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In vitro study of aripiprazole loading and releasing efficiency of SBA-16

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Abstract

Mesoporous silica (SBA-16) was synthesized by the hydrothermal synthesis route. The structural properties of the synthesized SBA-16 were found out by a small-angle X-ray diffraction technique. Morphological characterization was characterized by scanning electron microscope (SEM) and high-resolution transmission electron microscope (HRTEM). Nitrogen adsorption–desorption isotherm was used to find out surface area, pore size, and pore volume. Aripiprazole was used as a model drug to calculate drug loading efficiency of prepared SBA-16 and their release kinetics was also calculated with the response to three different pH solutions. UV–Visible spectrophotometer was used to find out the absorbance of the sample. The results indicated that the synthesized SBA-16 has high drug loading efficiency with a control release profile.

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Acknowledgements

Author is thankful to UGC, India for the award of SRF to Mr. Atul Kumar and Mr. Narender Ranga for NFSC Fellowship.

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Authors and Affiliations

  1. Department of Materials Science and Nanotechnology, DCRUST, Murthal, Sonipat, 131027, India

    Atul Kumar, Narender Ranga & Surender Duhan

  2. Department of Physics, DCRUST, Murthal, Sonipat, 131027, India

    Surender Duhan

  3. Department of Bio and Nano Technology, GJUS&T, Hisar, Haryana, 125001, India

    Rajesh Thakur

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  1. Atul Kumar
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  2. Narender Ranga
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Correspondence to Surender Duhan.

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Kumar, A., Ranga, N., Duhan, S. et al. In vitro study of aripiprazole loading and releasing efficiency of SBA-16. J Porous Mater 27, 1431–1437 (2020). https://doi.org/10.1007/s10934-020-00910-3

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  • DOI: https://doi.org/10.1007/s10934-020-00910-3

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