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Phylogenetic Analysis of Clinically Relevant Fusarium Species in Iran

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Abstract

Fungi of the genus Fusarium are well known as major plant pathogens but also cause a broad spectrum of human infections. Sixty-three clinical isolates, collected during 2014–2017, were identified using a part of the TEF1 gene as barcoding marker. Fusarium fujikuroi species complex (FFSC, n = 41, 65%) showed to be the dominant etiological agent, followed by F. solani species complex (FSSC, n = 14, 22%) and F. oxysporum species complex (FOSC, n = 7, 11%). There was one strain belonging to F. lateritium species complex (FLSC, n = 1, 1.5%). For final identification, a phylogenetic tree was constructed including the type strains of each species complex. Most cases of fusariosis were due to nail infection (n = 38, 60.3%), followed by keratitis (n = 22, 34%). Fusarium infections are difficult to be treated due to their intrinsic resistance to different azoles; however, accurate and fast identification of etiological agents may enhance management of the infection. We present the first phylogenetic study on clinical Fusarium spp. from Iran.

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Acknowledgements

This work was supported by the National Institute for Medical Research Development of Iran (Grant No. IR.NIMAD.REC.971086).

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Author notes

  1. Mohammad Javad Najafzadeh and Somayeh Dolatabadi have contributed equally to this work.

Authors and Affiliations

  1. Department of Parasitology and Mycology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Javad Najafzadeh & Mahmoud Karimizadeh Esfahani

  2. Cancer Molecular Pathology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Mohammad Javad Najafzadeh

  3. Faculty of Engineering, Sabzevar University of New Technology, Sabzevar, Iran

    Somayeh Dolatabadi

  4. Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

    Sybren de Hoog & Abdullah M. S. Al-Hatmi

  5. Foundation Atlas of Clinical Fungi, Hilversum, The Netherlands

    Sybren de Hoog & Abdullah M. S. Al-Hatmi

  6. Invasive Fungi Research Center (IFRC), School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

    Iman Haghani, Seyed Reza Aghili & Mahdi Abastabar

  7. Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Roshanak Daei Ghazvini

  8. Department of Medical Mycology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Ali Rezaei-Matehkolaei

  9. Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

    Ali Rezaei-Matehkolaei

  10. Ministry of Health, Directorate General of Health Services, Ibri, Oman

    Abdullah M. S. Al-Hatmi

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  1. Mohammad Javad Najafzadeh
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Correspondence to Mahdi Abastabar or Abdullah M. S. Al-Hatmi.

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The study protocol was approved by the Ethics Committee of the National Institute for Medical Research Development (NIMAD) of Iran (IR.NIMAD.REC. 1397, 231).

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Najafzadeh, M.J., Dolatabadi, S., de Hoog, S. et al. Phylogenetic Analysis of Clinically Relevant Fusarium Species in Iran. Mycopathologia 185, 515–525 (2020). https://doi.org/10.1007/s11046-020-00460-x

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