Skip to main content

Advertisement

SpringerLink
Log in

Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma

  • Review
  • Published:
Cellular Oncology Aims and scope Submit manuscript

Abstract

Background

Oral squamous cell carcinoma (OSCC) has the highest mortality rate among all head and neck cancers and a relatively low five-year survival rate. Generally, the development of an oral mucosal malignancy represents a multistep process beginning with normal oral mucosa epithelium and culminating in OSCC after transitioning through intermediary oral premalignant disorders (OPMDs), during which dysplasia is often observed. Noncoding RNAs (ncRNAs) are RNAs that are not translated into proteins, but still can participate in regulating neoplastic cell behavior. Recently, data have emerged on the role of ncRNAs in the progression of oral mucosal malignant diseases, but the exact mechanisms through which ncRNAs are involved remain to be elucidated.

Conclusions

Knowledge on ncRNAs has added an extra layer of complexity to our understanding of the malignant progression of oral mucosal diseases. The identification of ncRNAs in multiple body fluids as biomarkers may provide new diagnostic options that can be used for the diagnosis and prognosis of OPMDs and OSCC, respectively. Despite overall advances that have been made in cancer treatment, the treatment options for OPMDs and OSCC are still limited. Several studies have shown that ncRNA-based treatment regimens may hold promise as alternative methods for treating OPMDs and OSCC. The use of ncRNAs as therapeutic agents, including miR-155, miR-34 and lncRNA HOTAIR, appear promising.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2.
Fig. 3.

Similar content being viewed by others

Data Availability

The datasets generated and analyzed during the current study are available in the PubMed repository, www.ncbi.nlm.nih.gov/pubmed.

References

  1. F. Bray, J. Ferlay, I. Soerjomataram, R.L. Siegel, L.A. Torre, A. Jemal, Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 68, 394–424 (2018)

    PubMed  Google Scholar 

  2. S.R. Moore, N.W. Johnson, A.M. Pierce, D.F. Wilson, The epidemiology of mouth cancer: A review of global incidence. Oral Dis. 6, 65–74 (2000)

    Article  CAS  PubMed  Google Scholar 

  3. A.W. Joseph, G. D'Souza, Epidemiology of human papillomavirus-related head and neck cancer. Otolaryngol. Clin. N. Am. 45, 739–764 (2012)

    Article  Google Scholar 

  4. L.L. Feller, R.R. Khammissa, B.B. Kramer, J.J. Lemmer, Oral squamous cell carcinoma in relation to field precancerisation: Pathobiology. Cancer Cell Int. 13, 31 (2013)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. C.P. Gan, K.K. Sam, P.S. Yee, N.S. Zainal, B.K.B. Lee, Z.A.A. Rahman, V. Patel, A.C. Tan, R.B. Zain, S.C. Cheong, IFITM3 knockdown reduces the expression of CCND1 and CDK4 and suppresses the growth of oral squamous cell carcinoma cells. Cell. Oncol. 42, 477–490 (2019)

    Article  CAS  Google Scholar 

  6. U.U. Malik, S. Zarina, S.R. Pennington, Oral squamous cell carcinoma: Key clinical questions, biomarker discovery, and the role of proteomics. Arch. Oral Biol. 63, 53–65 (2016)

    Article  CAS  PubMed  Google Scholar 

  7. S. Warnakulasuriya, N.W. Johnson, I. van der Waal, Nomenclature and classification of potentially malignant disorders of the oral mucosa. J. Oral Pathol. Med. 36, 575–580 (2007)

    Article  CAS  PubMed  Google Scholar 

  8. L. Ben, Slama, Potentially malignant disorders of the oral mucosa: Terminology and classification. Rev. Stomatol. Chir. Maxillofac. 111, 208–212 (2010)

  9. J.S. Yu, Y.T. Chen, W.F. Chiang, Y.C. Hsiao, L.J. Chu, L.C. See, C.S. Wu, H.T. Tu, H.W. Chen, C.C. Chen, W.C. Liao, Y.T. Chang, C.C. Wu, C.Y. Lin, S.Y. Liu, S.T. Chiou, S.L. Chia, K.P. Chang, C.Y. Chien, S.W. Chang, C.J. Chang, J.D. Young, C.C. Pao, Y.S. Chang, L.H. Hartwell, Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan. Proc. Natl. Acad. Sci. U. S. A. 113, 11549–11554 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. S. Liu, J. Liu, J. Wang, J. Cheng, X. Zeng, N. Ji, J. Li, Q. Chen, RACK1 is an organ-specific prognostic predictor in OSCC. Oral Oncol. 76, 22–26 (2018)

    Article  CAS  PubMed  Google Scholar 

  11. J. Li, X. Feng, C. Sun, X. Zeng, L. Xie, H. Xu, T. Li, R. Wang, X. Xu, X. Zhou, M. Zhou, Y. Zhou, H. Dan, Z. Wang, N. Ji, P. Deng, G. Liao, N. Geng, Y. Wang, D. Zhang, Y. Lin, L. Ye, X. Liang, L. Li, G. Luo, L. Jiang, Z. Wang, Q. Chen, Associations between proteasomal activator PA28gamma and outcome of oral squamous cell carcinoma: Evidence from cohort studies and functional analyses. EBioMedicine 2, 851–858 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  12. D.R. Zerbino, P. Achuthan, W. Akanni, M.R. Amode, D. Barrell, J. Bhai, K. Billis, C. Cummins, A. Gall, C.G. Giron, L. Gil, L. Gordon, L. Haggerty, E. Haskell, T. Hourlier, O.G. Izuogu, S.H. Janacek, T. Juettemann, J.K. To, M.R. Laird, I. Lavidas, Z. Liu, J.E. Loveland, T. Maurel, W. McLaren, B. Moore, J. Mudge, D.N. Murphy, V. Newman, M. Nuhn, D. Ogeh, C.K. Ong, A. Parker, M. Patricio, H.S. Riat, H. Schuilenburg, D. Sheppard, H. Sparrow, K. Taylor, A. Thormann, A. Vullo, B. Walts, A. Zadissa, A. Frankish, S.E. Hunt, M. Kostadima, N. Langridge, F.J. Martin, M. Muffato, E. Perry, M. Ruffier, D.M. Staines, S.J. Trevanion, B.L. Aken, F. Cunningham, A. Yates, P. Flicek, Ensembl 2018. Nucleic Acids Res. 46, D754–D761 (2018)

    Article  CAS  PubMed  Google Scholar 

  13. M. Gorenchtein, C.F. Poh, R. Saini, C. Garnis, MicroRNAs in an oral cancer context - from basic biology to clinical utility. J. Dent. Res. 91, 440–446 (2012)

