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Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice

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Abstract

Depression is an emotional disorder that causes mental and physical changes, and has limited pharmacotherapy. Tannic acid (TA) is a polyphenol with previously described antioxidant and neuroprotective properties. The aim of this study was to evaluate the effects of TA on lipopolysaccharide (LPS)-induced depressive-like behavior, as well as oxidative stress parameters and TNF-α levels in the brains of mice. Animals were pretreated once daily, with TA (30 or 60 mg/kg), fluoxetine (20 mg/kg) or vehicle for 7 days. On the 7th day, the animals received a single injection of LPS (830 μg/kg). After 24 h, open field, forced swimming, tail suspension, and splash tests were conducted. The endotoxin induced depressive-like behavior in these mice and this was attenuated by TA. In the cerebral cortex, hippocampus, and striatum, LPS increased lipid peroxidation and reactive oxygen species production, and this was also prevented by TA administration. TA treatment also prevented a decrease in catalase activity within the striatum. Further, LPS administration caused increased levels of TNF-α in all brain structures, and this was prevented in the cortex by TA treatment. In conclusion, TA shows many neuroprotective properties, with demonstrated antioxidant, anti-inflammatory and antidepressant effects in this animal model of acute depressive-like behavior. Therefore, this compound could provide an alternative therapeutic approach for the treatment of depression.

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Acknowledgements

The Brazilian research funding agencies Fundação de Amparo à pesquisa do Estado do Rio Grande do Sul, Conselho Nacional de Desenvolvimento Científico e Tecnológico and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Finance code 001) supported this study.

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Authors and Affiliations

  1. Programa de Pós-Graduação Em Bioquímica E Bioprospecção - Laboratório de Biomarcadores, Centro de Ciências Químicas, Farmacêuticas E de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, CEP: 96010-900, Brazil

    Karina Pereira Luduvico, Alana Seixas de Farias, Natália Pontes Bona & Francieli Moro Stefanello

  2. Programa de Pós-Graduação Em Bioquímica E Bioprospecção - Laboratório de Neuroquímica, Inflamação E Câncer, Centro de Ciências Químicas, Farmacêuticas E de Alimentos, Universidade Federal de Pelotas, Campus Universitário s/n, Pelotas, RS, Brazil

    Luiza Spohr, Mayara Sandrielly Pereira Soares, Fernanda Cardoso Teixeira, Nathalia Stark Pedra & Roselia Maria Spanevello

  3. Biotério Central, Universidade Federal de Pelotas, Campus Universitário S/N, Pelotas, RS, Brazil

    Anelize de Oliveira Campello Felix

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  1. Karina Pereira Luduvico
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  2. Luiza Spohr
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Correspondence to Karina Pereira Luduvico or Francieli Moro Stefanello.

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Luduvico, K.P., Spohr, L., Soares, M.S.P. et al. Antidepressant Effect and Modulation of the Redox System Mediated by Tannic Acid on Lipopolysaccharide-Induced Depressive and Inflammatory Changes in Mice. Neurochem Res 45, 2032–2043 (2020). https://doi.org/10.1007/s11064-020-03064-5

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