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Respiratory Characteristics of Rat Liver Mitochondria Depend on the Duration of Moderate Hypothermia

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Bulletin of Experimental Biology and Medicine Aims and scope

The development of pathological or compensatory-and-adaptive reactions in homoeothermic animals during various periods of hypothermia can be caused by shifts in the respiratory functions of the mitochondria. Short-term hypothermia promoted an increase in the rates of the glutamate- and succinate-dependent respiration of mitochondria. Phosphorylation rate increased as well, while oxidative phosphorylation coefficient (P/O), respiratory control, and 2,4-DNP sensitivity depended. Changes in respiratory characteristics in the dynamics of prolonged hypothermia depends on the type of substrate. Prolongation of hypothermia to 1 h was associated with further intensification of succinate-dependent respiration, decrease in P/O and respiratory control, while prolongation of hypothermia to 3 h led to their normalization. The majority of respiratory characteristics of glutamate-dependent respiration did not change under these conditions and their levels were the same as during short-term hypothermia.

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Authors and Affiliations

  1. Department of Biochemistry and Biophysics, Dagestan State University, Makhachkala, Dagestan Republic, Russia

    R. A. Khalilov, S. I. Khizrieva, A. M. Dzhafarova & V. R. Abdullaev

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  1. R. A. Khalilov
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  2. S. I. Khizrieva
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  3. A. M. Dzhafarova
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  4. V. R. Abdullaev
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Correspondence to A. M. Dzhafarova.

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Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 169, No. 1, pp. 33-38, January, 2020

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Khalilov, R.A., Khizrieva, S.I., Dzhafarova, A.M. et al. Respiratory Characteristics of Rat Liver Mitochondria Depend on the Duration of Moderate Hypothermia. Bull Exp Biol Med 169, 29–34 (2020). https://doi.org/10.1007/s10517-020-04817-6

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  • DOI: https://doi.org/10.1007/s10517-020-04817-6

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