Original ResearchInsulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury
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Keywords
IGF-1
Raptor
Rapamycin
Intestinal Repair
Crypt Regeneration
Intestinal Stem Cells
Abbreviations used in this paper
ANOVA
analysis of variance
CBC
crypt base columnar
DPI
days post-irradiation
EDU
5-ethynyl-2´-deoxyuridine
FSC
facultative stem cell
HPI
hours post-irradiation
IGF-1
insulin-like growth factor-1
ISC
intestinal stem cell
mTORC1
mammalian target of rapamycin complex 1
PBS
phosphate-buffered saline
qPCR
quantitative reverse transcriptase polymerase chain reaction
SEM
standard error of the mean
UNIRR
unirradiated controls
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Conflicts of interest The authors disclose no conflicts.
Funding NB was supported by the Cellular & Molecular Biology program, a Rackham International Student Fellowship, and the Bernard L. Maas Fellowship; KPM was supported by the Training Program in Organogenesis NIH T32 HD007505. The research was funded by NIH R01-DK118023 to LCS, R03-DK114656 to KSY, BWF CAMS to KSY, and Core support from the Michigan Gastrointestinal Research Center Grant NIH P30-DK34933.
© 2020 The Authors. Published by Elsevier Inc. on behalf of the AGA Institute.