    Article  CAS  PubMed  Google Scholar 

  14. F. Kopp, J.T. Mendell, Functional classification and experimental dissection of long noncoding RNAs. Cell 172, 393–407 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. K. Lei, H. Bai, Z. Wei, C. Xie, J. Wang, J. Li, Q. Chen, The mechanism and function of circular RNAs in human diseases. Exp. Cell Res. 368, 147–158 (2018)

    Article  CAS  PubMed  Google Scholar 

  16. T. Yap, C. Seers, K. Koo, L. Cheng, L.J. Vella, A.F. Hill, E. Reynolds, A. Nastri, N. Cirillo, M. McCullough, Non-invasive screening of a microRNA-based dysregulation signature in oral cancer and oral potentially malignant disorders. Oral Oncol. 96, 113–120 (2019)

    Article  CAS  PubMed  Google Scholar 

  17. A. Villa, S. Sonis, Oral leukoplakia remains a challenging condition. Oral Dis. 24, 179–183 (2018)

    Article  CAS  PubMed  Google Scholar 

  18. A. Maimaiti, K. Abudoukeremu, L. Tie, Y. Pan, X. Li, MicroRNA expression profiling and functional annotation analysis of their targets associated with the malignant transformation of oral leukoplakia. Gene 558, 271–277 (2015)

    Article  CAS  PubMed  Google Scholar 

  19. Y. Yang, Y.X. Li, X. Yang, L. Jiang, Z.J. Zhou, Y.Q. Zhu, Progress risk assessment of oral premalignant lesions with saliva miRNA analysis. BMC Cancer 13, 129 (2013)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. N.K. Cervigne, P.P. Reis, J. Machado, B. Sadikovic, G. Bradley, N.N. Galloni, M. Pintilie, I. Jurisica, B. Perez-Ordonez, R. Gilbert, P. Gullane, J. Irish, S. Kamel-Reid, Identification of a microRNA signature associated with progression of leukoplakia to oral carcinoma. Hum. Mol. Genet. 18, 4818–4829 (2009)

    Article  CAS  PubMed  Google Scholar 

  21. G. Lodi, M. Carrozzo, S. Furness, K. Thongprasom, Interventions for treating oral lichen planus: A systematic review. Br. J. Dermatol. 166, 938–947 (2012)

    Article  CAS  PubMed  Google Scholar 

  22. M. Mehdipour, M. Shahidi, S. Manifar, S. Jafari, F.M. Abbas, M. Barati, H. Mortazavi, M. Shirkhoda, A. Farzanegan, Z.E. Rankohi, Diagnostic and prognostic relevance of salivary microRNA-21,-125a,-31 and-200a levels in patients with oral lichen planus - a short report. Cell. Oncol. 41, 329–334 (2018)

    Article  CAS  Google Scholar 

  23. L. Wang, W. Wu, J. Chen, Y. Li, M. Xu, Y. Cai, MicroRNA microarray-based identification of involvement of miR-155 and miR-19a in development of Oral lichen Planus (OLP) by modulating Th1/Th2 balance via targeting eNOS and toll-like receptor 2 (TLR2). Med. Sci. Monit. 24, 3591–3603 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. J.Y. Hu, J. Zhang, J.Z. Ma, X.Y. Liang, G.Y. Chen, R. Lu, G.F. Du, G. Zhou, MicroRNA-155-IFN-gamma feedback loop in CD4(+)T cells of erosive type Oral lichen Planus. Sci. Rep. 5, 16935 (2015)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. J. Wang, X. Zhai, J. Guo, Y. Li, Y. Yang, L. Wang, L. Yang, F. Liu, Long non-coding RNA DQ786243 modulates the induction and function of CD4(+) Treg cells through Foxp3-miR-146a-NF-kappaB axis: Implications for alleviating oral lichen planus. Int. Immunopharmacol. 75, 105761 (2019)

    Article  CAS  PubMed  Google Scholar 

  26. J. Wang, H. Luo, Y. Xiao and L. Wang, miR-125b inhibits keratinocyte proliferation and promotes keratinocyte apoptosis in oral lichen planus by targeting MMP-2 expression through PI3K/Akt/mTOR pathway. Biomed. Pharmacother. 80, 373–380 (2016)

  27. J. Wang, L. Yang, L. Wang, Y. Yang, Y. Wang, Forkhead box p3 controls progression of oral lichen planus by regulating microRNA-146a. J. Cell. Biochem. 119, 8862–8871 (2018)

    Article  CAS  PubMed  Google Scholar 

  28. J. Chen, Y. Wang, G. Du, W. Zhang, T. Cao, L. Shi, Y. Wang, J. Mi and G. Tang, Down-regulation of miRNA-27b-3p suppresses keratinocytes apoptosis in oral lichen planus. J. Cell. Mol. Med. 23, 4326–4337 (2019)

  29. Q. Yang, H. Sun, X. Wang, X. Yu, J. Zhang, B. Guo, S. Hexige, Metabolic changes during malignant transformation in primary cells of oral lichen planus: Succinate accumulation and tumour suppression. J. Cell. Mol. Med. 24, 1179–1188 (2020)

  30. N.A. Ghallab, R.F. Kasem, S.F.A. El-Ghani, O.G. Shaker, Gene expression of miRNA-138 and cyclin D1 in oral lichen planus. Clin. Oral Investig. 21, 2481–2491 (2017)

    Article  PubMed  Google Scholar 

  31. H. Zheng, S. Li, Reduced miRNA214 expression in oral mucosa contributes to the pathogenesis of oral lichen planus by targeting CD44. Mol. Med. Rep. 17, 1919–1925 (2018)

    CAS  PubMed  Google Scholar 

  32. J. Chen, G. Du, Y. Chang, Y. Wang, L. Shi, J. Mi, G. Tang, Downregulated miR-27b promotes keratinocyte proliferation by targeting PLK2 in oral lichen planus. J. Oral Pathol. Med. 48, 326–334 (2019)

    Article  CAS  PubMed  Google Scholar 

  33. J. Chen, Y. Wang, G. Du, W. Zhang, T. Cao, L. Shi, Y. Wang, J. Mi, G. Tang, Down-regulation of miRNA-27b-3p suppresses keratinocytes apoptosis in oral lichen planus. J. Cell. Mol. Med. 23, 4326–4337 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. D.D. Stasio, L. Mosca, A. Lucchese, D.D. Cave, H. Kawasaki, A. Lombardi, M. Porcelli, M. Caraglia, Salivary mir-27b expression in oral lichen planus patients: A series of cases and a narrative review of litterature. Curr. Top. Med. Chem. 19, 2816–2823 (2019)

