Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

STRUCTURAL BIOLOGY

5-LOX inhibition by natural products

Nature Chemical Biology volume 16, pages 714–715 (2020)Cite this article

Subjects

The enzyme 5-lipoxygenase (5-LOX) initiates the biosynthesis of leukotrienes (LT), potent mediators of the inflammatory response. The first crystal structures of two complexes of inhibitor bound to 5-LOX reveal the functional consequences of the binding, including a change in the regiospecificity toward a 12/15-lipoxygenating enzyme.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: 5-LOX catalyzes the conversion of AA to LT through the formation of 5-HETE as an intermediate.

References

  1. Gilbert, N. et al. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0544-7 (2020).

  2. Kuhn, H., Banthiya, S. & van Leyen, K. Biochim. Biophys. Acta 1851, 308–330 (2015).

    Article  CAS  Google Scholar 

  3. Rubbo, H. et al. Arch. Biochem. Biophys. 324, 15–25 (1995).

    Article  CAS  Google Scholar 

  4. Shah, R., Shchepinov, M. S. & Pratt, D. A. ACS Cent. Sci. 4, 387–396 (2018).

    Article  CAS  Google Scholar 

  5. Trostchansky, A., Bonilla, L., González-Perilli, L. & Rubbo, H. Antioxid. Redox Signal. 19, 1257–1265 (2013).

    Article  CAS  Google Scholar 

  6. Awwad, K. et al. Antioxid. Redox Signal. 20, 2667–2680 (2014).

    Article  CAS  Google Scholar 

  7. Trostchansky, A. et al. Biochemistry 46, 4645–4653 (2007).

    Article  CAS  Google Scholar 

  8. Trostchansky, A. et al. J. Biol. Chem. 286, 12891–12900 (2011).

    Article  CAS  Google Scholar 

  9. Wood, I. et al. Free Radic. Biol. Med. 144, 176–182 (2019).

    Article  CAS  Google Scholar 

  10. González-Perilli, L. et al. Free Radic. Biol. Med. 58, 126–133 (2013).

    Article  Google Scholar 

  11. González-Perilli, L. et al. General Subjects 1861, 1131–1139 (2017).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Bioquímica, Facultad de Medicina, Universidad de la República and Centro de Investigaciones Biomédicas (CEINBIO), Montevideo, Uruguay

    Homero Rubbo & Irene Wood

Authors
  1. Homero Rubbo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Irene Wood
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Homero Rubbo.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Rubbo, H., Wood, I. 5-LOX inhibition by natural products. Nat Chem Biol 16, 714–715 (2020). https://doi.org/10.1038/s41589-020-0568-z

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41589-020-0568-z

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing