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Studying and Assessing the Toxicity of Calcium Oxide Nanoparticles under One-Time Inhalation Exposure

  • NANOBIOLOGY AND GENETICS, OMICS
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Abstract

Under a single 4 hour inhalation exposure to aerosol containing an aqueous suspension of calcium oxide nanoparticles (CaO) in an actual concentration of 6.68 mg/m3, the accumulation of calcium increased in the lungs (by 1.52 times), in the brain (by 1.55 times) and in the liver (by 1.25 times) relative to the control, while exposure to a microdispersed analog in a concentration of 6.37 mg/m3 resulted in an increase in the indicator only in the brain (by 1.27 times). At the same time, the calcium concentration in the brain of animals in the experimental group is higher than in the comparison group (by 1.22 times). After exposure to CaO nano- and microparticles a subarachnoid hemorrhage in the brain tissues was found. The development of pathomorphological changes in the form of lymphoid tissue hyperplasia, eosinophilia, acute arterial plethora, and hemorrhagic lung infarcts, as well as the hydropic and hyaline-drop dystrophy of parenchymal liver tissue was observed only after exposure to CaO nanoparticles. The identified features of the bioaccumulation and pathomorphological changes under inhalation exposure to CaO nanoparticles demonstrate that the studied nanomaterial has a higher level of toxicity in comparison to its microdispersed analog.

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REFERENCES

  1. Benefits and Applications, National Nanotechnology Initiative. http://www.nano.gov/you/nanotechnology-benefits. Accessed January 21, 2020.

  2. A. Sukhanova, S. Bozrova, P. Sokolov, et al., “Dependence of nanoparticle toxicity on their physical and chemical properties,” Nanoscale Res. Lett. 13 (44), 21 (2018). https://doi.org/10.1186/s11671-018-2457-x

    Article  CAS  Google Scholar 

  3. S. Abraham and V. P. Saranthy, “Biomedical applications of calcium oxide nanoparticles - a spectroscopic study,” Int. J. Pharm. Sci. Rev. Res. 49, 121 (2018).

    CAS  Google Scholar 

  4. C. Batt and M. Tortorello, Encyclopedia of Food Microbiology, 2nd ed. (Academic, Elsevier, San Diego, 2014).

    Google Scholar 

  5. Calcium Oxide (CaO) Nanoparticles – Properties, Applications, AZoNano. 2013. http://www.azonano.com/article.aspx?ArticleID=3365. Accessed January 21, 2020.

  6. H. Bai, X. Shen, X. Liu, et al., “Synthesis of porous CaO microsphere and its application in catalyzing transesterification reaction for biodiesel,” Trans. Nonferr. Met. 19, 674 (2009). https://doi.org/10.1016/S1003-6326(10)60130-6

    Article  Google Scholar 

  7. S. Al-Shaibani, “The effect of calcium oxide-nanoparticles on the function of the kidney organ in the rats,” J. Eng. Appl. Sci. 13, 7689 (2018).

    CAS  Google Scholar 

  8. A. R. Butt, S. Ejaz, J. C. Baron, et al., “CaO nanoparticles as a potential drug delivery agent for biomedical applications,” Digest J. Nanomater. Biostruct. 10, 799 (2015).

    Google Scholar 

  9. G. Gedda, S. Pandy, Y.-C. Lin, et al., “Antibacterial effect of calcium oxide nano-plates fabricated from shrimp shells,” Green Chem. 17, 3276 (2015). https://doi.org/10.1039/C5GC00615E

    Article  CAS  Google Scholar 

  10. C. Bhavya, K. Yogendra, K. M. Mahadevan, et al., “Synthesis of calcium oxide nanoparticles and its mortality study on fresh water fish cyprinus carpio,” IOSR J. Environ. Sci., Toxicol. Food Technol. 10 (12), 55 (2016).

    CAS  Google Scholar 

  11. J. Kovrižnych, R. Sotnikova, D. Zeljenkova, et al., “Acute toxicity of 31 different nanoparticles to zebrafish (Danio rerio) tested in adulthood and in early life stages - comparative study,” Interdiscipl. Toxicol. 6 (2), 67 (2013). https://doi.org/10.2478/intox-2013-0012

    Article  CAS  Google Scholar 

  12. Natl. Res. Council of the National Acad., Guide for the Care and Use of Laboratory Animals (Natl. Acad. Press, Washington, DC, 2011).

  13. S. J. Goldstein, J. G. Sacks, C. Lee, et al., “Computed tomographic findings in cerebral arterial ectasia,” Am. J. Neuroradiol., No. 4, 501 (1983).

  14. Kim Jung Hun, Kim Jin Hyoung, J. A. Park, S. W. Lee, et al., “Blood-neural barrier: intercellular communication at glio-vascular interface,” J. Biochem. Mol. Biol. 39, 339 (2006). https://doi.org/10.5483/bmbrep.2006.39.4.339

  15. S. Liu, D. Agalliu, C. Yu, and M. Fisher, “The role of pericytes in blood-brain barrier function and stroke,” Curr. Pharm. Des. 18, 3653 (2012). https://doi.org/10.2174/138161212802002706

    Article  CAS  Google Scholar 

  16. C. Pease, T. Rucker, and T. Birk, “Review of the evidence from epidemiology, toxicology and lung bioavailability on the carcinogenicity of inhaled iron oxide particulates,” Chem. Res. Toxicol. 29, 237 (2016). https://doi.org/10.1021/acs.chemrestox.5b00448

    Article  CAS  Google Scholar 

  17. B. N. Lambrecht and H. Hammad, “The immunology of asthma,” Nat. Immunol. 16, 45 (2015). https://doi.org/10.1038/ni.3049

    Article  CAS  Google Scholar 

  18. I. Petrushanko, N. Bogdanov, E. Bulygina, et al., “Na-K-ATPase in rat cerebellar granule cells is redox sensitive,” Am. J. Physiol., Regul. Integr. Compar. Physiol. 290, R916 (2006). https://doi.org/10.1152/ajpregu.00038.2005

    Article  CAS  Google Scholar 

  19. Medical Biophysics: A textbook for Higher School, 3rd ed., Ed. by V. Samoilov (SpetsLit, St. Petersburg, 2013) [in Russian].

    Google Scholar 

  20. Pathological Anatomy: Textbook, 5th ed., Ed. by A. I. Strukov and V. V. Serov (Litterra, Moscow, 2010) [in Russian].

    Google Scholar 

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Authors and Affiliations

  1. Federal Scientific Center for Medical and Preventive Health Risk Management Technologies, Perm, Russia

    N. V. Zaitseva, M. A. Zemlyanova, M. S. Stepankov & A. M. Ignatova

  2. Perm State National Research University, Perm, Russia

    M. A. Zemlyanova & M. S. Stepankov

  3. Perm National Research Polytechnic University, Perm, Russia

    M. A. Zemlyanova & A. M. Ignatova

Authors
  1. N. V. Zaitseva
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  2. M. A. Zemlyanova
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  3. M. S. Stepankov
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  4. A. M. Ignatova
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Correspondence to M. A. Zemlyanova.

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Zaitseva, N.V., Zemlyanova, M.A., Stepankov, M.S. et al. Studying and Assessing the Toxicity of Calcium Oxide Nanoparticles under One-Time Inhalation Exposure. Nanotechnol Russia 14, 497–503 (2019). https://doi.org/10.1134/S1995078019050148

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  • DOI: https://doi.org/10.1134/S1995078019050148

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