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Unexpected Influence of the Neutral Lipid Nature on pH-Regulated Release of Salt from the Anionic Fliposomes

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Abstract

It was found that the substitution of electoneutral dioleoylphosphatidylcholine with dipalmytoylphosphatidylcholine in membrane of anionic fliposomes with molar fraction of pH-sensitive 4,5-bis-dodecylcarbonyl-2-morpholincyclohexanol 0.3 does not result in formation of expected gel-state liposomes. Nevertheless, this change in composition of lipid membrane strongly affects on kinetics of pH-governed release of incapsulated in fliposomes salt.

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Funding

This work was supported by Russian Foundation for Basic Research (project no. 18-29-02080).

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  1. Lomonosov Moscow State University, 119991, Moscow, Russia

    K. M. Imelbaeva & D. A. Stepanova

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  1. K. M. Imelbaeva
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  2. D. A. Stepanova
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Correspondence to D. A. Stepanova.

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Imelbaeva, K.M., Stepanova, D.A. Unexpected Influence of the Neutral Lipid Nature on pH-Regulated Release of Salt from the Anionic Fliposomes. Russ J Gen Chem 90, 731–736 (2020). https://doi.org/10.1134/S107036322004026X

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