Two new isoquinoline alkaloids, 3-hydroxy-1-(7-hydroxy-6-methylisoquinolin-1-yl)propan-1-one (1) and 3-hydroxy-1-(7-methoxy-6-methylisoquinolin-1-yl)propan-1-one (2) were isolated from the whole plants of Thalictrum glandulosissimum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The two compounds showed weak anti-TMV activity with inhibition rates of 28.9 and 32.6%. These rates are close to that of positive control.
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This project was supported by the National Natural Science Foundation of China (No. 21762050), the Applied Basic Research Foundation of Yunnan Province (No. 2017FB014), and the Foundation of Yunnan Innovative Research Team.
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Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 430–432.
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Hu, QF., Liao, LM., Huang, HT. et al. Two New Isoquinoline Alkaloids from Whole Plants of Thalictrum glandulosissimum and their Anti-TMV Activity. Chem Nat Compd 56, 500–503 (2020). https://doi.org/10.1007/s10600-020-03071-6
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DOI: https://doi.org/10.1007/s10600-020-03071-6