Regenerative Therapy

Regenerative Therapy

Volume 14, June 2020, Pages 341-343
Regenerative Therapy

Forum Report
Polyurethane foam for skin graft fixation in clinical-relevant ovine burn wound model for wound repair and regeneration research

https://doi.org/10.1016/j.reth.2020.04.007Get rights and content
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open access

Highlights

  • Polyurethane foam was effective for fixation of grafted skin in ovine burn wounds model.

  • Histopathology of ovine grafted skin model was similar to that of human.

  • Ovine is considered as a clinical-relevant animal model for wound regeneration research.

  • The polyurethane foam method can potentially be translated to clinical practice.

Abstract

The availability of clinical-relevant large animal models for research in wound healing study is limited. Although a few reports described the wound dressing fixation method using polyurethane foam in patients, no animal studies were conducted to investigate efficacy of the polyurethane foam in grafted burn wounds. In the present study, we report a simple fixation method of grafted burned skin using polyurethane foam dressing (Allevyn Non-Adhesive, smith & nephew, UK) in a clinically relevant ovine grafted burn wound model. The dressing was removed at postoperative day 7 after skin graft. The grafted skin was completely engrafted without any complications. This method was safe and easy to perform and associated with good engraftment without any complications. We believe that the polyurethane foam fixation method may be successfully used in clinical practice as well as in preclinical studies for grafted burn wound repair and regeneration research.

Keywords

Sheep
Burn wound healing
Autologous skin graft
Allogenous skin graft
Non-adhesive hydrocellular foam dressing
Polyurethane foam

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Peer review under responsibility of the Japanese Society for Regenerative Medicine.