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The Ability of Pluronics to Increase the Survival Rate of Cells Determined by a Hydrophilic Poly(ethylene oxide) Block

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Abstract

The influence of synthetic water-soluble uncharged block copolymers on the multiplication of cells in a culture is studied. Their hydrophilic blocks are represented by linear poly(ethylene glycol) or branched polyglycerol, and hydrophobic blocks, by poly(propylene oxide) or polydimethylsiloxane. MCF-7/Adr cells are incubated with the copolymers in a serum-free culture medium for one hour, and their number after three days of cultivation without a copolymer is determined. The number of cells increases only under the action of polymers containing a poly(ethylene glycol) block, i.e., the longer this block, the lower the concentration of the polymer sufficient for the increase. The replacement of poly(ethylene glycol) by a hydrophilic block with a different structure, branched polyglycerol, fully cancels such an effect, thus indicating the defining role of poly(ethylene glycol) in the ability of block copolymers to maintain the multiplication of cells.

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Authors and Affiliations

  1. Department of Chemistry, Moscow State University, 119899, Moscow, Russia

    O. E. Musatova, E. S. Garina & I. D. Grozdova

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  1. O. E. Musatova
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  2. E. S. Garina
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  3. I. D. Grozdova
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Correspondence to I. D. Grozdova.

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Translated by E. Boltukhina

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Musatova, O.E., Garina, E.S. & Grozdova, I.D. The Ability of Pluronics to Increase the Survival Rate of Cells Determined by a Hydrophilic Poly(ethylene oxide) Block. Polym. Sci. Ser. A 62, 70–77 (2020). https://doi.org/10.1134/S0965545X19050134

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  • DOI: https://doi.org/10.1134/S0965545X19050134

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