  35. W.Y. Zhang, W. Liu, Y.M. Zhou, X.M. Shen, Y.F. Wang, G.Y. Tang, Altered microRNA expression profile with miR-27b down-regulation correlated with disease activity of oral lichen planus. Oral Dis. 18, 265–270 (2012)

    Article  CAS  PubMed  Google Scholar 

  36. W. Shi, J. Yang, S. Li, X. Shan, X. Liu, H. Hua, C. Zhao, Z. Feng, Z. Cai, L. Zhang, D. Zhou, Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget 6, 40172–40185 (2015)

    Article  PubMed  PubMed Central  Google Scholar 

  37. Z. Shen, G. Du, Z. Zhou, W. Liu, L. Shi, H. Xu, Aberrant expression of interleukin-22 and its targeting microRNAs in oral lichen planus: A preliminary study. J. Oral Pathol. Med. 45, 523–527 (2016)

    Article  CAS  PubMed  Google Scholar 

  38. J. Dang, Y.Q. Bian, J.Y. Sun, F. Chen, G.Y. Dong, Q. Liu, X.W. Wang, J. Kjems, S. Gao, Q.T. Wang, MicroRNA-137 promoter methylation in oral lichen planus and oral squamous cell carcinoma. J. Oral Pathol. Med. 42, 315–321 (2013)

    Article  CAS  PubMed  Google Scholar 

  39. J.G. Yang, Y.R. Sun, G.Y. Chen, X.Y. Liang, J. Zhang, G. Zhou, Different expression of MicroRNA-146a in peripheral blood CD4(+) T cells and lesions of Oral lichen Planus. Inflammation 39, 860–866 (2016)

    Article  CAS  PubMed  Google Scholar 

  40. K. Danielsson, Y.B. Wahlin, X. Gu, L. Boldrup, K. Nylander, Altered expression of miR-21, miR-125b, and miR-203 indicates a role for these microRNAs in oral lichen planus. J. Oral Pathol. Med. 41, 90–95 (2012)

    Article  CAS  PubMed  Google Scholar 

  41. M. Mehdipour, M. Shahidi, S. Manifar, S. Jafari, F. Mashhadi Abbas, M. Barati, H. Mortazavi, M. Shirkhoda, A. Farzanegan, Z. Elmi Rankohi, Diagnostic and prognostic relevance of salivary microRNA-21, −125a, −31 and -200a levels in patients with oral lichen planus - a short report. Cell. Oncol. 41, 329–334 (2018)

  42. E. Chattopadhyay, R. Singh, A. Ray, R. Roy, N. De Sarkar, R.R. Paul, M. Pal, R. Aich, B. Roy, Expression deregulation of mir31 and CXCL12 in two types of oral precancers and cancer: Importance in progression of precancer and cancer. Sci. Rep. 6, 32735 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  43. L. Wang, W. Wu, J. Chen, Y. Li, M. Xu and Y. Cai, miR122 and miR199 synergistically promote autophagy in oral lichen planus by targeting the Akt/mTOR pathway, Int. J. Mol. Med. 43, 1373–1381 (2019)

  44. I. van der Waal, Potentially malignant disorders of the oral and oropharyngeal mucosa; terminology, classification and present concepts of management. Oral Oncol. 45, 317–323 (2009)

    Article  PubMed  Google Scholar 

  45. S.S. Hsue, W.C. Wang, C.H. Chen, C.C. Lin, Y.K. Chen, L.M. Lin, Malignant transformation in 1458 patients with potentially malignant oral mucosal disorders: A follow-up study based in a Taiwanese hospital. J. Oral Pathol. Med. 36, 25–29 (2007)

    Article  PubMed  Google Scholar 

  46. D. Chickooree, K. Zhu, V. Ram, H.J. Wu, Z.J. He, S. Zhang, A preliminary microarray assay of the miRNA expression signatures in buccal mucosa of oral submucous fibrosis patients. J. Oral Pathol. Med. 45, 691–697 (2016)

    Article  CAS  PubMed  Google Scholar 

  47. Y.Y. Hou, J.H. Lee, H.C. Chen, C.M. Yang, S.J. Huang, H.H. Liou, C.C. Chi, K.W. Tsai, L.P. Ger, The association between miR-499a polymorphism and oral squamous cell carcinoma progression. Oral Dis. 21, 195–206 (2015)

    Article  CAS  PubMed  Google Scholar 

  48. Y.W. Liao, C.C. Yu, P.L. Hsieh, Y.C. Chang, miR-200b ameliorates myofibroblast transdifferentiation in precancerous oral submucous fibrosis through targeting ZEB2. J. Cell. Mol. Med. 22, 4130–4138 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  49. S. Zhou, Y. Zhu, Z. He, D. Zhang, F. Guo, X. Jian, C. Zhang, Long non-coding RNA expression profile associated with malignant progression of Oral submucous fibrosis. J. Oncol. 2019, 6835176 (2019)

    PubMed  PubMed Central  Google Scholar 

  50. C.Y. Fang, C.C. Yu, Y.W. Liao, P.L. Hsieh, M.Y. Lu, K.C. Lin, C.Z. Wu, L.L. Tsai, LncRNA LINC00974 activates TGF-beta/Smad signaling to promote oral fibrogenesis. J. Oral Pathol. Med. 48, 151–158 (2019)

    Article  CAS  PubMed  Google Scholar 

  51. C.Y. Lin, Y.W. Liao, P.L. Hsieh, M.Y. Lu, C.Y. Peng, P.M. Chu, H.W. Yang, Y.F. Huang, C.C. Yu, C.H. Yu, LncRNA GAS5-AS1 Inhibits Myofibroblasts Activities in Oral Submucous Fibrosis. J. Formos. Med. Assoc. 117, 727–733 (2018)

    Article  CAS  PubMed  Google Scholar 

  52. B. Zhang, Y. Li, D. Hou, Q. Shi, S. Yang, Q. Li, MicroRNA-375 inhibits growth and enhances Radiosensitivity in Oral squamous cell carcinoma by targeting insulin like growth factor 1 receptor. Cell. Physiol. Biochem. 42, 2105–2117 (2017)

    Article  CAS  PubMed  Google Scholar 

  53. R. Xu, G. Zeng, J. Gao, Y. Ren, Z. Zhang, Q. Zhang, J. Zhao, H. Tao, D. Li, miR-138 suppresses the proliferation of oral squamous cell carcinoma cells by targeting Yes-associated protein 1. Oncol. Rep. 34, 2171–2178 (2015)

