ESES). The aim of this study is to evaluate the efficacy of STM add-on treatment in children with pattern of ESES with respect to the etiologic subgroup.

Methods

Twenty-nine children with ESES pattern with three different etiologic subgroups (epileptic syndromes: 14, structural/infectious: 9, unknown: 6) who were given STM as add-on treatment were included into the study. The efficacy of STM was evaluated in terms of seizure control, electroencephalography (EEG) findings, need of the new AEDs after add-on STM, and behavioral and cognitive improvement.

Results

The range of the follow-up duration after add-on STM treatment was between 5 and 51 months. At the end of 1 year of STM treatment, the most successful electrophysiologic improvement was identified in the well-defined epileptic syndrome group; epileptic syndrome, 71.4% (10/14); structural/infectious, 33.3% (3/9); and unknown, 0% (0/6). Patients who had complete response or persistent ESES pattern at the 3rd month were still in the same condition at the 6th and 12th months. However, the ESES pattern reappeared in 35.2% of the patients who had partial electrophysiological improvement at the 3rd month. In the epilepsy syndrome group, eight out of ten patients who had either complete or partial EEG response after 1 year of STM treatment displayed behavioral and cognitive improvement.

Conclusion

Sulthiame might be a valid add-on treatment of ESES especially in children with epilepsy syndromes.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Child Neurology, Ege University Medical Faculty, 35100, Bornova, Izmir, Turkey

    Seda Kanmaz, Erdem Simsek, Hepsen Mine Serin, Sanem Yilmaz, Gul Aktan, Hasan Tekgul & Sarenur Gokben

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  1. Seda Kanmaz
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Correspondence to Seda Kanmaz.

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This study was approved by the Ege University ethical committee.

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Kanmaz, S., Simsek, E., Serin, H.M. et al. Sulthiame add-on treatment in children with epileptic encephalopathy with status epilepticus: an efficacy analysis in etiologic subgroups. Neurol Sci 42, 183–191 (2021). https://doi.org/10.1007/s10072-020-04526-y

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