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Increased Levels of IL-34 in Acquired Immune-Mediated Neuropathies

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Abstract

Interleukin (IL)-34 is ligand for the colony-stimulating factor (CSF)-1 receptor. This cytokine has fundamental roles the pathogenesis of a number of autoimmune and neurologic disorders. However, its role in the pathogenesis of acute and chronic inflammatory demyelinating polyneuropathies (AIDP and CIDP) has not been assessed yet. We measured serum levels of IL-34 33 CIDP cases, 16 AIDP cases, and 33 control subjects using commercial ELISA kits. IL-34 levels were significantly higher in both AIDP (44.87 ± 4.38) and CIDP (44.87 ± 4.38) groups compared with healthy subjects (30.10 ± 1.05) (P = 0.046 and P = 0.01, respectively). Differences between female subgroups were insignificant. However, levels of this cytokine were significantly higher in male subjects with CIDP compared with male controls (P = 0.042). Thus, levels of this cytokine might be regarded as biomarkers for these kinds of autoimmune disorders. Future studies are needed to verify these results and find the molecular mechanism of participation of IL-34 in the pathogenesis of AIDP/CIDP.

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Funding

The current study was supported by a grant number 9712218216 from Hamadan University of Medical Sciences.

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Authors and Affiliations

  1. Department of Immunology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran

    Sina Rezaei

  2. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Soudeh Ghafouri-Fard

  3. Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan, Iran

    Alireza Komaki & Mohammad Mahdi Eftekharian

  4. Department of Neurology, Hamadan University of Medical Sciences, Hamadan, Iran

    Mehrdokht Mazdeh

  5. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

    Mohammad Taheri

Authors
  1. Sina Rezaei
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  2. Soudeh Ghafouri-Fard
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  3. Alireza Komaki
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  4. Mehrdokht Mazdeh
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  5. Mohammad Taheri
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  6. Mohammad Mahdi Eftekharian
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Corresponding authors

Correspondence to Mohammad Taheri or Mohammad Mahdi Eftekharian.

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The study protocol was approved by ethical committee of Hamadan University of Medical Sciences (IR.UMSHA.REC.1397.948).

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The authors declare they have no conflict of interest.

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Rezaei, S., Ghafouri-Fard, S., Komaki, A. et al. Increased Levels of IL-34 in Acquired Immune-Mediated Neuropathies. J Mol Neurosci 71, 137–141 (2021). https://doi.org/10.1007/s12031-020-01634-4

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  • DOI: https://doi.org/10.1007/s12031-020-01634-4

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