    Article  CAS  PubMed  Google Scholar 

  54. C. Li, J. Ye, Z. Zhang, Z. Gong, Z. Lin, M. Ding, Long non-coding RNA RBM5-AS1 promotes the aggressive behaviors of oral squamous cell carcinoma by regulation of miR-1285-3p/YAP1 axis. Biomed. Pharmacother. 123, 109723 (2019)

    Article  PubMed  CAS  Google Scholar 

  55. W. Su, Y. Wang, F. Wang, B. Zhang, H. Zhang, Y. Shen, H. Yang, Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma. J. Cell. Physiol. 234, 15156–15166 (2019)

    Article  CAS  PubMed Central  Google Scholar 

  56. C. Liu, Z. Wang, Y. Wang, W. Gu, MiR-338 suppresses the growth and metastasis of OSCC cells by targeting NRP1. Mol. Cell. Biochem. 398, 115–122 (2015)

    Article  CAS  PubMed  Google Scholar 

  57. X. Yang, H. Wu, T. Ling, Suppressive effect of microRNA-126 on oral squamous cell carcinoma in vitro. Mol. Med. Rep. 10, 125–130 (2014)

    Article  CAS  PubMed  Google Scholar 

  58. F. Chen, S. Qi, X. Zhang, J. Wu, X. Yang, R. Wang, miR-23a-3p suppresses cell proliferation in oral squamous cell carcinomas by targeting FGF2 and correlates with a better prognosis: miR-23a-3p inhibits OSCC growth by targeting FGF2. Pathol. Res. Pract. 215, 660–667 (2019)

  59. M. Li, J. Ning, Z. Li, Q. Fei, C. Zhao, Y. Ge, L. Wang, Long noncoding RNA OIP5-AS1 promotes the progression of oral squamous cell carcinoma via regulating miR-338-3p/NRP1 axis. Biomed. Pharmacother. 118, 109259 (2019)

    Article  CAS  PubMed  Google Scholar 

  60. Y. Shao, Y. Qu, S. Dang, B. Yao, M. Ji, MiR-145 inhibits oral squamous cell carcinoma (OSCC) cell growth by targeting c-Myc and Cdk6. Cancer Cell Int. 13, 51 (2013)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  61. S. Fu, H.H. Chen, P. Cheng, C.B. Zhang, Y. Wu, MiR-155 regulates oral squamous cell carcinoma Tca8113 cell proliferation, cycle, and apoptosis via regulating p27Kip1. Eur. Rev. Med. Pharmacol. Sci. 21, 937–944 (2017)

    CAS  PubMed  Google Scholar 

  62. H.B. Xing, H.M. Qiu, Y. Li, P.F. Dong, X.M. Zhu, Long noncoding RNA CASC2 alleviates the growth, migration and invasion of oral squamous cell carcinoma via downregulating CDK1. Eur. Rev. Med. Pharmacol. Sci. 23, 4777–4783 (2019)

    PubMed  Google Scholar 

  63. H. Chi, miR-194 regulated AGK and inhibited cell proliferation of oral squamous cell carcinoma by reducing PI3K-Akt-FoxO3a signaling. Biomed. Pharmacother. 71, 53–57 (2015)

    Article  CAS  PubMed  Google Scholar 

  64. B. Rastogi, A. Kumar, S.K. Raut, N.K. Panda, V. Rattan, N. Joshi, M. Khullar, Downregulation of miR-377 promotes Oral squamous cell carcinoma growth and migration by targeting HDAC9. Cancer Investig. 35, 152–162 (2017)

    Article  CAS  Google Scholar 

  65. X. Niu, B. Yang, F. Liu, Q. Fang, LncRNA HOXA11-AS promotes OSCC progression by sponging miR-98-5p to upregulate YBX2 expression. Biomed. Pharmacother. 121, 109623 (2020)

    Article  CAS  PubMed  Google Scholar 

  66. Z. Wang, X. Zhu, P. Dong and J. Cai, Long noncoding RNA LINC00958 promotes the oral squamous cell carcinoma by sponging miR-185-5p/YWHAZ. Life Sci. 242, 116782 (2020)

  67. J. Tan, L. Xiang, G. Xu, LncRNA MEG3 suppresses migration and promotes apoptosis by sponging miR-548d-3p to modulate JAK-STAT pathway in oral squamous cell carcinoma. IUBMB Life 71, 882–890 (2019)

    Article  CAS  PubMed  Google Scholar 

  68. L. Wang, Y. Wei, Y. Yan, H. Wang, J. Yang, Z. Zheng, J. Zha, P. Bo, Y. Tang, X. Guo, W. Chen, X. Zhu, L. Ge, CircDOCK1 suppresses cell apoptosis via inhibition of miR196a5p by targeting BIRC3 in OSCC. Oncol. Rep. 39, 951–966 (2018)

    CAS  PubMed  Google Scholar 

  69. L. Chen, S. Zhang, J. Wu, J. Cui, L. Zhong, L. Zeng, S. Ge, circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family. Oncogene 36, 4551–4561 (2017)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  70. P. Xu, Y. Li, H. Zhang, M. Li, H. Zhu, MicroRNA-340 mediates metabolic shift in Oral squamous cell carcinoma by targeting glucose Transporter-1. J. Oral Maxillofac. Surg. 74, 844–850 (2016)

    Article  PubMed  Google Scholar 

  71. X. Sun, L. Zhang, MicroRNA-143 suppresses oral squamous cell carcinoma cell growth, invasion and glucose metabolism through targeting hexokinase 2. Biosci. Rep. 37, pii: BSR20160404 (2017)

  72. Y.H. Lai, H. Liu, W.F. Chiang, T.W. Chen, L.J. Chu, J.S. Yu, S.J. Chen, H.C. Chen, B.C. Tan, MiR-31-5p-ACOX1 Axis enhances tumorigenic fitness in Oral squamous cell carcinoma via the Promigratory prostaglandin E2. Theranostics 8, 486–504 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  73. H. Chu, Z. Li, Z. Gan, Z. Yang, Z. Wu, M. Rong, LncRNA ELF3-AS1 is involved in the regulation of oral squamous cell carcinoma cell proliferation by reprogramming glucose metabolism. Onco. Targets Ther 12, 6857–6863 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  74. C. Gao, C. Ren, Z. Liu, L. Zhang, R. Tang, X. Li, GAS5, a FoxO1-actived long noncoding RNA, promotes propofol-induced oral squamous cell carcinoma apoptosis by regulating the miR-1297-GSK3beta axis. Artif. Cells Nanomed. Biotechnol. 47, 3985–3993 (2019)

