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Release Kinetic Model and Antimicrobial Activity of Freeze-Dried Curcumin-loaded Bacterial Nanocellulose Composite

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Abstract

Naturally antibacterial-based materials are of interest for biomedical application specifically in wound dressing. The use of bioactive substance such as curcumin in combination with naturally abundant biopolymer bacterial nanocellulose (BNC), offers the best solution to achieve such material. In this study, a composite membrane comprising of curcumin particles and BNC were prepared using immersion method. The curcumin-loaded BNC (Cur-BNC) composite was characterized in terms of its morphology and chemical structure using field-emission scanning electron microscope (FE-SEM), and Fourier transform infrared spectrometry, respectively. The result confirmed successful incorporation of curcumin into BNC with the presence of curcumin in fibrillar network structure. The water absorption capacity and swelling ratio were evaluated, and the composite recorded water absorption rate above 150% in agreement with standard YY0148-2006. The release assay and mathematical modeling studies indicated a slow and sustained release profile which was best interpreted by the Higuchi model. For antibacterial study, the curcumin soaked BNC showed antimicrobial action against Staphylococcus aureus and Escherichia coli. The sample with the highest curcumin concentration of 1.0 mg/mL exhibited high log reduction of 2.63 with 98% killing ratio against the viable cells of S. aureus after 24 h of contact. The Cur-BNC composite showed great potential as a promising candidate for wound dressing.

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REFERENCES

  1. S. -K. Han, Innovations and Advances in Wound Healing (Springer, Berlin; Heidelberg, 2015).

    Google Scholar 

  2. C. J. Chirayil, J. Joy, L. Mathew, J. Koetz, and S. Thomas, Ind. Crops Prod. 56, 246 (2014).

    Article  CAS  Google Scholar 

  3. A. Mihranyan, J. Appl. Polym. Sci. 119, 2449 (2011).

    Article  CAS  Google Scholar 

  4. P. Ross, R. Mayer, and M. Benziman, Microbiol. Rev. 55, 35 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. P. R. Chawla, I. B. Bajaj, S. A. Survase, and R. S. Singhal, Food Technol. Biotechnol. 47, 107 (2009).

    CAS  Google Scholar 

  6. O.-A. Saibuatong and M. Phisalaphong, Carbohydr. Polym. 79, 455 (2010).

    Article  CAS  Google Scholar 

  7. D. Klemm, B. Heublein, H.-P. Fink, and A. Bohn, Angew. Chem., Int. Ed. 44, 3358 (2005).

    Article  CAS  Google Scholar 

  8. W. Hu, S. Chen, J. Yang, Z. Li, and H. Wang, Carbohydr. Polym. 101, 1043 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. G. Helenius, H. Bäckdahl, A. Bodin, U. Nannmark, P. Gatenholm, and B. Risberg, J. Biomed. Mater. Res., Part A 76A, 431 (2006).

    CAS  Google Scholar 

  10. W. K. Czaja, D. J. Young, M. Kawecki, and R. M. Brown, Biomacromolecules 8, 1 (2007).

    Article  CAS  PubMed  Google Scholar 

  11. S. Torgbo and P. Sukyai, Appl. Mater. Today 11, 34 (2018).

    Article  Google Scholar 

  12. Y. Fan, E. Sharbrough, and H. Liu, Environ. Sci. Technol. 42, 8101 (2008).

    Article  CAS  PubMed  Google Scholar 

  13. S. M. Keshk, J. Bioprocess. Biotech. 4, 1 (2014).

    Article  CAS  Google Scholar 

  14. J. Shah and R. Malcolm Brown, Appl. Microbiol. Biotech. 66, 352 (2005).

    Article  CAS  Google Scholar 

  15. M. Iguchi, S. Yamanaka, and A. Budhiono, J. Mater. Sci. 35, 261 (2000).

    Article  CAS  Google Scholar 

  16. H. G. Oliveira Barud, H. D. S. Barud, M. Cavicchioli, T. S. do Amaral, O. B. D. O. Junior, D. M. Santos, A. L. D. O. A. Petersen, F. Celes, V. M. Borges, C. I. de Oliveira, P. F. de Oliveira, R. A. Furtado, D. C. Tavares, and S. J. L. Ribeiro, Carbohydr. Polym. 128, 41 (2015).

