Original ResearchDecreased Colonic Activin Receptor-Like Kinase 1 Disrupts Epithelial Barrier Integrity in Patients With Crohn’s Disease
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Conflicts of interest These authors disclose the following: Nancy L. Allbritton and Yuli Wang have a financial interest in Altis Biosystems. The remaining authors disclose no conflicts.
CRediT Authorship Contributions Takahiko Toyonaga, MD, PhD (Conceptualization: Lead; Formal analysis: Lead; Investigation: Lead; Validation: Lead; Visualization: Lead; Writing – original draft: Lead; Writing – review & editing: Lead); Erin C. Steinbach (Investigation: Supporting); Benjamin P Keith (Data curation: Lead; Formal analysis: Lead; Investigation: Supporting); Jasmine B Barrow (Conceptualization: Supporting; Investigation: Supporting; Resources: Supporting); Matthew R Schaner (Resources: Lead); Elisabeth A Wolber (Resources: Lead); Caroline Beasley (Resources: Lead); Jennifer Huling (Formal analysis: Supporting; Investigation: Supporting; Methodology: Lead; Visualization: Lead); Yuli Wang (Methodology: Lead); Nancy L Allbritton (Methodology: Lead; Supervision: Lead); Nicole Chaumont (Resources: Lead); Timothy S Sadiq (Resources: Lead); Mark J Koruda (Resources: Lead); Animesh Jain (Resources: Supporting); Millie D. Long (Resources: Supporting); Edward L. Barnes (Resources: Supporting); Hans H. Herfarth (Resources: Supporting); Kim L. Isaacs (Resources: Supporting); Jonathan J. Hansen (Resources: Supporting); Michael T. Shanahan (Writing – review & editing: Supporting); Reza Rahbar (Resources: Lead); Terrence S Furey (Data curation: Lead; Formal analysis: Supporting; Funding acquisition: Supporting; Project administration: Supporting; Supervision: Lead; Writing – review & editing: Lead); Praveen Sethupathy (Formal analysis: Supporting; Funding acquisition: Supporting; Project administration: Supporting; Supervision: Lead; Writing – review & editing: Lead); Shehzad Z Sheikh, MD, PhD (Conceptualization: Lead; Formal analysis: Supporting; Funding acquisition: Lead; Methodology: Supporting; Project administration: Lead; Resources: Lead; Supervision: Lead; Validation: Supporting; Writing – review & editing: Lead).
Preprint server: This manuscript was posted to bioRxiv (doi: https://doi.org/10.1101/2020.02.21.960070). Transcript profiling was as follows: nucleotide sequence data sets discussed here are available through Gene Expression Omnibus (GEO) under accession number GSE85499 (RNA-seq; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE85499) and GSE101819 (smRNA-seq; https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE101819).
Funding This work was funded in part through Helmsley Charitable Trust (SHARE Project 2); National Institute of Diabetes and Digestive and Kidney Diseases grants P01 DK094779, 1R01DK104828-01A1, R01DK109559, and P30-DK034987; T32 DK007737 (E.C.S); the Thurston Arthritis Research Center and the National Institute of Allergy and Infectious Diseases Loan Repayment Program (E.C.S.); and Career Development Award (567497) and Research Fellow Award (634239) from the Crohn’s and Colitis Foundation. The University of North Carolina Translational Pathology Laboratory is supported in part by grants from the National Cancer Institute (3P30CA016086).