    Article  CAS  PubMed  Google Scholar 

  75. Z. Zheng, X. Luan, J. Zha, Z. Li, L. Wu, Y. Yan, H. Wang, D. Hou, L. Huang, F. Huang, H. Zheng, L. Ge, H. Guan, TNF-alpha inhibits the migration of oral squamous cancer cells mediated by miR-765-EMP3-p66Shc axis. Cell. Signal. 34, 102–109 (2017)

    Article  CAS  PubMed  Google Scholar 

  76. Y. Wu, L. Zhang, L. Zhang, Y. Wang, H. Li, X. Ren, F. Wei, W. Yu, T. Liu, X. Wang, X. Zhou, J. Yu, X. Hao, Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma. Int. J. Oncol. 46, 2586–2594 (2015)

    Article  CAS  PubMed  Google Scholar 

  77. L. Lu, X. Xue, J. Lan, Y. Gao, Z. Xiong, H. Zhang, W. Jiang, W. Song, Q. Zhi, MicroRNA-29a upregulates MMP2 in oral squamous cell carcinoma to promote cancer invasion and anti-apoptosis. Biomed. Pharmacother. 68, 13–19 (2014)

    Article  CAS  PubMed  Google Scholar 

  78. X.P. Kong, J. Yao, W. Luo, F.K. Feng, J.T. Ma, Y.P. Ren, D.L. Wang, R.F. Bu, The expression and functional role of a FOXC1 related mRNA-lncRNA pair in oral squamous cell carcinoma. Mol. Cell. Biochem. 394, 177–186 (2014)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Y. Wang, X. Zhang, Z. Wang, Q. Hu, J. Wu, Y. Li, X. Ren, T. Wu, X. Tao, X. Chen, X. Li, J. Xia, B. Cheng, LncRNA-p23154 promotes the invasion-metastasis potential of oral squamous cell carcinoma by regulating Glut1-mediated glycolysis. Cancer Lett. 434, 172–183 (2018)

    Article  CAS  PubMed  Google Scholar 

  80. Z. Zhuang, Nan Xie, J. Hu, P. Yu, C. Wang, X. Hu, X. Han, J. Hou, H. Huang and X. Liu, Interplay between ΔNp63 and miR-138-5p regulates growth, metastasis and stemness of oral squamous cell carcinoma. Oncotarget 8, 21954-21973 (2017)

  81. Y. Tian, L. Zhong, S. Gao, Y. Yu, D. Sun, X. Liu, J. Ji, Y. Yao, Y. Liu, Z. Jiang, LncRNA LINC00974 Downregulates miR-122 to Upregulate RhoA in Oral squamous cell carcinoma. Cancer Biother. Radiopharm. (2019). https://doi.org/10.1089/cbr.2019.2907

  82. G. Huang, X. He, X.L. Wei, lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR365/RGS20 in oral squamous cell carcinoma. Oncol. Rep. 39, 1948–1956 (2018)

    CAS  PubMed  Google Scholar 

  83. Y. Hui, Y. Li, Y. Jing, J.Q. Feng, Y. Ding, miRNA-101 acts as a tumor suppressor in oral squamous cell carcinoma by targeting CX chemokine receptor 7. Am. J. Transl. Res. 8, 4902–4911 (2016)

    CAS  PubMed  PubMed Central  Google Scholar 

  84. S.C. Casey, A. Amedei, K. Aquilano, A.S. Azmi, F. Benencia, D. Bhakta, A.E. Bilsland, C.S. Boosani, S. Chen, M.R. Ciriolo, S. Crawford, H. Fujii, A.G. Georgakilas, G. Guha, D. Halicka, W.G. Helferich, P. Heneberg, K. Honoki, W.N. Keith, S.P. Kerkar, S.I. Mohammed, E. Niccolai, S. Nowsheen, H.P.V. Rupasinghe, A. Samadi, N. Singh, W.H. Talib, V. Venkateswaran, R.L. Whelan, X. Yang, D.W. Felsher, Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin. Cancer Biol. 35(Suppl), S199–S223 (2015)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  85. P. Nilendu, S.C. Sarode, D. Jahagirdar, I. Tandon, S. Patil, G.S. Sarode, J.K. Pal, N.K. Sharma, Mutual concessions and compromises between stromal cells and cancer cells: Driving tumor development and drug resistance. Cell. Oncol. 41, 353–367 (2018)

    Article  CAS  Google Scholar 

  86. A. Salmaninejad, S.F. Valilou, A. Soltani, S. Ahmadi, Y.J. Abarghan, R.J. Rosengren, A. Sahebkar, Tumor-associated macrophages: Role in cancer development and therapeutic implications. Cell. Oncol. 42, 591–608 (2019)

    Article  Google Scholar 

  87. T. Sasahira, M. Kurihara, U.K. Bhawal, N. Ueda, T. Shimomoto, K. Yamamoto, T. Kirita, H. Kuniyasu, Downregulation of miR-126 induces angiogenesis and lymphangiogenesis by activation of VEGF-A in oral cancer. Br. J. Cancer 107, 700–706 (2012)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  88. Y.Y. Wu, Y.L. Chen, Y.C. Jao, I.S. Hsieh, K.C. Chang, T.M. Hong, miR-320 regulates tumor angiogenesis driven by vascular endothelial cells in oral cancer by silencing neuropilin 1. Angiogenesis 17, 247–260 (2014)

    Article  CAS  PubMed  Google Scholar 

  89. L. Li, C. Li, S. Wang, Z. Wang, J. Jiang, W. Wang, X. Li, J. Chen, K. Liu, C. Li, G. Zhu, Exosomes derived from hypoxic Oral squamous cell carcinoma cells deliver miR-21 to normoxic cells to elicit a Prometastatic phenotype. Cancer Res. 76, 1770–1780 (2016)

    Article  CAS  PubMed  Google Scholar 

  90. T. Kawakubo-Yasukochi, M. Morioka, M. Hazekawa, A. Yasukochi, T. Nishinakagawa, K. Ono, S. Kawano, S. Nakamura, M. Nakashima, miR-200c-3p spreads invasive capacity in human oral squamous cell carcinoma microenvironment. Mol. Carcinog. 57, 295–302 (2018)

    Article  CAS  PubMed  Google Scholar 

  91. T. Liu, G. Chen, D. Sun, M. Lei, Y. Li, C. Zhou, X. Li, W. Xue, H. Wang, C. Liu, J. Xu, Exosomes containing miR-21 transfer the characteristic of cisplatin resistance by targeting PTEN and PDCD4 in oral squamous cell carcinoma. Acta Biochim. Biophys. Sin. Shanghai 49, 808–816 (2017)

