Graphene oxide: a green oxidant-acid bifunctional carbon material for the synthesis of functionalized isoindolin-1-ones via formal amide insertion and substitution†
Xiangjun
Peng, 
b
Liangxian
Liu
*a
b
Liangxian
Liu
*a
Abstract
A formal amide insertion and substitution reaction for the synthesis of functionalized isoindolin-1-ones was developed on the basis of graphene oxide (GO) as a green and oxidant-acid bifunctional carbon material. A series of N-acylisoindolin-1-ones were synthesized in good to excellent yields directly from benzoisofurans and nitriles in the presence of GO without the need for any additives or metals.
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