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TUMORIGENIC REPROGRAMMING

Oncogenetic engagement with mechanosensing

Nature Materials volume 19, pages 707–709 (2020)Cite this article

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Reprogramming normal cells into tumour precursors involves complex reconditioning of the tissue microenvironment. Cumulative integration of genetic drivers with extrinsic mechanical inputs is now shown to engage YAP/TAZ to rewire cell mechanics and initiate tumorigenic reprogramming.

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Fig. 1: Mechanical inputs and oncogenic activators forge YAP/TAZ- mediated tumorigenesis.

Change history

  • 02 July 2020

    In the PDF version of this News & Views originally published, Sayan Chakraborty’s ORCID was incorrectly listed as 0000-0003-3849-8038; it should have been 0000-0002-5591-8164. This has now been updated.

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Authors and Affiliations

  1. Institute of Molecular and Cell Biology, Agency for Science, Technology, and Research (A*STAR), Singapore, Singapore

    Sayan Chakraborty & Wanjin Hong

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  1. Sayan Chakraborty
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  2. Wanjin Hong
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Correspondence to Sayan Chakraborty or Wanjin Hong.

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Chakraborty, S., Hong, W. Oncogenetic engagement with mechanosensing. Nat. Mater. 19, 707–709 (2020). https://doi.org/10.1038/s41563-020-0700-1

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