    Article  CAS  PubMed  Google Scholar 

  92. N. Eiro, L. Gonzalez, A. Martinez-Ordonez, B. Fernandez-Garcia, L.O. Gonzalez, S. Cid, F. Dominguez, R. Perez-Fernandez, F.J. Vizoso, Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis. Cell. Oncol. 41, 369–378 (2018)

    Article  CAS  Google Scholar 

  93. Y.Y. Li, Y.W. Tao, S. Gao, P. Li, J.M. Zheng, S.E. Zhang, J. Liang, Y. Zhang, Cancer-associated fibroblasts contribute to oral cancer cells proliferation and metastasis via exosome-mediated paracrine miR-34a-5p. EBioMedicine 36, 209–220 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  94. L.P. Sun, K. Xu, J. Cui, D.Y. Yuan, B. Zou, J. Li, J.L. Liu, K.Y. Li, Z. Meng, B. Zhang, Cancerassociated fibroblastderived exosomal miR3825p promotes the migration and invasion of oral squamous cell carcinoma. Oncol. Rep. 42, 1319–1328 (2019)

    CAS  PubMed  PubMed Central  Google Scholar 

  95. J. Cai, B. Qiao, N. Gao, N. Lin, W. He, Oral squamous cell carcinoma-derived exosomes promote M2 subtype macrophage polarization mediated by exosome-enclosed miR-29a-3p. Am. J. Physiol. Cell Physiol. 316, C731–c740 (2019)

    Article  CAS  PubMed  Google Scholar 

  96. F. Momen-Heravi, S. Bala, Extracellular vesicles in oral squamous carcinoma carry oncogenic miRNA profile and reprogram monocytes via NF-kappaB pathway. Oncotarget 9, 34838–34854 (2018)

    Article  PubMed  PubMed Central  Google Scholar 

  97. D. Huang, J. Chen, L. Yang, Q. Ouyang, J. Li, L. Lao, J. Zhao, J. Liu, Y. Lu, Y. Xing, F. Chen, F. Su, H. Yao, Q. Liu, S. Su, E. Song, NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death. Nat. Immunol. 19, 1112–1125 (2018)

    Article  CAS  PubMed  Google Scholar 

  98. L.J. Sang, H.Q. Ju, G.P. Liu, T. Tian, G.L. Ma, Y.X. Lu, Z.X. Liu, R.L. Pan, R.H. Li, H.L. Piao, J.R. Marks, L.J. Yang, Q. Yan, W. Wang, J. Shao, Y. Zhou, T. Zhou, A. Lin, LncRNA CamK-A Regulates Ca(2+)-Signaling-Mediated Tumor Microenvironment Remodeling. Mol. Cell 72, 71–83.e77 (2018)

    Article  CAS  PubMed  Google Scholar 

  99. Z.L. Ou, Z. Luo, W. Wei, S. Liang, T.L. Gao, Y.B. Lu, Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: Role of circ_0000977/miR-153 axis. RNA Biol. 16, 1592–1603 (2019)

    Article  PubMed  PubMed Central  Google Scholar 

  100. F. Zahran, D. Ghalwash, O. Shaker, K. Al-Johani, C. Scully, Salivary microRNAs in oral cancer. Oral Dis. 21, 739–747 (2015)

    Article  CAS  PubMed  Google Scholar 

  101. E.A. Gibb, K.S. Enfield, G.L. Stewart, K.M. Lonergan, R. Chari, R.T. Ng, L. Zhang, C.E. MacAulay, M.P. Rosin, W.L. Lam, Long non-coding RNAs are expressed in oral mucosa and altered in oral premalignant lesions. Oral Oncol. 47, 1055–1061 (2011)

    Article  CAS  PubMed  Google Scholar 

  102. Y.C. Lu, J.T. Chang, Y.C. Huang, C.C. Huang, W.H. Chen, L.Y. Lee, B.S. Huang, Y.J. Chen, H.F. Li, A.J. Cheng, Combined determination of circulating miR-196a and miR-196b levels produces high sensitivity and specificity for early detection of oral cancer. Clin. Biochem. 48, 115–121 (2015)

    Article  CAS  PubMed  Google Scholar 

  103. F. Momen-Heravi, A.J. Trachtenberg, W.P. Kuo, Y.S. Cheng, Genomewide Study of Salivary MicroRNAs for Detection of Oral Cancer. J. Dent. Res. 93, 86s–93s (2014)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  104. C. Zhao, H. Zou, J. Wang, J. Shen, H. Liu, A three long noncoding RNA-based signature for Oral squamous cell carcinoma prognosis prediction. DNA Cell Biol. 37, 888–895 (2018)

    Article  CAS  PubMed  Google Scholar 

  105. S.Y. Zhao, J. Wang, S.B. Ouyang, Z.K. Huang, L. Liao, Salivary circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as novel biomarkers for the diagnosis of Oral squamous cell carcinoma. Cell. Physiol. Biochem. 47, 2511–2521 (2018)

    Article  CAS  PubMed  Google Scholar 

  106. J. Li, H. Huang, L. Sun, M. Yang, C. Pan, W. Chen, D. Wu, Z. Lin, C. Zeng, Y. Yao, P. Zhang, E. Song, MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitor. Clin. Cancer Res. 15, 3998–4008 (2009)

    Article  CAS  PubMed  Google Scholar 

  107. X. Li, C. Ma, L. Zhang, N. Li, X. Zhang, J. He, R. He, M. Shao, J. Wang, L. Kang, C. Han, LncRNAAC132217.4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregulating IGF2 expression. Cancer Lett. 407, 45–56 (2017)

    Article  CAS  PubMed  Google Scholar 

  108. X. Xia, X. Li, F. Li, X. Wu, M. Zhang, H. Zhou, N. Huang, X. Yang, F. Xiao, D. Liu, L. Yang, N. Zhang, A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1. Mol. Cancer 18, 131 (2019)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  109. G. Yuan, H. Wu, Y. Du, F. He, Tumor suppressor role of microRNA-545 in oral squamous cell carcinoma. Oncol. Lett. 17, 2063–2068 (2019)

    CAS  PubMed  Google Scholar 

  110. L.O. Reis, T.C. Pereira, I. Lopes-Cendes, U. Ferreira, MicroRNAs: A new paradigm on molecular urological oncology. Urology 76, 521–527 (2010)

    Article  PubMed  Google Scholar 

  111. Z. Fang, J. Zhao, W. Xie, Q. Sun, H. Wang, B. Qiao, LncRNA UCA1 promotes proliferation and cisplatin resistance of oral squamous cell carcinoma by sunppressing miR-184 expression. Cancer Med. 6, 2897–2908 (2017)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  112. S. Hunt, A.V. Jones, E.E. Hinsley, S.A. Whawell, D.W. Lambert, MicroRNA-124 suppresses oral squamous cell carcinoma motility by targeting ITGB1. FEBS Lett. 585, 187–192 (2011)

