Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie; Taojian Fan; Jusung An; Wonseok Choi; Yanhong Duo; Yanqi Ge; Bin Zhang; Guohui Nie; Ni Xie; Tingting Zheng; Yun Chen; Han Zhang; Jong Seung Kim

doi:10.1039/D0CS00215A

Emerging combination strategies with phototherapy in cancer nanomedicine

Zhongjian Xie,†^ab Taojian Fan,†^a Jusung An,†^c Wonseok Choi,†^c Yanhong Duo,

†^a Yanqi Ge,†^a Bin Zhang,^a Guohui Nie,^a Ni Xie,^a Tingting Zheng,^d Yun Chen,^d Han Zhang

*^a and Jong Seung Kim

*^c

Author affiliations

* Corresponding authors

^a Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Physics and Optoelectronic Engineering, and Otolaryngology Department and Biobank of the First Affiliated Hospital, Shenzhen Second People's Hospital, Health Science Center, Shenzhen University, Shenzhen 518060, P. R. China
E-mail: hzhang@szu.edu.cn

^b Shenzhen International Institute for Biomedical Research, 518116 Shenzhen, Guangdong, China

^c Department of Chemistry, Korea University, Seoul 02841, Korea
E-mail: jongskim@korea.ac.kr

^d Shenzhen Key Laboratory for Drug Addiction and Medication Safety, Department of Ultrasound, Peking University Shenzhen Hospital, Shenzhen, P. R. China

Abstract

Optical techniques using developed laser and optical devices have made a profound impact on modern medicine, with “biomedical optics” becoming an emerging field. Sophisticated technologies have been developed in cancer nanomedicine, such as photothermal therapy and photodynamic therapy, among others. However, single-mode phototherapy cannot completely treat persistent tumors, with the challenges of relapse or metastasis remaining; therefore, combinatorial strategies are being developed. In this review, the role of light in cancer therapy and the challenges of phototherapy are discussed. The development of combinatorial strategies with other therapeutic methods, including chemotherapy, immunotherapy, gene therapy, and radiotherapy, is presented and future directions are further discussed. This review aims to highlight the significance of light in cancer therapy and discuss the combinatorial strategies that show promise in addressing the challenges of phototherapy.

This article is part of the themed collection: 2020 Emerging Investigators

Chemical Society Reviews

Emerging combination strategies with phototherapy in cancer nanomedicine

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