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TISSUE-RESIDENT CELLS

Type 1 Treg cells act as unexpected helpers

CXCR3+ regulatory T cells, known to limit type 1 immune responses, can promote tissue-resident immunity by providing bioactive transforming growth factor-β to CD8+ T cells.

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Fig. 1: Type 1 Treg cells drive CD8+ TRM development.

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Correspondence to Nicole Joller.

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Joller, N. Type 1 Treg cells act as unexpected helpers. Nat Immunol 21, 720–721 (2020). https://doi.org/10.1038/s41590-020-0710-9

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