    Article  CAS  PubMed  Google Scholar 

  113. A. Tiwari, S. Shivananda, K.S. Gopinath, A. Kumar, MicroRNA-125a reduces proliferation and invasion of oral squamous cell carcinoma cells by targeting estrogen-related receptor alpha: Implications for cancer therapeutics. J. Biol. Chem. 289, 32276–32290 (2014)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  114. A. Bufalino, N.K. Cervigne, C.E. de Oliveira, F.P. Fonseca, P.C. Rodrigues, C.C. Macedo, L.M. Sobral, M.C. Miguel, M.A. Lopes, A.F. Paes Leme, D.W. Lambert, T.A. Salo, L.P. Kowalski, E. Graner, R.D. Coletta, Low miR-143/miR-145 cluster levels induce Activin a overexpression in Oral squamous cell carcinomas, which contributes to poor prognosis. PLoS One 10, e0136599 (2015)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  115. Q. Zeng, X. Tao, F. Huang, T. Wu, J. Wang, X. Jiang, Z. Kuang, B. Cheng, Overexpression of miR-155 promotes the proliferation and invasion of oral squamous carcinoma cells by regulating BCL6/cyclin D2. Int. J. Mol. Med. 37, 1274–1280 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  116. K.H. Shin, S.D. Bae, H.S. Hong, R.H. Kim, M.K. Kang, N.H. Park, miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras. Biochem. Biophys. Res. Commun. 404, 896–902 (2011)

    Article  CAS  PubMed  Google Scholar 

  117. Z. Cai, X.Y. Hao, F.X. Liu, MicroRNA-186 serves as a tumor suppressor in oral squamous cell carcinoma by negatively regulating the protein tyrosine phosphatase SHP2 expression. Arch. Oral Biol. 89, 20–25 (2018)

    Article  CAS  PubMed  Google Scholar 

  118. L. Li, H.Q. Ma, MicroRNA-216a inhibits the growth and metastasis of oral squamous cell carcinoma by targeting eukaryotic translation initiation factor 4B. Mol. Med. Rep. 12, 3156–3162 (2015)

    Article  CAS  PubMed  Google Scholar 

  119. A. Uesugi, K. Kozaki, T. Tsuruta, M. Furuta, K. Morita, I. Imoto, K. Omura, J. Inazawa, The tumor suppressive microRNA miR-218 targets the mTOR component Rictor and inhibits AKT phosphorylation in oral cancer. Cancer Res. 71, 5765–5778 (2011)

    Article  CAS  PubMed  Google Scholar 

  120. F. Jiang, W. Zhao, L. Zhou, L. Zhang, Z. Liu, D. Yu, miR-222 regulates the cell biological behavior of oral squamous cell carcinoma by targeting PUMA. Oncol. Rep. 31, 1255–1262 (2014)

    Article  CAS  PubMed  Google Scholar 

  121. C.N. Yang, Y.T. Deng, J.Y. Tang, S.J. Cheng, S.T. Chen, Y.J. Li, T.S. Wu, M.H. Yang, B.R. Lin, M.Y. Kuo, J.Y. Ko, C.C. Chang, MicroRNA-29b regulates migration in oral squamous cell carcinoma and its clinical significance. Oral Oncol. 51, 170–177 (2015)

    Article  CAS  PubMed  Google Scholar 

  122. X. Yang, H. Ruan, X. Hu, A. Cao, L. Song, miR-381-3p suppresses the proliferation of oral squamous cell carcinoma cells by directly targeting FGFR2, am. J. Cancer Res. Ther. 7, 913–922 (2017)

  123. H.Y. Peng, S.S. Jiang, J.R. Hsiao, M. Hsiao, Y.M. Hsu, G.H. Wu, W.M. Chang, J.Y. Chang, S.L. Jin, S.G. Shiah, IL-8 induces miR-424-5p expression and modulates SOCS2/STAT5 signaling pathway in oral squamous cell carcinoma. Mol. Oncol. 10, 895–909 (2016)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  124. C.M. Cheng, S.G. Shiah, C.C. Huang, J.R. Hsiao, J.Y. Chang, Up-regulation of miR-455-5p by the TGF-beta-SMAD signalling axis promotes the proliferation of oral squamous cancer cells by targeting UBE2B. J. Pathol. 240, 38–49 (2016)

    Article  CAS  PubMed  Google Scholar 

  125. J. Hu, J.F. Xu, W.L. Ge, MiR-497 enhances metastasis of oral squamous cell carcinoma through SMAD7 suppression. Am. J. Transl. Res. 8, 3023–3031 (2016)

    CAS  PubMed  PubMed Central  Google Scholar 

  126. T. Yu, K. Liu, Y. Wu, J. Fan, J. Chen, C. Li, Q. Yang, Z. Wang, MicroRNA-9 inhibits the proliferation of oral squamous cell carcinoma cells by suppressing expression of CXCR4 via the Wnt/beta-catenin signaling pathway. Oncogene 33, 5017–5027 (2014)

    Article  CAS  PubMed  Google Scholar 

  127. Y. Du, Y. Li, H. Lv, S. Zhou, Z. Sun, M. Wang, miR-98 suppresses tumor cell growth and metastasis by targeting IGF1R in oral squamous cell carcinoma. Int. J. Clin. Exp. Pathol. 8, 12252–12259 (2015)

    CAS  PubMed  PubMed Central  Google Scholar 

  128. Y.C. Yen, S.G. Shiah, H.C. Chu, Y.M. Hsu, J.R. Hsiao, J.Y. Chang, W.C. Hung, C.T. Liao, A.J. Cheng, Y.C. Lu, Y.W. Chen, Reciprocal regulation of microRNA-99a and insulin-like growth factor I receptor signaling in oral squamous cell carcinoma cells. Mol. Cancer 13, 6 (2014)

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  129. T.R. Shao, Z.N. Zheng, Y.C. Chen, Q.Q. Wu, G.Z. Huang, F. Li, W.S. Zeng, X.Z. Lv, LncRNA AC007271.3 promotes cell proliferation, invasion, migration and inhibits cell apoptosis of OSCC via the Wnt/beta-catenin signaling pathway. Life Sci. 239, 117087 (2019)

    Article  CAS  PubMed  Google Scholar 

  130. L. Liu, S.B. Ning, S. Fu, Y. Mao, M. Xiao, B. Guo, Effects of lncRNA ANRIL on proliferation and apoptosis of oral squamous cell carcinoma cells by regulating TGF-beta/Smad pathway. Eur. Rev. Med. Pharmacol. Sci. 23, 6194–6201 (2019)

