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HOST CELL RESISTANCE

Cholesterol in quarantine

Nature Immunology volume 21, pages 716–717 (2020)Cite this article

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Host cell cholesterol is often exploited by pathogens for entry and egress. Two new studies elucidate a new interferon-inducible mechanism by which cells limit plasma membrane cholesterol to promote antibacterial defense.

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Fig. 1: 25-HC blocks bacterial cell-to-cell spread and toxin activity via sequestration of plasma membrane cholesterol.

References

  1. Zhou, Q. D. et al. Nat. Immunol. https://doi.org/10.1038/s41590-020-0695-4 (2020).

  2. Abrams, M. E. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-020-0701-5 (2020).

  3. Brown, M. S., Radhakrishnan, A. & Goldstein, J. L. Annu. Rev. Biochem. 87, 783–807 (2018).

    Article  CAS  Google Scholar 

  4. Das, A., Brown, M. S., Anderson, D. D., Goldstein, J. L. & Radhakrishnan, A. T. Elife 3, 02882 (2014).

    Article  Google Scholar 

  5. Blanc, M. et al. PLoS Biol. 9, e1000598 (2011).

    Article  CAS  Google Scholar 

  6. Bauman, D. R. et al. Proc. Natl Acad. Sci. USA 106, 16764–16769 (2009).

    CAS  Google Scholar 

  7. Reboldi, A. et al. Science 345, 679–684 (2014).

    Article  CAS  Google Scholar 

  8. Gold, E. S. et al. Proc. Natl Acad. Sci. USA 111, 10666–10671 (2014).

    Article  CAS  Google Scholar 

  9. Dang, E. V., McDonald, J. G., Russell, D. W. & Cyster, J. G. Cell 171, 1057–1071.e11 (2017).

    Article  CAS  Google Scholar 

  10. Liu, S.-Y. et al. Immunity 38, 92–105 (2013).

    Article  Google Scholar 

  11. Blanc, M. et al. Immunity 38, 106–118 (2013).

    Article  CAS  Google Scholar 

  12. Liu, S.-Y., Sanchez, D. J., Aliyari, R., Lu, S. & Cheng, G. Proc. Natl Acad. Sci. USA 109, 4239–4244 (2012).

    Article  CAS  Google Scholar 

  13. Glomski, I. J., Gedde, M. M., Tsang, A. W., Swanson, J. A. & Portnoy, D. A. J. Cell Biol. 156, 1029–1038 (2002).

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA

    Eric V. Dang & Hiten D. Madhani

  2. Chan-Zuckerberg Biohub, San Francisco, CA, USA

    Hiten D. Madhani

  3. Howard Hughes Medical Institute and Department of Molecular and Cell Biology, University of California, Berkeley, CA, USA

    Russell E. Vance

Authors
  1. Eric V. Dang
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  2. Hiten D. Madhani
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  3. Russell E. Vance
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Correspondence to Russell E. Vance.

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Dang, E.V., Madhani, H.D. & Vance, R.E. Cholesterol in quarantine. Nat Immunol 21, 716–717 (2020). https://doi.org/10.1038/s41590-020-0712-7

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