    Article  CAS  PubMed  Google Scholar 

  17. W. Czaja, A. Krystynowicz, S. Bielecki, and R. M. Brown, Biomaterials 27, 145 (2006).

    Article  CAS  PubMed  Google Scholar 

  18. D. Klemm, D. Schumann, U. Udhardt, and S. Marsch, Prog. Polym. Sci. 26, 1561 (2001).

    Article  CAS  Google Scholar 

  19. A. Svensson, E. Nicklasson, T. Harrah, B. Panilaitis, D. L. Kaplan, M. Brittberg, and P. Gatenholm, Biomaterials 26, 419 (2005).

    Article  CAS  PubMed  Google Scholar 

  20. S. Torgbo and P. Sukyai, Mater. Chem. Phys. 237, 121868 (2019).

    Article  CAS  Google Scholar 

  21. T. Maneerung, S. Tokura, and R. Rujiravanit, Carbohydr. Polym. 72, 43 (2008).

    Article  CAS  Google Scholar 

  22. W. Hu, S. Chen, B. Zhou, and H. Wang, Mater. Sci. Eng., B 170, 88 (2010).

    Article  CAS  Google Scholar 

  23. R. J. B. Pinto, S. Daina, P. Sadocco, C. P. Neto, and T. Trindade, Biomed. Res. Int. 2013, 6 (2013).

    Article  CAS  Google Scholar 

  24. C. Beer, R. Foldbjerg, Y. Hayashi, D. S. Sutherland, and H. Autrup, Toxicol. Lett. 208, 286 (2012).

    Article  CAS  PubMed  Google Scholar 

  25. P. V. AshaRani, G. Low Kah Mun, M. P. Hande, and S. Valiyaveettil, ACS Nano 3, 279 (2009).

  26. R. J. Vandebriel and W. H. De Jong, Nanotech. Sci. Appl. 5, 61 (2012).

    Article  CAS  Google Scholar 

  27. S. H. Lee, H. R. Lee, Y.-R. Kim, and M.-K. Kim, Toxicol. Environ. Health Sci. 4, 14 (2012).

    Article  Google Scholar 

  28. R. K. Maheshwari, A. K. Singh, J. Gaddipati, and R. C. Srimal, Life Sci. 78, 2081 (2006).

    Article  CAS  PubMed  Google Scholar 

  29. G. S. Sidhu, A. K. Singh, D. Thaloor, K. K. Banaudha, G. K. Patnaik, R. C. Srimal, and R. K. Maheshwari, Wound Repair Regener. 6, 167 (1998).

    Article  CAS  Google Scholar 

  30. G. S. Sidhu, H. Mani, J. P. Gaddipati, A. K. Singh, P. Seth, K. K. Banaudha, G. K. Patnaik, and R. K. Maheshwari, Wound Repair Regener. 7, 362 (1999).

    Article  CAS  Google Scholar 

  31. P. Ross, R. Mayer, and M. Benziman, Microbiol. Rev. 55, 35 (1991).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. R. L. Dahlin, F. K. Kasper, and A. G. Mikos, Tissue Eng., Part B 17, 349 (2011).

    CAS  Google Scholar 

  33. N. Ahuja, O. P. Katare, and B. Singh, Eur. J. Pharm. Biopharm. 65, 26 (2007).

    Article  CAS  PubMed  Google Scholar 

  34. M. Phisalaphong and N. Jatupaiboon, Carbohydr. Polym. 74, 482 (2008).

    Article  CAS  Google Scholar 

  35. G. Yang, J. Xie, F. Hong, Z. Cao, and X. Yang, Carbohydr. Polym. 87, 839 (2012).

    Article  CAS  Google Scholar 

  36. C. Clasen, B. Sultanova, T. Wilhelms, P. Heisig, and W.-M. Kulicke, Macromol. Symp. 244, 48 (2006).

    Article  CAS  Google Scholar 

  37. H. S. Barud, A. M. de Araújo, Jr., D. B. Santos, R. M. N. de Assunção, C. S. Meireles, D. A. Cerqueira, G. Rodrigues Filho, C. A. Ribeiro, Y. Messaddeq, and S. J. L. Ribeiro, Thermochim. Acta 471, 61 (2008).

