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New Arteannuin B Derivatives and Their Cytotoxic Activity

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Chemistry of Natural Compounds Aims and scope

Previously unknown conjugates of the natural sesquiterpene lactone arteannuin B, which was isolated from Artemisia annua, were synthesized via Michael reactions with pharmacophoric amines and tested in vitro for cytotoxic activity. The compounds were shown to exhibit antiproliferative properties for various tumor cell lines. The most active derivatives had IC50 values of 8–36 μM, which exceeded that of starting arteannuin B. Practically all obtained conjugates were found to modulate glycolysis in MCF7 tumor cells. The lead compound was the conjugate with 3-ethoxycarbonylpiperidine, which could be considered a platform for developing antitumor drugs.

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Acknowledgment

The biological part of the work was financially supported by RFBR Grant No. 18-33-20209; synthesis of compounds, under State Task 0090_2019_0006.

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Authors and Affiliations

  1. Institute of Physiologically Active Compounds, Russian Academy of Sciences, 1 Severnyi Proezd, Chernogolovka, Moscow Oblast, 142432, Russia

    S. G. Klochkov, M. E. Neganova, S. A. Pukhov, S. V. Afanas’eva, Yu. R. Aleksandrova & E. Yu. Yandulova

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  1. S. G. Klochkov
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  2. M. E. Neganova
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  3. S. A. Pukhov
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  4. S. V. Afanas’eva
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  5. Yu. R. Aleksandrova
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  6. E. Yu. Yandulova
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Correspondence to S. G. Klochkov.

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Translated from Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 385–391.

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Klochkov, S.G., Neganova, M.E., Pukhov, S.A. et al. New Arteannuin B Derivatives and Their Cytotoxic Activity. Chem Nat Compd 56, 445–451 (2020). https://doi.org/10.1007/s10600-020-03059-2

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  • DOI: https://doi.org/10.1007/s10600-020-03059-2

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