Skip to main content
Log in

Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages

  • Letter to the Editor
  • Published:
Neuroscience Bulletin Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

References

  1. Wang K, Li M, Bucan M. Pathway-based approaches for analysis of genomewide association studies. Am J Hum Genetics 2007, 81: 1278–1283.

    Article  CAS  Google Scholar 

  2. McClay JL, Shabalin AA, Dozmorov MG, Adkins DE, Kumar G, Nerella S, et al. High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction. Genome Biol 2015, 16: 291.

    Article  Google Scholar 

  3. Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, et al. Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005, 102: 15545–15550.

    Article  CAS  Google Scholar 

  4. Moberget T, Doan NT, Alnæs D, Kaufmann T, Córdova-Palomera A, Lagerberg TV, et al. Cerebellar volume and cerebellocerebral structural covariance in schizophrenia: a multisite mega-analysis of 983 patients and 1349 healthy controls. Mol Psychiatry 2017, 23: 1512.

    Article  Google Scholar 

  5. Ishida T, Donishi T, Iwatani J, Yamada S, Takahashi S, Ukai S, et al. Elucidating the aberrant brain regions in bipolar disorder using T1-weighted/T2-weighted magnetic resonance ratio images. Psychiatry Res 2017, 263: 76–84.

    Article  Google Scholar 

  6. Noordermeer SDS, Luman M, Greven CU, Veroude K, Faraone SV, Hartman CA, et al. Structural brain abnormalities of attention-deficit/hyperactivity disorder with oppositional defiant disorder. Biol Psychiatry 2017, 82: 642–650.

    Article  Google Scholar 

  7. Marín O. Developmental timing and critical windows for the treatment of psychiatric disorders. Nat Med 2016, 22: 1229.

    Article  Google Scholar 

  8. Johnson MB, Kawasawa YI, Mason CE, Krsnik Ž, Coppola G, Bogdanović D, et al. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron 2009, 62: 494–509.

    Article  CAS  Google Scholar 

  9. Gomes FV, Rincón-Cortés M, Grace AA. Adolescence as a period of vulnerability and intervention in schizophrenia: Insights from the MAM model. Neurosci Biobehav Rev 2016, 70: 260–270.

    Article  Google Scholar 

  10. Laidi C, d’Albis MA, Wessa M, Linke J, Phillips ML, Delavest M, et al. Cerebellar volume in schizophrenia and bipolar I disorder with and without psychotic features. Acta Psychiatr Scand 2015, 131: 223–233.

    Article  CAS  Google Scholar 

  11. Farzan F, Garcia Dominguez L, Semeralul MO, Radhu N, Daskalakis ZJ, Richter MA, et al. Evidence for inhibitory deficits in the prefrontal cortex in schizophrenia. Brain 2014, 138: 483–497.

    PubMed  PubMed Central  Google Scholar 

  12. Nowrouzi B, McIntyre RS, MacQueen G, Kennedy SH, Kennedy JL, Ravindran A, et al. Admixture analysis of age at onset in first episode bipolar disorder. J Affect Disord 2016, 201: 88–94.

    Article  Google Scholar 

  13. Blumberg HP, Stern E, Ricketts S, Martinez D, de Asis J, White T, et al. Rostral and orbital prefrontal cortex dysfunction in the manic state of bipolar disorder. Am J Psychiatry 1999, 156: 1986–1988.

    CAS  PubMed  Google Scholar 

  14. Pacifico R, Davis RL. Transcriptome sequencing implicates dorsal striatum-specific gene network, immune response and energy metabolism pathways in bipolar disorder. Mol Psychiatry 2016, 22: 441.

    Article  Google Scholar 

  15. MacMullen CM, Vick K, Pacifico R, Fallahi-Sichani M, Davis RL. Novel, primate-specific PDE10A isoform highlights gene expression complexity in human striatum with implications on the molecular pathology of bipolar disorder. Transl Psychiatry 2016, 6: e742.

    Article  CAS  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Scientific Foundation of China (81673112), the Key Projects of International Cooperation among Governments in Scientific and Technological Innovation (2016YFE0119100), the Natural Science Basic Research Plan in Shaanxi Province of China (2017JZ024), and the Fundamental Research Funds for the Central Universities.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Feng Zhang.

Ethics declarations

Conflict of interest

The authors claim that there are no conflicts of interest.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (PDF 150 kb)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Qi, X., Wu, C., Du, Y. et al. Comparing GWAS and Brain Structure-Specific Gene Expression Profiles Identifies Psychiatric Disorder-Related Brain Structures at Different Developmental Stages. Neurosci. Bull. 36, 1046–1050 (2020). https://doi.org/10.1007/s12264-020-00521-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12264-020-00521-7

Navigation