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Immunohistochemical Investigation of Predictive Biomarkers for Mandibular Bone Invasion in Oral Squamous Cell Carcinoma

  • Original Article
  • Published:
Pathology & Oncology Research

Abstract

The accurate preoperative determination of the extent of mandibular resection remains a challenge for the surgeons. The purpose of the present study was to immunohistochemically investigate predictive markers for histological bone invasion of oral squamous cell carcinoma (OSCC). The medical records of primary OSCC patients with mandibular bone contact in preoperative computed tomography scans between January 2003 and December 2017 were retrospectively reviewed and an immunohistochemical investigation was performed. Forty-five OSCC patients with mandibular bone contact radiographically were included in this study. Histopathologically, infiltrative bone invasion was observed in 19 patients (42.2%) and compressive bone invasion in 15 (33.3%). A correlation was noted between the histological pattern of bone invasion and mode of invasion (chi-squared test, p < 0.05). At the tumor surface, a correlation was observed between the expression of IL-6 and bone invasion (the Wilcoxon test, p < 0.05), although the expression was so weak. At the bone contact area, the expression of both ɑ-SMA and OPG correlated with infiltrative bone invasion (ɑ-SMA; the Wilcoxon test, p < 0.05, OPG; p < 0.05). These results suggest that predictive markers for aggressive (infiltrative) bone invasion in OSCC patients with a higher mode of invasion are the expression of ɑ-SMA and OPG.

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Data Availability

The datasets during and/or analysed during the current study available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Dentistry and Oral Surgery, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan

    Takahiko Gibo, Shin-ichi Yamada, Makiko Kawamoto & Hiroshi Kurita

  2. Department of Laboratory Medicine, Shinshu University School of Medicine, 3-1-1, Asahi, Matsumoto, 390-8621, Japan

    Takeshi Uehara

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  1. Takahiko Gibo
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  2. Shin-ichi Yamada
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  3. Makiko Kawamoto
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  4. Takeshi Uehara
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  5. Hiroshi Kurita
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Correspondence to Shin-ichi Yamada.

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This study was approved by the Committee on Medical Research of Shinshu University (No4182).

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Patient consent was not required in this study.

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Gibo, T., Yamada, Si., Kawamoto, M. et al. Immunohistochemical Investigation of Predictive Biomarkers for Mandibular Bone Invasion in Oral Squamous Cell Carcinoma. Pathol. Oncol. Res. 26, 2381–2389 (2020). https://doi.org/10.1007/s12253-020-00826-y

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  • DOI: https://doi.org/10.1007/s12253-020-00826-y

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