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Convenient Synthesis of Novel Chalcone and Pyrazoline Sulfonamide Derivatives as Potential Antibacterial Agents

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Abstract

Novel chalcone sulfonamide derivatives were synthesized starting from benzophenones and aldehydes in 3 steps. Also, (E)-3-(4-chlorophenyl)-1-(4-methoxyphenyl)prop-2-en-1-one was converted to different pyrazoline in four steps. The synthesis of sulfonamides was carried out under solvent-free conditions at room temperature and the products were obtained in high purity after a simple work-up without using any chromatography method for purification. All of the products were evaluated for their in vitro antibacterial activity against Staphylococcus aureus and Escherichia coli.

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ACKNOWLEDGMENTS

We acknowledge financial support from the Shahreza Branch, Islamic Azad University (IAUSH) Research Council. Also, we thank Professor R. F. W. Jackson (Department of Chemistry, The University of Sheffield UK) for helpful comments on the manuscript and S. Bradshaw (Department of Chemistry, The University of Sheffield UK) for recording NMR spectra.

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Authors and Affiliations

  1. Department of Chemistry, Shahreza Branch, Islamic Azad University, 86145-311, Shahreza, Iran

    A. P. S. Bonakdar, A. Sadeghi, H. R. Aghaei & A. R. Massah

  2. Department of Microbiology, Falavarjan Branch, Islamic Azad University, Isfahan, Falavarjan, Iran

    K. Beheshtimaal

  3. Department of Medicinal Chemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, 81746-73461, Isfahan, Iran

    S. M. R. Nazifi

Authors
  1. A. P. S. Bonakdar
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  2. A. Sadeghi
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  3. H. R. Aghaei
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  4. K. Beheshtimaal
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  5. S. M. R. Nazifi
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  6. A. R. Massah
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Corresponding author

Correspondence to A. R. Massah.

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The authors declare that they have no conflict of interest. This article does not contain any studies involving animals or human participants performed by any of the authors.

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The authors declare that they have no conflicts of interest.

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Corresponding author: phone: +98–321-3292522; e-mail: Massah@iaush.ac.ir.

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Bonakdar, A.P., Sadeghi, A., Aghaei, H.R. et al. Convenient Synthesis of Novel Chalcone and Pyrazoline Sulfonamide Derivatives as Potential Antibacterial Agents. Russ J Bioorg Chem 46, 371–381 (2020). https://doi.org/10.1134/S1068162020030048

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  • DOI: https://doi.org/10.1134/S1068162020030048

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