    CAS  PubMed  Google Scholar 

  131. C. Yao, F. Kong, S. Zhang, G. Wang, P. She, Q. Zhang, Long non-coding RNA BANCR promotes proliferation and migration in oral squamous cell carcinoma via MAPK signaling pathway. J. Oral Pathol. Med. (2019). https://doi.org/10.1111/jop.12968

  132. D. Dai, X.D. Feng, W.Q. Zhu, Y.N. Bao, LncRNA BLACAT1 regulates the viability, migration and invasion of oral squamous cell carcinoma cells by targeting miR-142-5p. Eur. Rev. Med. Pharmacol. Sci. 23, 10313–10323 (2019)

    CAS  PubMed  Google Scholar 

  133. X. Zhang, B. Guo, Y. Zhu, W. Xu, S. Ning, L. Liu, Up-regulation of plasma lncRNA CACS15 distinguished early-stage oral squamous cell carcinoma patient. Oral Dis. (2019). https://doi.org/10.1111/odi.13245

  134. J. Ye, Y. Jiao, LncRNA FAL1 promotes the development of oral squamous cell carcinoma through regulating the microRNA-761/CRKL pathway. Eur. Rev. Med. Pharmacol. Sci. 23, 5779–5786 (2019)

    CAS  PubMed  Google Scholar 

  135. B. Jia, T. Xie, X. Qiu, X. Sun, J. Chen, Z. Huang, X. Zheng, Z. Wang, J. Zhao, Long noncoding RNA FALEC inhibits proliferation and metastasis of tongue squamous cell carcinoma by epigenetically silencing ECM1 through EZH2. Aging (Albany NY) 11, 4990–5007 (2019)

    Article  CAS  Google Scholar 

  136. L. Xu, T.J. Hou, P. Yang, Mechanism of lncRNA FEZF1-AS1 in promoting the occurrence and development of oral squamous cell carcinoma through targeting miR-196a. Eur. Rev. Med. Pharmacol. Sci. 23, 6505–6515 (2019)

    CAS  PubMed  Google Scholar 

  137. Y. Hong, H. He, W. Sui, J. Zhang, S. Zhang, D. Yang, Long non-coding RNA H1 promotes cell proliferation and invasion by acting as a ceRNA of miR138 and releasing EZH2 in oral squamous cell carcinoma. Int. J. Oncol. 52, 901–912 (2018)

    CAS  PubMed  Google Scholar 

  138. J. Zhao, X. Bai, C. Feng, X. Shang, Y. Xi, Long non-coding RNA HCP5 facilitates cell invasion and epithelial-Mesenchymal transition in Oral squamous cell carcinoma by miR-140-5p/SOX4 Axis. Cancer Manag. Res. 11, 10455–10462 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  139. M. Li, J. Ning, Z. Li, J. Wang, C. Zhao, L. Wang, LINC00152 promotes the growth and invasion of oral squamous cell carcinoma by regulating miR-139-5p. Onco. Targets Ther. 11, 6295–6304 (2018)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  140. Y. Jiang, W. Cao, K. Wu, X. Qin, X. Wang, Y. Li, B. Yu, Z. Zhang, X. Wang, M. Yan, Q. Xu, J. Zhang, W. Chen, LncRNA LINC00460 promotes EMT in head and neck squamous cell carcinoma by facilitating peroxiredoxin-1 into the nucleus. J. Exp. Clin. Cancer Res.: CR 38, 365 (2019)

    Article  PubMed  CAS  PubMed Central  Google Scholar 

  141. C.Z. Zhang, Long intergenic non-coding RNA 668 regulates VEGFA signaling through inhibition of miR-297 in oral squamous cell carcinoma. Biochem. Biophys. Res. Commun. 489, 404–412 (2017)

    Article  CAS  PubMed  Google Scholar 

  142. Z. Chen, Q. Tao, B. Qiao, L. Zhang, Silencing of LINC01116 suppresses the development of oral squamous cell carcinoma by up-regulating microRNA-136 to inhibit FN1. Cancer Manag. Res. 11, 6043–6059 (2019)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  143. Y. Kong, Y. Feng, Y.Y. Xiao, S.C. Liu, X.G. Li, Q.L. Yang, W.H. Chu, J.G. Liu, LncRNA LUCAT1 promotes rowth, migration, and invasion of oral squamous cell carcinoma by upregulating PCNA. Eur. Rev. Med. Pharmacol. Sci. 23, 4770–4776 (2019)

    CAS  PubMed  Google Scholar 

  144. S.M. Chang, W.W. Hu, Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis. J. Cell. Physiol. 233, 3384–3396 (2018)

    Article  CAS  PubMed  Google Scholar 

  145. C.C. Sun, L. Zhang, G. Li, S.J. Li, Z.L. Chen, Y.F. Fu, F.Y. Gong, T. Bai, D.Y. Zhang, Q.M. Wu, D.J. Li, The lncRNA PDIA3P interacts with miR-185-5p to modulate Oral squamous cell carcinoma progression by targeting Cyclin D2. Mol. Ther. Nucleic. Acids 9, 100–110 (2017)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  146. J. Wu, W. Zhao, Z. Wang, X. Xiang, S. Zhang, L. Liu, Long non-coding RNA SNHG20 promotes the tumorigenesis of oral squamous cell carcinoma via targeting miR-197/LIN28 axis. J. Cell. Mol. Med. 23, 680–688 (2019)

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

This work was supported by the National Natural Science Foundation of China (Nos. 81672675, 81872211 and 81621062), the 111 Project of MOE China (Grant No. B14038) and the Sichuan University Innovation and Entrepreneurship Training Program for Undergraduates (No. C2019106455).

Author information

Authors and Affiliations

  1. State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, People’s Republic of China

    Fei Huang, Chuan Xin, Kexin Lei, Hetian Bai, Jing Li & Qianming Chen

Authors
  1. Fei Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chuan Xin
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kexin Lei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hetian Bai
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Jing Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qianming Chen
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

FH wrote the manuscript and designed the figures; CX, HB and KL collected the related references and edited the manuscript; QC and JL provided guidance and revised this manuscript. All authors approved the final manuscript.

Corresponding author

Correspondence to Jing Li.

Ethics declarations

Ethics approval and consent to participate

Not applicable.

Conflict of interest

The authors declare that they have no conflict of interest.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, F., Xin, C., Lei, K. et al. Noncoding RNAs in oral premalignant disorders and oral squamous cell carcinoma. Cell Oncol. 43, 763–777 (2020). https://doi.org/10.1007/s13402-020-00521-9

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s13402-020-00521-9

Keywords

Search

Navigation