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Glucose-sensing properties of citrate-functionalized maghemite nanoparticle–modified indium tin oxide electrodes

Published online by Cambridge University Press:  29 May 2020

Noorhashimah Mohamad Nor ,
Khairunisak Abdul Razak  and
Zainovia Lockman
Noorhashimah Mohamad Nor
Affiliation:
School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang 14300, Malaysia
Khairunisak Abdul Razak*
Affiliation:
School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang 14300, Malaysia; and NanoBiotechnology Research and Innovation (NanoBRI), INFORMM, Universiti Sains Malaysia, Pulau Pinang 11800, Malaysia
Zainovia Lockman
Affiliation:
School of Materials and Mineral Resources Engineering, Universiti Sains Malaysia, Nibong Tebal, Pulau Pinang 14300, Malaysia
*
a)Address all correspondence to this author. e-mail: khairunisak@usm.my
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Abstract

Iron oxide nanoparticles presenting colloidal stability in water were prepared through precipitation and then surface-functionalized with varying citric acid (CA) concentrations (0.10, 0.25, 0.50, and 0.70 g/mL). CA introduced functionality and minimized agglomeration. Iron oxide nanoparticles with colloidal stability in water at physiological pH were obtained after functionalization with 0.25–0.70 g/mL CA, whereas iron oxide nanoparticles without stability in water were obtained after functionalization with 0.10 g/mL CA. An electrode for glucose detection was fabricated by self-assembling colloidal-stable γ-Fe2O3 NP–CA in water on indium tin oxide (ITO) glass, followed by a glucose oxidase (GOx) and Nafion layer. The optimal functionalization of the γ-Fe2O3 NPs was obtained at a CA concentration of 0.25 g/mL. The electrochemical properties and electrocatalytic behavior of the modified electrode designated as Nafion/GOx/γ-Fe2O3 NP–0.25 CA/ITO were then evaluated. The electrode showed high sensitivity for glucose detection of 995.57 and 5.81 µA/(mM cm2) within the linear ranges of 0.1–5.0 µM and 5.0 µM–20.0 mM, respectively. The modified electrode also demonstrated a low limit of detection, good repeatability of 2.5% (n = 10), and sufficient reproducibility of 3.2% (n = 5).

Keywords

colloidbiomimetic (assembly)sensor
Type
Article
Information
Journal of Materials Research , Volume 35 , Issue 10 , 28 May 2020 , pp. 1279 - 1289
Copyright
Copyright © Materials Research Society 2020

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