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Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity

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Chemistry of Natural Compounds Aims and scope

Two new (1 and 2), together with two known (3 and 4), isoquinoline alkaloids were isolated from the whole plants of Thalictrum cirrhosum. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1–4 were tested for their antirotavirus activity. The results revealed that compounds 2 exhibited high antirotavirus activity with a therapeutic index (TI) value of 19.3. This value is close to that of positive control (TI value 20.4). Compounds 1, 3, and 4 also exhibited potent antirotavirus activity with TI value above 10.

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Acknowledgment

This project was supported by the National Natural Science Foundation of China (No. 21762050), the Applied Basic Research Foundation of Yunnan Province (No. 2017FB014), and the Foundation of Yunnan Innovative Research Team.

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Authors and Affiliations

  1. Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, 650031, Kunming, P. R. China

    Dian Luo, Na Lv, Li-Jun Zhu, Ling-Min Liao, Min Zhou, Guang-Yu Yang & Qiu-Fen Hu

  2. Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industrial Co., Ltd., 650231, Kunming, P. R. China

    Dian Luo, Yong Xu, Jin Wang, Wei-Song Kong, Hai-Tao Huang, Guang-Yu Yang, Qiu-Fen Hu & Xiao-Xi Si

Authors
  1. Dian Luo
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  2. Na Lv
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  3. Li-Jun Zhu
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  4. Ling-Min Liao
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  5. Yong Xu
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  6. Jin Wang
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  9. Min Zhou
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  10. Guang-Yu Yang
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  11. Qiu-Fen Hu
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  12. Xiao-Xi Si
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Corresponding authors

Correspondence to Qiu-Fen Hu or Xiao-Xi Si.

Additional information

Published in Khimiya Prirodnykh Soedinenii, No. 3, May–June, 2020, pp. 433–436.

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Luo, D., Lv, N., Zhu, LJ. et al. Isoquinoline Alkaloids from Whole Plants of Thalictrum cirrhosum and Their Antirotavirus Activity. Chem Nat Compd 56, 504–508 (2020). https://doi.org/10.1007/s10600-020-03072-5

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  • DOI: https://doi.org/10.1007/s10600-020-03072-5

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