    Article  CAS  Google Scholar 

  38. T. M. Kolev, E. A. Velcheva, B. A. Stamboliyska, and M. Spiteller, Int. J. Quantum Chem. 102, 1069 (2005).

    Article  CAS  Google Scholar 

  39. M. Dyson, S. Young, C. L. Pendle, D. F. Webster, and S. M. Lang, J. Invest. Dermatol. 91, 434 (1988).

    Article  CAS  PubMed  Google Scholar 

  40. W.-C. Lin, C.-C. Lien, H.-J. Yeh, C.-M. Yu, and S.‑H. Hsu, Carbohydr. Polym. 94, 603 (2013).

    Article  CAS  PubMed  Google Scholar 

  41. M. Ul-Islam, N. Shah, J. H. Ha, and J. K. Park, Korean J. Chem. Eng. 28, 1736 (2011).

    Article  CAS  Google Scholar 

  42. E. Jaruga, A. Sokal, S. Chrul, and G. Bartosz, Exp. Cell Res. 245, 303 (1998).

    Article  CAS  PubMed  Google Scholar 

  43. N. P. Aditya, S. Aditya, H. Yang, H. W. Kim, S. O. Park, and S. Ko, Food Chem. 173, 7 (2015).

    Article  CAS  PubMed  Google Scholar 

  44. S. K. Bajpai, N. Chand, S. Ahuja, and M. K. Roy, Int. J. Biol. Macromol. 75, 239 (2015).

    Article  CAS  PubMed  Google Scholar 

  45. M. Ul-Islam, T. Khan, and J. K. Park, Carbohydr. Polym. 88, 596 (2012).

    Article  CAS  Google Scholar 

  46. O. Suwantong, P. Opanasopit, U. Ruktanonchai, and P. Supaphol, Polymer 48, 7546 (2007).

    Article  CAS  Google Scholar 

  47. S. Li, L. Li, C. Guo, H. Qin, and X. Yu, Int. J. Biol. Macromol. 104, 969 (2017).

    Article  CAS  PubMed  Google Scholar 

  48. W. Cui, X. Li, X. Zhu, G. Yu, S. Zhou, and J. Weng, Biomacromolecules 7, 1623 (2006).

    Article  CAS  PubMed  Google Scholar 

  49. P. Costa and J. M. Sousa Lobo, Eur. J. Pharm. Sci. 13, 123 (2001).

    Article  CAS  PubMed  Google Scholar 

  50. S. Radin, T. Chen, and P. Ducheyne, Biomaterials 30, 850 (2009).

    Article  CAS  PubMed  Google Scholar 

  51. P. Pisitsak and U. Ruktanonchai, Text. Res. J. 85, 949 (2014).

    Article  CAS  Google Scholar 

  52. H. Y. Zhou, P. P. Cao, J. B. Li, F. L. Zhang, and P. P. Ding, J. Appl. Polym. Sci. 132, 42152 (2015).

    Google Scholar 

  53. C. L. Gallant-Behm, H. Q. Yin, S. Liu, J. P. Heggers, R. E. Langford, M. E. Olson, D. A. Hart, and R. E. Burrell, Wound Repair Regener. 13, 412 (2005).

    Article  Google Scholar 

  54. Bhawana, R. K. Basniwal, H. S. Buttar, V. K. Jain, and N. Jain, J. Agric. Food Chem. 59, 2056 (2011).

    Article  CAS  PubMed  Google Scholar 

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Funding

The authors are grateful to the Kasetsart University Research and Development Institute (KURDI) for financial support, the Department of Biotechnology, Faculty of Agro-Industry, and to Kasetsart University for supplying facilities.

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Authors and Affiliations

  1. Biotechnology of Biopolymer and Bioactive Compounds Special Research Unit, Department of Biotechnology, Faculty of Agro-Industry, Kasetsart University, 10900, Chatuchak, Bangkok, Thailand

    Vachanont Tangsatianpan, Selorm Torgbo & Prakit Sukyai

  2. Center for Advanced Studies for Agriculture and Food, Kasetsart University Institute for Advanced Studies, Kasetsart University, Bangkok, Thailand

    Prakit Sukyai

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  1. Vachanont Tangsatianpan
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Correspondence to Prakit Sukyai.

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Vachanont Tangsatianpan, Torgbo, S. & Sukyai, P. Release Kinetic Model and Antimicrobial Activity of Freeze-Dried Curcumin-loaded Bacterial Nanocellulose Composite. Polym. Sci. Ser. A 62, 218–227 (2020). https://doi.org/10.1134/S0965545X20030153

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  • DOI: https://doi.org/10.1134/S0965545X20030153

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